Summary
On-line measurement of oxygen uptake and carbon dioxide evolution in penicillin production by Penicillium chrysogenum mutant strain P2–4 in solid state fermentation were studied, with respect to the proportions of the nutrients, support and water. The data indicated their importance in achieving higher production of penicillin. The on-line measurement system for the gases allowed the detection of subtle changes in the metabolism of the culture and the correlation of respiratory changes with the start and end of penicillin production. The results established that the environmental conditions, which permit high penicillin production, are those, which result in lower respiration rates.
Resume
Le suivi en ligne de l’évolution de l’oxygène et du dioxyde de carbone, au cours de la production de penicilline par le mutant P2–4 de Penicillium chrysogenum cultivé en fermentation en milieu solide a été étudié pour analyser l’effet des nutrients, du support inerte et de l’eau. Les résultats obtenus confirment l’importance de ces trois paramères pour la production élevée de penicilline. Grâce au suivi analytique des effluents gazeux de la FMS on a pu détecter de légers changements dans le métabolisme de Penicillium chrysogenum et correler des variations respirometriques au début et à; la fin de la production de la pénicilline. Ainsi, il a été démontré que les conditions environnementales permettant de fortes productions de penicilline étaient celles qui induisaient des faibles taux respiratoires.
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© 1997 Springer Science+Business Media Dordrecht
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Mejía, A., Tomasini, A., Barrios-González, J. (1997). Application of on -line measurement of oxygen uptake and carbon dioxide evolution to penicillin production in solid state fermentation. In: Roussos, S., Lonsane, B.K., Raimbault, M., Viniegra-Gonzalez, G. (eds) Advances in Solid State Fermentation. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0661-2_34
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DOI: https://doi.org/10.1007/978-94-017-0661-2_34
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