Abstract
It is well-known that free radical reactions play an important role in biosystem functioning. Activation of such processes can result in creation and development of various pathological states of an organism. Among a multitude of homolytic reactions, the only cell damage process studied in detail is lipid peroxidation (LPO). It has been established that targets in these reactions are residues of unsaturated fatty acids, the constituents of lipids, and the process itself can be described by the following general scheme:
The membrane lipids most susceptible to LPO are those possesing carbon-tocarbon double bonds. The LPO products cause changes in the membrane structure, usually making the membrane more rigid. Many of these products are highly reactive: they interact with proteins and nucleic acids, and thus are mutagenic. Some of these reactions play a key role in the development of radiation injury, cancer, ishemia and degenerative deseases [1,2]. Because of this, the LPO reactions have been studied sufficiently well. On the other hand, little information is available on other free radical lipid modification reactions.
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Shadyro, O.I. (1997). Radiation-Induced Free Radical Fragmentation of Cell Membrane Components and the Respective Model Compounds. In: Minisci, F. (eds) Free Radicals in Biology and Environment. NATO ASI Series, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1607-9_24
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DOI: https://doi.org/10.1007/978-94-017-1607-9_24
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