Abstract
The primary reaction under UV irradiation of human blood and skin is photo-induced lipid peroxidation (PLPO). One early effect of PLPO is modification of Ca-ATPase, which is converted from a pump into the channel, through which Ca2+ -ions penetrate into the cytoplasm, so activating cells. The subsequent events give rise to final photobiological response, such as erythema.
There are three mechanisms of low-energy laser action on human cells and tissues: (1) photodynamic action (photo-induced lipid peroxidation), (2) photoreactivation of Cu-Zn-superoxide dismutase, and (3) photolysis of NO-hemoglobin complexes. The reaction 1 brings about the priming of blood phagocytes, which may be responsible for antibacterial and vasodilatation effects of blood irradiation with He-Ne laser radiation. Reactions 2 and 3 may be responsible for NO protection from binding by superoxide radical or hemin compounds; the final result will be vessel wall relaxation.
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Vladimirov, Y.A. (1997). Free-Radical Mechanisms of Action of UV and Laser Radiation on Human Blood Cells and Tissues. In: Minisci, F. (eds) Free Radicals in Biology and Environment. NATO ASI Series, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1607-9_22
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DOI: https://doi.org/10.1007/978-94-017-1607-9_22
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