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HIV Viral Load

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AIDS Pathogenesis

Part of the book series: Immunology and Medicine Series ((IMME,volume 28))

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Abstract

Identification and weighting of factors that correlate with and possibly contribute to the outcome of infection with human immunodeficiency virus (HIV) is important for our understanding of the pathogenesis and natural history of HIV infection and in designing strategies for the treatment of infection. HIV infection runs a variable course in the population of infected individuals. Some develop AIDS within a few years post-infection; others do not develop AIDS in a decade.

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References

  1. De Wolf, F., Goudsmit, J., Paul, D.A.Risk of AIDS-related complex and AIDS in homosexual men with persistent HIV antigenaemia, Brit. Med. J 295 (1987), 569–572.

    Google Scholar 

  2. De Wolf, F., Lange, J.M.A., Houweling, J.T.M.Numbers of CD4’ cells and the levels of core antigens of and antibodies to the human immunodeficiency virus as predictors of AIDS among seropositive homosexual men, J. Infect. Dis 158 (1988), 615–622.

    Google Scholar 

  3. Moss, A.R., Bacchetti, P., Osmond, D.Seropositivity for HIV and the development of AIDS or AIDS-related conditions: three year follow up of the San Francisca General Hospital cohort, Brit. Med. J 296 (1988), 745–750.

    Article  CAS  Google Scholar 

  4. Koot, M., Keet, I.P.M Vos, A.H.V.Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4’ cell depletion and progression to AIDS, Ann. Intern. Med 118 (1993), 681–688.

    Google Scholar 

  5. Schuitemaker, H., Koot, M., Kootstra, N.A.Biological phenotype of human immuno- deficiency virus type-1 clones at different stages of infection: progression to disease is associated with a shift from monocytotropic to T-cell-tropic virus populations, J. Virol 66 (1992), 1354–1360.

    Google Scholar 

  6. Miedema, F., Petit, C.A.J., Terpstra, F.G.Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men, J. Clin. Invest 82 (1988), 1908–1914.

    Article  PubMed  CAS  Google Scholar 

  7. Shearer, G.M., Bernstein, D.C., Tung, K.S.K.A model for the selective loss of major histocompatibility complex self-restricted T-cell immune responses during the development of acquired immune deficiency syndrome (AIDS), J. Immunol 137 (1986), 2514–2521.

    Google Scholar 

  8. Giorgi, J.V., Fahey, J.L., Smith, D.C.Early effects of HIV on CD4’ lymphocytes in vivo, J. Immunol 138 (1987), 3725–3730.

    Google Scholar 

  9. Hofmann, B., Orskov Lindhardt, B., Gerstoft, J. et al: Lymphocyte transformation response to pokeweed mitogen as a marker for development of AIDS and AIDS-related symptoms in homosexual men with HIV antibodies, Brit. Med. 1 295 (1987), 293–296.

    CAS  Google Scholar 

  10. Terpstra, F.G., Al, B.J.M., Roos, M.Th.L.Longitudinal study of leukocyte functions in homosexual men seroconverted for HIV: rapid and persistent loss of B-cell function after HIV infection, Eur. J Immunol 19 (1989), 667–673.

    Google Scholar 

  11. Schellekens, P.Th.A., Roos, M.Th.L., De Wolf, F.Low level responsiveness to activation via CD3/TCR is a prognostic marker for AIDS in HIV-1-infected men, J. Clin. Immunol 10 (1990), 121–127.

    Google Scholar 

  12. Roos, M.Th.L., Miedema, F., Koot, M.T-cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus-infected asymptomatic subjects, J. Infect. Dis 171 (1995), 531–536.

    Google Scholar 

  13. Schellekens, P.Th.A., Tersmette, M., Roos, M.Th.L.Biphasic rate of CD4’ cell count decline during progression to AIDS correlates with HIV-1 phenotype, AIDS 6 (1992), 665–669.

    Google Scholar 

  14. Hofmann, B., Wang, Y., Cumberland, W.G.Serum beta2-microglobulin level increases in HIV infection: relation to seroconversion, CD4 T-cell fall and prognosis, AIDS 4 (1990), 207214.

    Google Scholar 

  15. Fahey, J.L., Taylor, J.M.G., Detels, R.The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1, New Engl. J. Med 322 (1990), 166–172.

    Google Scholar 

  16. Polk, B.F., Fox, R., Brookmeyer, R.Predictors of the acquired immunodeficiency syn- drome developing in a cohort of seropositive homosexual men, New Engl. J. Med 316 (1987), 61–66.

    Google Scholar 

  17. Felsenstein, J.: Parsimony in systematics: biological and statistical issues, Ann. Rev. Syst 14 (1983), 313–333.

    Article  Google Scholar 

  18. Stein, D.S., Korvick, J.A. and Vermund, S.H.: CD4’ lymphocyte cell enumeration for prediction of clinical course of human immunodeficiency virus disease: a review, J. Infect. Dis 165 (1992), 352–356.

    Article  PubMed  CAS  Google Scholar 

  19. Ho, D.D., Neumann, A.U., Perelson, A.S.Rapid turnover of plasma virions and CD4’ lymphocytes in HIV-1 infection, Nature 373 (1995), 123–126.

    Google Scholar 

  20. Wei, X., Ghosh, S.K., Taylor, M.E.Viral dynamics in human immunodeficiency virus type-I infection, Nature 373 (1995), 117–122.

    Google Scholar 

  21. Jurriaans, S., Van Gemen, B., Weverling, G.J.The natural history of HIV-1 infection: virus load and virus phenotype independent determinants of clinical course?, Virology 204 (1994), 223–233.

    Google Scholar 

  22. Henrard, D.R., Phillips, J.F., Muenz, L.R.Natural history of HIV-1 cell-free viremia, JAMA 274 (1995), 554–558.

    Google Scholar 

  23. Hogervorst, E., Jurriaans, S., De Wolf, F.Predictors for non-and slow progression in human immunodeficiency virus (HIV) type-1 infection: low viral RNA copy numbers in serum and maintenance of high HIV-I p24-specific but not V3-specific antibody levels, J. Infect. Dis 171 (1995), 811–821.

    Google Scholar 

  24. Mellors, J.W., Kingsley, L.A., Rinaldo Jr., C.R.Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion, Ann. Intern. Med 122 (1995), 573–579.

    Google Scholar 

  25. Mellors, J.W., Rinaldo Jr., C.R., Gupta, P.Prognosis for HIV-1 infection predicted by the quantity of virus in plasma, Science 272 (1996), 1167–1170.

    Google Scholar 

  26. Katzenstein, D.A., Hammer, S.M., Hughes, M.D.The relation of virologie and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter, New Engl. J. Med 335 (1996), 1091–1098.

    Google Scholar 

  27. O’Brien, W.A., Hartigan, P.M., Martin, D.Changes in plasma HIV-1 RNA and CD4’ lymphocyte counts and the risk of progression to AIDS, New Engl. J. Med 334 (1996), 426–431.

    Google Scholar 

  28. Ho, D.D., Moudgil, T. and Alam, M.: Quantitation of human immunodeficiency virus type 1 in the blood of infected persons, New Engl. J. Med 321 (1989), 1621–1625.

    Article  PubMed  CAS  Google Scholar 

  29. Coombs, R.W., Collier, A.C., Allain, J.P.Plasma viremia in human immunodeficiency virus infection, New Engl. J. Med 321 (1989), 1626–1631.

    Google Scholar 

  30. Clark, S.J., Saag, M.S., Decker, W.D.High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection, New Engl. J. Med 324 (1991), 954–960.

    Google Scholar 

  31. Daar, E.S., Moudgil, T., Meyer, R.D.Transient high levels of viremia in patients with primary human immunodeficiency virus type-1 infection, New Engl. J. Med 324 (1991), 961965.

    Google Scholar 

  32. Piatak Jr., M., Saag, M.S., Yang, L.C.High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR, Science 259 (1993), 1749–1754.

    Google Scholar 

  33. Blaak, H., De Wolf, F., Van ‘t Wout, A.B.Temporal relationship between human immunodeficiency virus type-1 RNA levels in serum and cellular infectious load in peripheral blood, J. Infect. Dis 176 (1997), 1383–1387.

    Google Scholar 

  34. Huisman, J.G., Bruisten, S.M. and Cuypers, H.T.M.: Kwantitatieve bepaling van HIV-1RNA/DNA, CLB Bull. March (1995), 4–6.

    Google Scholar 

  35. Volberding, P.A.: HIV quantification: clinical applications, Lancet 347 (1996), 71–73.

    Article  PubMed  CAS  Google Scholar 

  36. Weverling, G.J., Lange, J.M.A., De Jong, M.D.A comparison of serum HIV-1 RNA levels are measured by two quantitative assays in Zidovudine-treated asymptomatic individuals, Antiviral Treatment 1 (1996), 255–263.

    Google Scholar 

  37. De Wolf, F. and Goudsmit, J.: AIDS; nieuwe ontwikkelingen. III. Voorspellende waarde van de hoeveelheid HIV-RNA voor het beloop van de HIV infectie en het effect van de behandeling, Ned. Tijdschr. Geneeskd 141 (1997), 1043–1050.

    PubMed  Google Scholar 

  38. Cao, Y., Ho, D.D., Todd, J. et al: Clinical evaluation of branched DNA signal amplification for quantifying HIV type 1 in human plasma, AIDS Res. Human Retrovir 11 (1995), 353–361.

    Article  CAS  Google Scholar 

  39. Revets, H., Marissens, D., De Wit, S.Comparative evaluation of NASBA HIV-1 RNA QT, Amplicor-HIV monitor, and Quantiplex HIV RNA assay, three methods for quantification of human immunodeficiency virus type-1 RNA in plasma, J. Clin. Microbial 34 (1996), 1058–1064.

    Google Scholar 

  40. Coffin, J.M.: HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy, Science 267 (1995), 483–489.

    Article  PubMed  CAS  Google Scholar 

  41. Perelson, A.S., Neumann, A.U., Markowitz, M.HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time, Science 271 (1996), 1582–1586.

    Google Scholar 

  42. Chun, T.-W., Carruth, L.M., Finzi, D.Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection, Nature 387 (1997), 183–188.

    Google Scholar 

  43. Stevenson, M., Stanwick, T.L., Dempsey, M.P. and Lamonica, C.A.: HIV-1 replication is controlled at the level of T-cell activation and proviral integration, EMBO 1 9 (1990), 15511560.

    Google Scholar 

  44. Bukrinsky, M.I., Stanwick, T.L., Dempsey, M.P. and Stevenson, M.: Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection, Science 254 (1991), 423–427.

    Article  PubMed  CAS  Google Scholar 

  45. Stevenson, M.: Molecular mechanisms for the regulation of HIV replication, persistence and latency, AIDS 11 (suppl. A) (1997), S25–S33.

    Google Scholar 

  46. Van Gemen, B., Kievits, T., Schukkink, RQuantification of HIV-1 RNA in plasma using NASBA during HIV-1 primary infection, J. Virol. Methods 43 (1993), 177–188.

    Google Scholar 

  47. Koup, R.A., Safrit, J.T.,Cao, Y. et al, Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type-1 syndrome, J. Virol 68 (1994), 4650–4655.

    Google Scholar 

  48. Lange, J.M.A., Coutinho, R.A., Krone, W.J.A.Distinct IgG recognition patterns during progression of subclinical and clinical infection with lymphadenopathy-associated virus/human T-lymphotropic virus, Brit. Med. J 292 (1986), 228–230.

    Google Scholar 

  49. Goudsmit, J., De Wolf, F., Paul, D.A.Expression of human immunodeficiency virus antigen (HIV-Ag) in serum and cerebrospinal fluid during acute and chronic infection, Lancet ii (1986), 177–180.

    Google Scholar 

  50. Phillips, A.N.: Reduction of 111V concentration during acute infection: independence of a specific immune response, Science 271 (1996), 497–499.

    Article  PubMed  CAS  Google Scholar 

  51. De Wolf, F., Spijkerman, I., Schellekens, P.Th.A.AIDS prognosis based on HIV-1 RNA, CD4’ T-cell count and function: markers with reciprocal predictive value over time after seroconversion, AIDS 11 (1997), 1799–1806.

    Google Scholar 

  52. Spijkerman, I.J.B., Prins, M., Goudsmit, J. et al: Early and late HIV-1 RNA level and its association with T-cell reactivity and disease progression in long-term AIDS-free homosexual men, AIDS 11 (1997), 1383–1388.

    Article  PubMed  CAS  Google Scholar 

  53. Spijkerman, I., De Wolf, F., Langendam, M.Emergence of syncytium-inducing HIV-1 variants coincides with a transient increase in viral RNA level and is an independent predictor for progression to AIDS, J. Infect. Dis 178 (1998), 397–403.

    Google Scholar 

  54. Ho, D.D.: Time to hit HIV, early and hard, New Engl. J. Med 333 (1995), 450–451.

    Article  PubMed  CAS  Google Scholar 

  55. Loveday, C., Kaye, S., Tenant-Flowers, M.HIV-1 RNA serum load and resistant viral genotypes during early zidovudine therapy, Lancet 345 (1995), 820–824.

    Google Scholar 

  56. Eron, J.J., Benoit, S.L. and Jemsek, J.: Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4’ cells per cubic millimeter, New Engl. J. Med 333 (1995), 1662–1669.

    Article  PubMed  CAS  Google Scholar 

  57. Delta Coordinating Committee. Delta: A randomized double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals, Lancet 348 (1996), 283–291.

    Article  Google Scholar 

  58. Hammer, S.M., Katzenstein, D.A., Hughes, M.D.A trial comparing nucleoside mono-therapy with combination therapy in HIV-infected adults with CD4 counts from 200 to 500 per cubic millimeter. AIDS Clinical Trial Group Study 175 Study Team, New Engl. J. Med 335 (1996), 1081–1090.

    Google Scholar 

  59. Danner, S.A., Carr, A., Leonard, J.M.A short-term study of safety, pharmacokinetics, and efficacy of Ritonavir, an inhibitor of HIV-1 protease, New Engl. J. Med 333 (1995), 1528–1533.

    Google Scholar 

  60. Markowitz, M., Saag, M., Powderly, W.G.A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection, New Engl. J. Med 333 (1995), 1534–1539.

    Google Scholar 

  61. Kitchen, V.S., Skinner, C., Ariyoshi, K.Safety and activity of saquinavir in HIV infection, Lancet 345 (1995), 952–955.

    Google Scholar 

  62. Notermans, D.W., De Wolf, F., Foudraine, N.A.The effects of an antiretroviral combination with ritonavir, AZT and 3TC (Abstract), AIDS 10 (suppl. 2) (1996), S17.

    Google Scholar 

  63. Notermans, D.W., Jurriaans, S., De Wolf, F.Decrease of HIV-1 RNA levels in lymphoid tissue and peripheral blood during treatment with ritonavir, lamivudine and zidovudine, AIDS 12 (1998), 167–173.

    Google Scholar 

  64. Hammer, S.M., Squires, K.E., Hughes, M.D.A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less, New Engl. J. Med 337 (1997), 725–733.

    Article  PubMed  CAS  Google Scholar 

  65. Gulick, R.M., Mellors, J.W., Havlir, D.Treatment with indinavir, zidovudine and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy, New Engl. J. Med 337 (1997), 734–739.

    Google Scholar 

  66. Wong, J.K., Hezareh, M., Gunthard, H.F.Recovery of replication-competent HIV despite prolonged suppression of plasma viremia, Science 278 (1997), 1291–1295.

    Google Scholar 

  67. Finzi, D., Hermankova, M., Pierson, T.Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy, Science 278 (1997), 1295–1300.

    Google Scholar 

  68. Finzi, D. and Siliciano, R.F.: Viral dynamics in HIV-1 infection, Cell 93 (1998), 666–671.

    Article  Google Scholar 

  69. Pakker, N.G., Notermans, D.W., De Boer, R.J.Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV infection: a composite of redistribution and proliferation, Nature Med 4 (1998), 208–214.

    Google Scholar 

  70. Carpenter, C.J., Fischl, M.A., Hammer, S.A.Antiviral therapy for HIV infection in 1997: update recommendations of the International AIDS Society USA panel, JAMA 277 (1997), 19629.

    Google Scholar 

  71. Weverling, G.J., Lange, J.M.A., Jurriaans, S.Alternative multidrug regimen provides improved suppression of HIV-1 replication over triple therapy, AIDS 12 (1998), F117–F122.

    Google Scholar 

  72. De Wolf, F., De Jong, J., Hertogs, K.Virologische evaluatie van HIV-ge?nfecteerden behandeld met (combinaties van) anti-retrovirale middelen in het AMC 1996/1997: preliminaire waarnemingen, Ned. Tijdschr. Geneeskd 142 (1998), 573–578.

    Google Scholar 

  73. Cavert, W., Notermans, D.W., Staskus, K.Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection, Science 276 (1997), 960–964.

    Article  PubMed  CAS  Google Scholar 

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De Wolf, F., Spijkerman, I. (2000). HIV Viral Load. In: Schuitemaker, H., Miedema, F. (eds) AIDS Pathogenesis. Immunology and Medicine Series, vol 28. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0685-8_15

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  • DOI: https://doi.org/10.1007/978-94-017-0685-8_15

  • Publisher Name: Springer, Dordrecht

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