Abstract
The aim of this contribution is to discuss some new aspects in the design of structured models for stirred tank bioreactors. The modelling strategy starts from a simple multiphase compartment model, which is based on an aggregation of well-mixed multiphase compartiments including mass transfer between the phases. In order to incorporate the available information of intrinsic fluid dynamics it is necessary to put finite volume elements in the place of these compartments. The fluxes from and into those elements can be estimated from the real fluid dynamics. Numerical solutions of the set of momentum equations for gas and liquid phase are shown along with application examples for a biological model (oxygen sensitive culture of Bacillus subtilis) and a physico-chemical model for pH-calculation.
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Literature Cited
Reuss, M. and R.K. Bajpai. Stirred tank models. In: H.-J. Rehm et al. (Eds.), Biotechnology, Vol. 4, VCH Verlagsgesellschaft, Weinheim-Deerfield Beach/Florida-Basel, p. 299 (1991).
Reuss, M. and M. Jenne. Compartment Models. In: U. Mortensen and H.J. Noorman (Eds.), Bioreactor Performance, Proc. The Biotechnology Research Foundation, IDEON, S-22370 Lund, Sweden, p. 63 (1993)
Ragot, F. and M. Reuss. A multi-phase compartment model for stirred bioreactors incorporating mass transfer and mixing. In: M. Reuss et al. (Eds.), Biochemical Engineering-Stuttgart, Gustav Fischer Verlag, Stuttgart, New York, p. 184 (1991)
Patankar, S.V. Numerical heat transfer and fluid flow. Mc Graw-Hill (1980)
Trägardh, C. A hydrodynamic model for the simulation of an aerated agitated fed-batch fermentation. In: Bioreactor fluid dynamics, Elsevier Applied Science Publ., 117 (1988)
Morud K. and B.H. Hjertager. Computational fluid dynamics simulation of bioreactors. In: Bioreactor Performance (Eds.: Mortensen, U., Noorman, H.). The Biotechnology Research Foundation, IDEON, S-22370 Lund, Sweden (1993)
Issa, R.I and A.D. Gosman. The computation of three-dimensional turbulent two-phase flows in mixer vessels. Numerical methods in laminar and turbulent flow, 829 (1981)
Patankar, S.V. and D.B. Spalding. Int. Journal of Heat and Mass Transfer, 15, 1787 (1972)
Moes, J. Diss. ETH Zürich, Nr. 7875 (1985)
Moes, J., M. Griot, J. Keller, E. Heinzle. I.J. Dunn and J.R. Bourne, Biotechnol. Bioeng., 27, 482 (1985)
Dunn, I.J. and E. Heinzle. Types of Understanding in Scaleing Down and Up, as Illustrated with an Oxygen-Sensitive Culture. In: U. Mortensen and H.J. Noorman (Eds.), Bioreactor Performance, Proc. The Biotechnology Research Foundation, IDEON, S-22370 Lund, Sweden, p. 189 (1993)
Kawase, Y. and M. Moo-Young. The Chem. Eng. J., 43, 19 (1990)
Pons, M.N., J.L. Greffe and J. Bordet. Talanta. 30, 205 (1983)
Pons, M.N., L. Garrido-Sanchez, P. Dantigny and J.M. Engasser. Bioproc. Eng. 5, 1 (1990)
Belfares, L. Diss. Inst. Nat. Polytechnique de Lorraine (1991)
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© 1994 Springer Science+Business Media Dordrecht
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Reuss, M., Schmalzriedt, S., Jenne, M. (1994). Structured Modelling of Bioreactors. In: Galindo, E., Ramírez, O.T. (eds) Advances in Bioprocess Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0641-4_29
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DOI: https://doi.org/10.1007/978-94-017-0641-4_29
Publisher Name: Springer, Dordrecht
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