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The Proteasome in Aging

  • Chapter
Book cover Aging at the Molecular Level

Part of the book series: Biology of Aging and Its Modulation ((BIMO,volume 1))

Abstract

The proteasome is a major intracellular proteolytic system found in Archaebacteria and Eukaryotes, and degrades the majority of intracellular proteins including oxidized and ubiquitinated proteins [1, 2]. There is a large body of experimental evidence indicating that proteasome function is compromised during aging, a feature that may have important implications in the cellular aging process [3–6]. Indeed, aging is characterized by a progressive and irreversible decline of the different physiological functions of the organism during the last part of its life. Increased modification of macromolecules is a common mark of aging [7, 8] and proteins have been reported to be crucial targets for numerous post-translational damages (e.g., oxidation, glycation, glycoxidation, conjugation with lipid peroxidation products) which have been shown to directly impair their biological functions [9–11]. Interestingly, calorie restriction, the only intervention that slows down aging, modulates the age-related accumulation of altered proteins [12, 13]. The age-related build up of oxidatively modified protein raises the problem of the efficacy of the proteolytic systems in charge of eliminating these damaged proteins, in particular the efficacy of the proteasomal system. Following a detailed description of the proteasomal system, the impact of aging on proteasome structure and function is discussed in the light of studies aimed at characterizing the fate of proteasome during oxidative stress. The possible implication of age-related alterations on the proteasomal system in immune senescence and neurodegeneration is then presented.

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  1. Laboratoire de Biologie et Biochimie Cellulaire du Vieillissement (EA 3106 IFR 117/Biologie Systémique), Université Denis Diderot Paris 7, cc 7128, 2 place Jussieu, 75251, Paris Cedex 05, France

    Géraldine Carrard & Bertrand Friguet

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  1. Géraldine Carrard
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  2. Bertrand Friguet
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  1. Henry Wellcome Laboratory for Biogerontology, Newcastle General Hospital, University of Newcastle, Newcastle upon Tyne, UK

    Thomas von Zglinicki (Professor of Cellular Gerontology) (Professor of Cellular Gerontology)

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Carrard, G., Friguet, B. (2003). The Proteasome in Aging. In: von Zglinicki, T. (eds) Aging at the Molecular Level. Biology of Aging and Its Modulation, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0667-4_14

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  • DOI: https://doi.org/10.1007/978-94-017-0667-4_14

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