Skip to main content

Adenocarcinoma in Barrett’s Esophagus: Signs, Symptoms and Endoscopic Appearance

  • Chapter
  • 196 Accesses

Abstract

The incidence of adenocarcinoma of the esophagus has increased at a rate greater than that for any other cancer over the last 20 years. Whereas early adenocarcinoma is clinically silent but imminently curable, advanced cancer classically presents with progressive dysphagia to solids and liquids and is generally incurable. This chapter will review the clinical and endoscopic findings of esophageal adenocarcinoma.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tytgat G. Does endoscopie surveillance in esophageal columnar metaplasia (Barrett’s esophagus) have any real value? Endoscopy 1995; 27: 19–26.

    Article  PubMed  CAS  Google Scholar 

  2. Sabik JF, Rice TW, Goldblum JR, Koka A, Kirby TJ, Medendorp SV, Adelstein DJ. Superficial esophageal carcinoma. Ann Thorac Surg 1995; 60: 896–902.

    Article  PubMed  CAS  Google Scholar 

  3. Falk GW. Unresolved issues in Barrett’s esophagus in the new millennium. Dig Dis 2000; 18: 27–42.

    Article  PubMed  CAS  Google Scholar 

  4. Triadafilopoulos G. Nonobstructive dysphagia in reflux esophagitis. Am J Gastroenterol 1989; 84: 614–8.

    PubMed  CAS  Google Scholar 

  5. Skinner DB, Walther BC, Riddell RH, Schmidt H, Iascone C, DeMeester TR. Barrett’s esophagus. Comparison of benign and malignant cases. Ann Surg 1983; 198: 554–66.

    Article  PubMed  CAS  Google Scholar 

  6. Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999; 340: 825–31.

    Article  PubMed  CAS  Google Scholar 

  7. Locke GR, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997; 112: 1448–56.

    Article  PubMed  Google Scholar 

  8. Johnson DA, Winters C, Spurting TJ, Chobanian SJ, Cattau EL. Esophageal acid sensitivity in Barrett’s esophagus. J Clin Gastroenterol 1987; 91: 23–7.

    Article  Google Scholar 

  9. Grade A, Pulliam G, Johnson C, Garewal H, Sampliner RE, Fass R. Reduced chemoreceptor sensitivity in patients with Barrett’s esophagus may be related to age and not to the presence of Barrett’s epithelium. Am J Gastroenterol 1997; 92: 2040–3.

    PubMed  CAS  Google Scholar 

  10. Bytzer P, Christensen PB, Damkier P, Vinding K, Seersholm N. Adenocarcinoma of the esophagus and Barrett’s esophagus: a population-based study. Am J Gastroenterol 1999; 94: 86–91.

    Article  PubMed  CAS  Google Scholar 

  11. Menke-Pluymers MB, Schoute NW, Mulder AH, Hop WC, Van Blankenstein M, Tilanus HW. Outcome of surgical treatment of adenocarcinoma in Barrett’s esophagus. Gut 1992; 33: 1454–8.

    Article  PubMed  CAS  Google Scholar 

  12. Boyce HW. Dysphagia. Clinical Update. American Society for Gastrointestinal Endoscopy 1993; 1: 1–4.

    Google Scholar 

  13. Witt TR, Bains MS, Zaman MB, Martini N. Adenocarcinoma in Barrett’s esophagus. J Thorac Cardiovasc Surg 1983; 85: 337–45.

    PubMed  CAS  Google Scholar 

  14. Sanfey H, Hamilton SR, Smith RL, Cameron JL. Carcinoma arising in Barrett’s esophagus. Surg Gynecol Obstet 1985; 161: 570–4.

    PubMed  CAS  Google Scholar 

  15. Williamson WA, Ellis FH, Gibb SP, Shahian DM, Aretz HT, Heatley GJ, Watkins E. Barrett’s esophagus. Prevalence and incidence of adenocarcinoma. Arch Intern Med 1991; 151: 2212–6.

    Article  PubMed  CAS  Google Scholar 

  16. Duhaylongsod FG, Wolfe WG. Barrett’s esophagus and adenocarcinoma of the esophagus and gastroesophageal junction. J Thorac Cardiovasc Surg 1991; 102: 36–42.

    PubMed  CAS  Google Scholar 

  17. Heitmiller RF, Redmond M, Hamilton SR. Barrett’s esophagus with high-grade dysplasia. An indication for prophylactic esophagectomy. Ann Surg 1996; 224: 66–71.

    Article  PubMed  CAS  Google Scholar 

  18. Lerut T, Coosemans W, Van Raemdonck D, Dillemans B, De Leyn P, Mamette JM, Geboes K. Surgical treatment of Barrett’s carcinoma. Correlations between morphologic findings and prognosis. J Thorac Cardiovasc Surg 1994; 107: 1059–66.

    PubMed  CAS  Google Scholar 

  19. Spechler SJ. AGA technical review on treatment of patients with dysphagia caused by benign disorders of the distal esophagus. Gastroenterology 1999; 117: 23354.

    Google Scholar 

  20. Cameron M, Lomboy CT. Barrett’s esophagus: age, prevalence, and extent of columnar epithelium. Gastroenterology 1992; 103: 1241–5.

    PubMed  CAS  Google Scholar 

  21. Hamilton SR, Smith RR, Cameron 1L. Prevalence and characteristics of Barrett’s esophagus in patients with adenocarcinoma of the esophagus or esophagogastric junction. Hum Pathol 1988; 19: 942–8.

    Article  PubMed  CAS  Google Scholar 

  22. Nishimaki T, Holscher AH, Schuler M, Bollschweiler E, Becker K, Siewert JR. Histopathologic characteristics of early adenocarcinoma in Barrett’s esophagus. Cancer 1991; 68: 1731–6.

    Article  PubMed  CAS  Google Scholar 

  23. Falk GW, Rice TW, Goldblum JR, Richter JE. Jumbo biopsy forceps protocol still misses unsuspected cancer in Barrett’s esophagus with high-grade dysplasia. Gastrointest Endosc 1999; 49: 170–6.

    Article  PubMed  CAS  Google Scholar 

  24. Levine DS, Haggitt RC, Blount PL, Rabinovitch PS, Rusch VW, Reid BJ. An endoscopie biopsy protocol can differentiate high-grade dysplasia from early adenocarcinoma in Barrett’s esophagus. Gastroenterology 1993; 105: 40–50.

    PubMed  CAS  Google Scholar 

  25. Cameron AJ, Carpenter HA. Barrett’s esophagus, high-grade dysplasia and early adenocarcinoma: a pathological study. Am J Gastroenterol 1997; 92: 586–91.

    PubMed  CAS  Google Scholar 

  26. Pera M, Trastek VF, Carpenter HA, Allen MS, Deschamps C, Pairolero PC. Barrett’s esophagus with high-grade dysplasia: an indication for esophagectomy? Ann Thorac Surg 1992; 54: 199–204.

    Article  PubMed  CAS  Google Scholar 

  27. Sampliner RE. Practice guidelines on the diagnosis, surveillance, and therapy of Barrett’s esophagus, Am J Gastroenterol 1998; 93: 1028–32.

    Article  PubMed  CAS  Google Scholar 

  28. Panjehpour M, Overholt BF, Vo-Dinh T, Haggitt RC, Edwards DH, Buckley FP. Endoscopie fluorescence detection of high-grade dysplasia in Barrett’s esophagus. Gastroenterology 1996; 1 11: 93–101.

    Article  Google Scholar 

  29. Von Holstein CS, Nilsson AM, Engels SA, Willen R, Walther B, Svanberg K. Detection of adenocarcinoma in Barrett’s oesophagus by means of laser induced fluorescence. Gut 1996; 39: 711–6.

    Article  Google Scholar 

  30. Haringsma J, Prawirodirdjo W, Tytgat GN. Accuracy of fluorescence imaging of dysplasia in Barrett’s esophagus. Gastroenterology 1999; 116: A418 (Abstract).

    Google Scholar 

  31. Falk GW, Ours TM, Richter JE. Practice patterns for surveillance of Barrett’s esophagus in the USA. Gastrointest Endosc 2000; 52: 197–203.

    Article  PubMed  CAS  Google Scholar 

  32. Lightdale CJ. Esophageal cancer. Am J Gastroenterol 1999; 94: 20–9.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Falk, G.W. (2001). Adenocarcinoma in Barrett’s Esophagus: Signs, Symptoms and Endoscopic Appearance. In: Tilanus, H.W., Attwood, S.E.A. (eds) Barrett’s Esophagus. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0829-6_22

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-0829-6_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5860-7

  • Online ISBN: 978-94-017-0829-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics