Abstract
Fed-batch experiments in a 20 l fermentor utilizing Penicillium chrysogenum IFO 8644 were conducted using a medium containing sucrose and corn steep liquor as main components. The runs were interrupted at different stages of the process – 24, 48, 72, 96 and 120 h — and broths were transferred to an agitated vessel. Power consumption under gassed and ungassed broths and volumetric oxygen transfer coefficient, kLa, were measured for various agitation speeds and aeration rates. The rheological characteristics of each broth were also determined. Power number — modified Reynolds number plots were similar to those for other non -Newtonian fluids. Michel and Miller correlation was applied for predicting gassed power drawn for all broths. A general correlation for kLa, as a function of operating variables and apparent viscosity for broths of different cultivation ages was obtained.
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© 1994 Springer Science+Business Media Dordrecht
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Badino, A.C., Barboza, M., Hokka, C.O. (1994). Power Input and Oxygen Transfer in Fed-Batch Penicillin Production Process. In: Galindo, E., Ramírez, O.T. (eds) Advances in Bioprocess Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0641-4_22
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DOI: https://doi.org/10.1007/978-94-017-0641-4_22
Publisher Name: Springer, Dordrecht
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