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The Effect of Hydrodynamics on Biological Materials

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Advances in Bioprocess Engineering

Abstract

The delicacy of biological materials with respect to extremes of temperature, pH and/or mechanical forces is a distinguishing feature of many bioprocesses. In mainstream chemical processes, particles are often inherently robust, or might be modified to improve their behaviour in this respect. On the other hand, biological materials are usually fragile and easy damaged by hydrodynamic or “shear” forces in processing. They are not easily modified for robustness. Because of this problem, research on this aspect of biological performance is essential, and yet it is strewn with pitfalls for the unwary, and much published work in this field is flawed to some extent. Even the term “shear damage” is problematic. It is fine as a shorthand for hydrodynamic or fluid-mechanical damage, but its use has not always resulted in clear thinking about the underlying processes. Although this may seem a trivial point, it is symptomatic of deeper problems, some of which will be described later.

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Authors and Affiliations

  1. School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

    Colin R. Thomas & Zhibing Zhang

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  1. Colin R. Thomas
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  2. Zhibing Zhang
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  1. Institute of Biotechnology, National University of Mexico (UNAM), Cuernavaca, Morelos, Mexico

    Enrique Galindo  & Octavio T. Ramírez  & 

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Thomas, C.R., Zhang, Z. (1998). The Effect of Hydrodynamics on Biological Materials. In: Galindo, E., Ramírez, O.T. (eds) Advances in Bioprocess Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0643-8_9

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  • DOI: https://doi.org/10.1007/978-94-017-0643-8_9

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