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G Proteins and Map Kinase Cascades in the Pheromone Response of Fungi

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Cell Signalling in Prokaryotes and Lower Metazoa

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Summary

Development in fungal systems occurs in response to environmental cues and external stimuli. Heterotrimeric G protein coupled receptors (GPCRs) provide these systems with the ability to receive and transmit external signals into the cell. Once the signal has been internalized, mitogen activated protein kinase (MAPK) and/or cAMP-dependent protein kinase (PKA) cascades amplify and integrate various stimuli. Studies of heterotrimeric G proteins in yeast and filamentous fungi reveal remarkable evolutionary conservation in the signal transduction pathways of lower eukaryotic and mammalian cells. Because of the ease of genetic and biochemical manipulation, fungi have proven to be an invaluable system for dissecting the complex regulatory networks involved in higher eukaryotic signalling. In this chapter, we will examine cell-cell communication in fungi by addressing the pheromone response signal transduction pathway. The similarities and differences observed between the Saccharomyces cerevisiae and Schizosaccharomyces pombe yeast pheromone response pathways will be used as a paradigm for discussing sexual development in the filamentous species Cryptococcus neoformans, Magnaporthe grisea,Neurospora crassa, and Ustilago maydis.

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  1. Department of Microbiology and Molecular Genetics, University of Texas-Houston Medical School, Houston, Texas, 77030, USA

    Ann Kays & Katherine A. Borkovich

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  1. Ann Kays
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  1. School of Biology and Biochemistry, The Queen’s University of Belfast, Belfast, Northern Ireland

    Ian Fairweather

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Kays, A., Borkovich, K.A. (2004). G Proteins and Map Kinase Cascades in the Pheromone Response of Fungi. In: Fairweather, I. (eds) Cell Signalling in Prokaryotes and Lower Metazoa. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0998-9_1

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  • DOI: https://doi.org/10.1007/978-94-017-0998-9_1

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