Abstract
Many antibiotics of the bleomycin and enediyne family induce DNA strand cleavage by abstracting a hydrogen atom from the 4’-position of the deoxyribose unit thus forming 4’-DNA radicals as intermediates. Recently, we have synthesized the modified nucleosides 1 and 2 which are precursors of 4’-nucleoside radicals.1
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References
Giese, B., Erdmann, P., SchAfer, T. and Schwitter, U. (1994) Synthesis of a 4’selenated 2-deoxyadenosine derivative: A novel precursor for the preparation of modified oligonucleotides, Synthesis 1310–1312;
Giese, B., Imwinkelried, P. and Petretta, M. (1994) Synthesis of a modified thymidine and preparation of precursors of oligonucleotide radicals, Synlett 1003–1004.
Giese, B., Dussy, A., Elie, C., Erdmann, P. and Schwitter, U. (1994) Synthesis and selective radical cleavage of C-4’-modified oligonucleotides, Angew. Chem. Int. Ed. Engl. 33, 1861–1863.
Giese, B. Beyrich-Graf, X., Erdmann, P., Giraud, L., Imwinkelried, P., Müller, S. N. and Schwitter, U. (1995) Cleavage of single-stranded 4’-oligonucleotide radicals in the presence of 02, J. Am. Chem. Soc. 117, 6146–6147;
Giese, B. Beyrich-Graf, X., Erdmann, P., Petretta, M. and Schwitter, U. (1995) The chemistry of single-stranded 4’-DNA radicals, Chem. & Biol. 2, 367–375.
Hess, M. T., Schwitter, U., Petretta, M., Giese, B. and Naegeli, H. (1996) Site-specific substrates for human excision repair: Comparison between deoxyribose and base adducts, Chem. & Biol. 3, 121–128.
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© 1997 Springer Science+Business Media Dordrecht
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Giese, B., Marx, A., Schwitter, U. (1997). Chemistry and Biochemistry of DNA Radicals. In: Minisci, F. (eds) Free Radicals in Biology and Environment. NATO ASI Series, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1607-9_20
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DOI: https://doi.org/10.1007/978-94-017-1607-9_20
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-4831-8
Online ISBN: 978-94-017-1607-9
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