Abstract
Recombinant adenovirus (Ad) vectors have been extensively used to deliver foreign genes to a variety of cell types in vitro and in vivo. They can be easily grown to high titer, and can transfer genes in both dividing and non-dividing cells. However, the construction of Ad vectors is a complex and time-consuming process. In this paper, we describe a simple system for the construction of not only a conventional Ad vector, but also a fiber mutant Ad vector to modulate the vector tropism.
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© 2002 Springer Science+Business Media Dordrecht
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Mizuguchi, H., Hayakawa, T. (2002). Improvement of Adenovirus Vectors for Gene Transfer. In: Shirahata, S., Teruya, K., Katakura, Y. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0728-2_1
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DOI: https://doi.org/10.1007/978-94-017-0728-2_1
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-5934-5
Online ISBN: 978-94-017-0728-2
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