Abstract
Cancer chemoprevention with food phytochemicals is currently regarded as one of the noticeable scientific fields. We have screened more than 400 extracts from vegetables and fruits for the anti-tumor promoting activity using a cell culture system. The Zingiberaceae plants in Southeast Asian countries were indicated to be notable sources to identify effective cancer chemopreventive agents. In addition, lā-acetoxychavicol acetate (ACA), a phenyl propanoid, isolated from the rhizomes of Languas galanga, was found to be a potent chemopreventive agent which markedly suppresses phorbol ester-induced superoxide (O ā2 ) generation and endotoxin-induced nitric oxide (NO) production.
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Ā© 2002 Springer Science+Business Media Dordrecht
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Murakami, A., Nakamura, Y., Koshimizu, K., Ohigashi, H. (2002). Search for Chemopreventive Agents on the Basis of the Involvement of Oxidative Stress and Inflammation in Carcinogenesis. In: Shirahata, S., Teruya, K., Katakura, Y. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0728-2_10
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DOI: https://doi.org/10.1007/978-94-017-0728-2_10
Publisher Name: Springer, Dordrecht
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