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AIDS Pathogenesis pp 273–278Cite as

A — The SCID-hu Mouse: An in-vivo Model for HIV-1 Infection in Humans

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Part of the book series: Immunology and Medicine Series ((IMME,volume 28))

Abstract

The decline of CD4+ T-cell number in the peripheral circulation has been considered an indicative barometer of HIV-1 disease progression. A variety of possible mechanisms for the loss of CD4+ T cells have been proposed, yet the main mechanism for immuno-pathogenesis remained unknown.

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Author information

Authors and Affiliations

  1. HIV Gene Therapy, SyStemix, Inc., Palo Alto, USA

    Hideto Kaneshima M.D. Ph.D.

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  1. Hideto Kaneshima M.D. Ph.D.
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Editors and Affiliations

  1. CLB and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands

    Hanneke Schuitemaker  & Frank Miedema  & 

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© 2000 Springer Science+Business Media Dordrecht

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Kaneshima, H. (2000). A — The SCID-hu Mouse: An in-vivo Model for HIV-1 Infection in Humans. In: Schuitemaker, H., Miedema, F. (eds) AIDS Pathogenesis. Immunology and Medicine Series, vol 28. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0685-8_16

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  • DOI: https://doi.org/10.1007/978-94-017-0685-8_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5407-4

  • Online ISBN: 978-94-017-0685-8

  • eBook Packages: Springer Book Archive

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