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Recombinant expression of human collagens

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Animal Cell Technology: Basic & Applied Aspects

Part of the book series: Animal Cell Technology: Basic & Applied Aspects ((ANICELLTECH,volume 13))

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Abstract

The collagens are a family of closely related but distinct extracellular matrix proteins that play a dominant role in maintaining the structural integrity of various tissues and organs (1). Type I collagen is the most abundant member of the collagen family and it is found in most connective tissues. It is currently used as a biomaterial in numerous medical applications and as a delivery system for various drugs. In addition, all gelatins widely used in pharmaceutical, food and beverage industries are prepared from collagens. The collagens used in all these applications have been isolated from animal tissues and are liable to cause allergic reactions in some subjects and carry a risk of disease-causing contaminants. More than 20 proteins have now been defined as collagens (1). The various collagen types have different properties, and therefore some of the other collagens might be more suitable for certain applications than type I. However, it has been difficult or impossible to isolate sufficient quantities of the other collagens from animal tissues. An efficient large-scale recombinant system for the production of human collagens would thus have numerous applications in medicine.

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Author information

Authors and Affiliations

  1. Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, PO Box 5000, FIN-90014, Finland

    Johanna Myllyharju

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  1. Johanna Myllyharju
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Editors and Affiliations

  1. Department of Applied Biological Science, Tokyo Noko University, Tokyo, Japan

    Kazumi Yagasaki , Yutaka Miura , Makoto Hatori  & Yoshihiro Nomura , ,  & 

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© 2003 Springer Science+Business Media Dordrecht

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Myllyharju, J. (2003). Recombinant expression of human collagens. In: Yagasaki, K., Miura, Y., Hatori, M., Nomura, Y. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0726-8_1

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  • DOI: https://doi.org/10.1007/978-94-017-0726-8_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6557-5

  • Online ISBN: 978-94-017-0726-8

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