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Aging of Cells in and Outside the Body pp 47–65Cite as

Aging of Endothelial Cells

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Part of the book series: Biology of Aging and its Modulation ((BIMO,volume 2))

Abstract

The endothelium acts as a barrier between blood and vascular smooth muscle cells by virtue of its position within the blood vessel wall. Therefore, the functional integrity of the endothelium monolayer, which is composed of endothelial cells (ECs), is essential to the prevention of vascular leakage and the formation of atherosclerotic lesions [1, 2], which are often found in the human vasculature of the elderly [3, 4]. Aging is an independent risk factor for atherosclerotic cardiovascular disease, leading to progressive impairment of organ function [3, 5, 6]. Changes in the vascular system, including structural and functional alterations of the arterial wall and an increase in blood pressure, frequently are observed during aging [7, 8]. As an important source of vasoactive substances, such as endothelin-1 (ET-1) and nitric oxide (NO), vascular ECs play a key role in the control of vascular tone. Because EC functions change during aging, EC senescence is an important pathogenetic factor in age-related vascular dysfunction [9].

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  1. Suzugamine Women’s College, 4-6-18 Inokuchi, Nishi-ku, Hiroshima, 733-8623, Japan

    Tsutomu Kumazaki

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  1. National Institute of Advanced Industrial, Science and Technology, Tsukuba Science City, Ibaraki, Japan

    Sunil C. Kaul  & Renu Wadhwa  & 

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Kumazaki, T. (2003). Aging of Endothelial Cells. In: Kaul, S.C., Wadhwa, R. (eds) Aging of Cells in and Outside the Body. Biology of Aging and its Modulation, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0669-8_4

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