Abstract
The human Y chromosome is one of the smallest human chromosomes with an estimated average size of 50–60 Mb (Morton, 1991; Tilford et al., 2001). Size variability is mostly caused by polymorphism in the length of the constitutive heterochromatin located in the long arm in Yq12. It is characterized by its bipartite structure and function. It is flanked by pseudoautosomal regions at the distal short arm (PAR1) and distal long arm (PAR2), the sequences of which are shared by, and undergo meiotic recombination with the X chromosome. Between these two PARs there is the non-recombining region of the human Y chromosome (NRY), which comprises about 95% of the chromosome. This NRY does not undergo sexual recombination and is thus male-specific.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Conrad C, Hierl T, Gläser B, Taylor K, Zeitler S, Chandley A, Schempp W (1996). High-resolution fluorescence in situ hybridization of RBM- and TSPY-related cosmids on released Y chromatin in humans and pygmy chimpanzees. Chromosome Res 5: 23–30.
Fidlerovà H, Senger G, Kost M, Sanseau P, Sheer D (1994). Two simple procedures for releasing chromatin from routinely fixed cells for fluorescence in situ hybridization. Cytogenet Cell Genet 65: 203–205.
Foote S, Vollrath D, Hilton A, Page DC (1992). The human Y chromosome: overlapping DNA clones spanning the euchromatic region. Science 258: 60–66.
Gläser B, Hierl T, Taylor K, Schiebel K, Zeitler S, Papadopoullos K, Rappold G, Schempp W (1997a). High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin. Chromosome Res 5: 23–30.
Gläser B, Grützner F, Taylor K, Schiebel K, Meroni G, Tsioupra K, Pasantes J, Rietschel W, Toder R, Willmann U, Zeitler S, Yen P, Ballabio A, Rappold G, Schempp W (1997b). Comparative mapping of human Xp22 genes in hominoids—evolutionary linear instability of their Y homologues. Chromosome Res 5: 167–176.
Gläser B, Grützner F, Willman U, Stanyon R, Arnold N, Taylor K, Rietschel W, Zeitler S, Toder R, Schempp W (1998a). Simian Y chromosomes: species-specific rearrangements of DAZ, RBM, and TSPY versus contiguity of PAR and SRY. Mamm Genome 9: 226–231.
Gläser B, Yen P, Schempp W (1998b). Fibre-fluorescence in situ hybridization unravels apparently seven DAZ genes or pseudogenes clustered within a Y-chromosome region frequently deleted in azoospermic males. Chromosome Res 6: 481–486.
Gläser B, Myrtek D, Rumpler Y, Schiebel K, Hauwy M, Rappold GA, Schempp W (1999). Transposition of SRY into the ancestral pseudoautosomal region creates a new pseudoautosomal boundary in a progenitor of simian primates. Hum Mol Genet 8: 2, 071–2, 078.
Heng HHQ, Squire J, Tsui L-C (1992). High-resolution mapping of mammalian genes by in situ hybridization to free chromatin. Proc Natl Acad Sci USA 89: 9, 509–9, 513.
Jones MH, Khwaja OSA, Briggs H, et al. (1994). A set of ninety-seven overlapping yeast artificial chromosome clones spanning the human Y chromosome euchromatin. Genomics 24: 266–275.
Lahn BT, Page DC (1999). Four evolutionary strata on the human X chromosome. Science 286: 964–967.
Morton NE (1991). Parameters of the human genome. Proc Natl Acad Sci USA 88: 7, 474–7, 476.
Neil DL, Villsante A, Fisher RB, Vetrie D, Cox B, Tyler-Smith C (1990). Structural instability of human tandemly repeated DNA sequences cloned in yeast artificial chromosome vectors. Nucleic Acids Res 18: 1, 421–1, 428.
Ohno S (1967). Sex Chromosomes and Sex Linked Genes. Berlin: Springer.
Parra I, Windle B (1993). High resolution visual mapping of stretched DNA by fluorescent hybridization. Nat Genet 5: 17–21.
Reijo R, Lee T-Y, Salo P, Alagappan R, Brown LG, Rosenberg M, Rozen S, Jaffe T, Straus D, Hovatta O, de la Chapelle A, Silber S, Page DC (1995). Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat Genet 10: 383–392.
Röttger S, Pasantes JJ, Baldermann C, Reichl E, Yen PH, Hansmann I, Schempp W (2000). Familial mosaicism of del(Y) and inv del(Y). Cytogenet Cell Genet 91: 208–211.
Saxena R, de Vries JWA, Repping S, Alagappan RK, Skaletzky H, Brown LG, Ma P, Chen E, Hoovers JMN, Page DC (2000). Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. Genomics 67: 256–267.
Senger G, Jones T, Fidlerovà H (1994). Released chromatin: linearized DNA for high resolution fluorescence in situ hybridization. Hum Mol Genet 3: 1, 275–1, 280.
Taylor K, Hornigold N, Conway D, et al. (1996). Mapping the human Y chromosome by fingerprinting cosmid clones. Genome Res 6: 235–248.
Tilford CA, Kuroda-Kawaguchi T, Skaletzky H, Rozen S, Brown LG, Rosenberg M, McPherson JD, Wylie K, Sekhon M, Kucaba TA, Waterston RH, Page DC (2001). A physical map of the human Y chromosome. Nature 409: 943–945.
Wimmer R, Kirsch S, Rappold GA, Schempp W (2001). Direct evidence for a Homo-Pan clade. Chromosome Res (in press).
Yen P (1998). A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males. Genomics 54: 5–12.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Schempp, W. (2004). Evolution of the Y Chromosome in Primates. In: Schmid, M., Nanda, I. (eds) Chromosomes Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1033-6_4
Download citation
DOI: https://doi.org/10.1007/978-94-017-1033-6_4
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-5855-3
Online ISBN: 978-94-017-1033-6
eBook Packages: Springer Book Archive