Abstract
The only animal species readily infectable with HIV-1 is the chimpanzee. However, following infection with most HIV-1 isolates, chimpanzees do not develop disease [28]. Infection with some HIV-1 isolates results in seroconversion, but barely detectable plasma viral RNA. In these infected animals, virus isolations from peripheral blood are achievable only for a few weeks following HIV-1 inoculation [29]. Infection with other HIV-1 isolates results in a more intense viraemia with readily measurable viral RNA in the plasma and persistantly isolatable virus from the peripheral blood. However, the extent of viral replication in vivo with any of these usual HIV-1 isolates appears to decline over the first months following infection, resulting in an infectious process with a low level of viral replication and no disease pathogenesis.
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Letvin, N.L. (2000). B — Non-Human Primate Models for HIV-1 Infection. In: Schuitemaker, H., Miedema, F. (eds) AIDS Pathogenesis. Immunology and Medicine Series, vol 28. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0685-8_17
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DOI: https://doi.org/10.1007/978-94-017-0685-8_17
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