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Oxidative Damage to Proteins

  • Chapter
Aging at the Molecular Level

Part of the book series: Biology of Aging and Its Modulation ((BIMO,volume 1))

Abstract

Protein oxidation in vivo is a natural consequence of aerobic life. Oxygen radicals and other reactive oxygen species that are generated as by-products of cellular metabolism or from environmental sources, cause modifications to amino acids of proteins. These generally result in loss of protein function and/or enzymatic activity. Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species (ROS). The appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to aging and life span.

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Authors and Affiliations

  1. Department of Anaesthesiology and Critical Care Medicine, CHARITÉ, University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany

    Nicolle Sitte

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  1. Nicolle Sitte
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Editors and Affiliations

  1. Henry Wellcome Laboratory for Biogerontology, Newcastle General Hospital, University of Newcastle, Newcastle upon Tyne, UK

    Thomas von Zglinicki (Professor of Cellular Gerontology) (Professor of Cellular Gerontology)

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Sitte, N. (2003). Oxidative Damage to Proteins. In: von Zglinicki, T. (eds) Aging at the Molecular Level. Biology of Aging and Its Modulation, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0667-4_3

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  • DOI: https://doi.org/10.1007/978-94-017-0667-4_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6482-0

  • Online ISBN: 978-94-017-0667-4

  • eBook Packages: Springer Book Archive

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