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Aging at the Molecular Level pp 91–106Cite as

Mitochondria and Aging

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Part of the book series: Biology of Aging and Its Modulation ((BIMO,volume 1))

Abstract

Animal cells rely on oxidative phosphorylation to supply the chemical energy necessary for life. In this process electrons are transferred, via a series of membrane-bound enzymes (complexes I–IV) and mobile electron carriers (ubiquinone and cytochrome c) to molecular oxygen resulting in the formation of water [1]. The chemical energy involved in these electron transfers is stored as a transmembrane chemical gradient established by the translocation of protons across the membrane by complexes I,III and IV [2, 3]. This stored energy is then coupled to the formation of ATP by the controlled flow of protons down their chemical gradient within complex V, the ATP synthase.

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  1. Department of Neurology, The Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4EH, UK

    Martin Barron & Doug Turnbull

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  1. Martin Barron
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  1. Henry Wellcome Laboratory for Biogerontology, Newcastle General Hospital, University of Newcastle, Newcastle upon Tyne, UK

    Thomas von Zglinicki (Professor of Cellular Gerontology) (Professor of Cellular Gerontology)

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Barron, M., Turnbull, D. (2003). Mitochondria and Aging. In: von Zglinicki, T. (eds) Aging at the Molecular Level. Biology of Aging and Its Modulation, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0667-4_7

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  • DOI: https://doi.org/10.1007/978-94-017-0667-4_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6482-0

  • Online ISBN: 978-94-017-0667-4

  • eBook Packages: Springer Book Archive

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