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Pharmaceutical gene medicines for non-viral gene therapy

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Biopharmaceuticals, an Industrial Perspective

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Abstract

Gene therapy entails the introduction of a selected gene into a specific somatic cell such that subsequent expression of the gene achieves a therapeutic goal. One of the technical challenges to developing successful gene therapy protocols remains the development of safe and effective gene delivery systems. This chapter focuses upon the many non-viral approaches to achieving target-specific gene delivery. After discussing plasmid-based gene medicines and their manufacture, lipid-, polymer- and polypeptide-based gene delivery systems are presented in detail. A selected review of clinical trials undertaken using non-viral delivery systems is then presented.

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Author information

Authors and Affiliations

  1. Gene Medicine, Inc., 8301 New Trails Drive, The Woodlands, Texas, YSA

    A. Rolland, S. Sullivan & K. Petrak

Authors
  1. A. Rolland
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  2. S. Sullivan
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  3. K. Petrak
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Editor information

Editors and Affiliations

  1. University of Limerick, Limerick, Ireland

    Gary Walsh

  2. Limerick Institute of Technology, Limerick, Ireland

    Brendan Murphy

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© 1999 Springer Science+Business Media Dordrecht

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Rolland, A., Sullivan, S., Petrak, K. (1999). Pharmaceutical gene medicines for non-viral gene therapy. In: Walsh, G., Murphy, B. (eds) Biopharmaceuticals, an Industrial Perspective. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0926-2_20

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  • DOI: https://doi.org/10.1007/978-94-017-0926-2_20

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5237-7

  • Online ISBN: 978-94-017-0926-2

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