Modulation of Leukocyte Function by Food Factors

Abstract

Tumor necrosis factor-α (TNF-α ) is a pleiotropic cytokine, originally discovered by its antitumor activity, and is believed to play a role in many immunologic and inflammatory reactions. However, its overproduction might cause immunological and inflammatory diseases; for example, prolonged exposure to TNF-α might cause cachexia involving waste. In a bacterial infection, the overproduction of TNF may cause septic shock leading to acute organ failure and death. TNF-α is also a critical mediator in skin diseases such as the contact hypersensitivity reaction. The inhibition of TNF-α overproduction is therefore essential for therapy to cure an inflammatory disease including carcinogenesis.