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B — Pathogenesis of Kaposi’s Sarcoma

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Book cover AIDS Pathogenesis

Part of the book series: Immunology and Medicine Series ((IMME,volume 28))

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Abstract

First described by the Austro-Hungarian dermatologist Moritz Kaposi in the last century [1], Kaposi’s sarcoma (KS) was for many years considered a rare, slowly progressive tumour of elderly males of some Mediterranean and Eastern European countries. In this “classical” form of KS, lesions are mainly confined to the skin and localised preferentially on the extremities. In the early 1950s, it was found that KS comprised up to 8% of malignancies in some sub-Saharan regions, in particular in parts of Central Africa, such as Zaire (for a compilation of epidemiological studies, see [2]). This “endemic” form of KS occasionally affects children [3]. KS is also more common among immunosuppressed organ transplant recipients, in particular if they come from countries where other forms of HIV-negative KS are more frequent [4,5]. However, in developed countries KS is now most commonly associated with HIV infection, and this variant, termed “epidemic KS” is characterised by widely distributed lesions, visceral as well as involving lymph nodes, and a rapidly progressive course.

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  1. Molecular Virology Group, Department of Medical Microbiology and Genitourinary Medicine, The University of Liverpool, Liverpool, England

    Thomas F. Schulz

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  1. Thomas F. Schulz
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  1. CLB and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands

    Hanneke Schuitemaker  & Frank Miedema  & 

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Schulz, T.F. (2000). B — Pathogenesis of Kaposi’s Sarcoma. In: Schuitemaker, H., Miedema, F. (eds) AIDS Pathogenesis. Immunology and Medicine Series, vol 28. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0685-8_11

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  • DOI: https://doi.org/10.1007/978-94-017-0685-8_11

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