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Annual Reports in Combinatorial Chemistry and Molecular Diversity pp 41–52Cite as

Accessing carbohydrate-based combinatorial libraries through solid phase and solution phase approaches

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Part of the book series: Annual Reports in Combinatorial Chemistry and Molecular Diversity ((ARCC,volume 2))

Abstract

The pursuit of chemical diversity for the purpose of drug discovery has focused primarily on the generation of peptide and heterocyclic small molecule combinatorial libraries [1–3]. With genomics initiatives beginning to dramatically increase the number of interesting biomolecular targets, a great need has arisen for expanding the universe of molecular structures available for screening. Although carbohydrates play fundamental roles in many biological processes [4,5] and are found as structural units in many drugs [6,7], they are poorly represented in the historical structurally biased chemical sample collections being used by most drug discovery organizations in their screening programs. However, it is because of their biological importance and unique chemical characteristics that carbohydrates are valuable in generating leads through drug discovery screening efforts.

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Authors and Affiliations

  1. Intercardia Inc., 8 Cedar Brook Drive, Cranbury, NJ, 08512, USA

    Michael J. Sofia

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  1. Michael J. Sofia
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Editors and Affiliations

  1. Mitokor, 92121, San Diego, CA, USA

    W. H. Moos

  2. Millennium Pharmaceuticals, 02139, Cambridge, MA, USA

    M. R. Pavia

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© 1999 Springer Science+Business Media Dordrecht

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Sofia, M.J. (1999). Accessing carbohydrate-based combinatorial libraries through solid phase and solution phase approaches. In: Moos, W.H., Pavia, M.R. (eds) Annual Reports in Combinatorial Chemistry and Molecular Diversity. Annual Reports in Combinatorial Chemistry and Molecular Diversity, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0735-0_6

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  • DOI: https://doi.org/10.1007/978-94-017-0735-0_6

  • Publisher Name: Springer, Dordrecht

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  • Online ISBN: 978-94-017-0735-0

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