Abstract
Background and objectives While liver resection for metastatic disease from colorectal cancer is likely to extend survival in selected patients, the efficacy of hepatic resection as treatment for metastases from other malignancies has not yet been defined.
Methods Between 1988 and 2000, 26 hepatic resections were performed on 24 patients (two patients underwent a double resection due to recurrence), as treatment of non-colorectal metastases. One, two, five years’ overall and disease-related actuarial survival (sec. Kaplan-Meier) have been calculated.
Results No intraoperative or early post-operative deaths were reported. Seven minor (30%) and one major (5%) post operative complications occurred; the mean blood loss was 401 +/− 324 ml; in 75% of patients, no intra/post operative blood transfusion was needed. The mean post-operative hospital stay was 13.2 days (9–23).
The overall actuarial survival rate was 54% at one year, 42% at two years and 21% at five years (mean 38 ± 11 months). Survival is related to the primary tumor nature and stage.
Conclusions Hepatic resection for metastases from non-colorectal carcinoma is safe and feasible, with relatively low incidence of intra/post-operative complications, and short hospital stay. Although it achieves good results in terms of survival only in patients suffering from neuroendocrine metastases, it could also have a cytoreductive effect for other tumors.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dionigi R, Benevento A. Il fegato. In Dionigi R. (eds):“ Chirurgia” Milano: Masson, 1998: 1261–1270.
Foster JH, Lundy J. Liver metastases. Curr Probl Surg 1981; 18: 161–201.
Dionigi R, Madiaraga J (eds.). “New technologies for liver resection”. New York: Landes, 1998.
Hughes K, Simon R et al. Registry of hepatic metastases. Resection of the liver for colorectal carcinoma metastases: a multi-istitutional study for indication of resection. Surgery 1988; 103: 278–287.
Wolf RF, Goodnight JE, Krag DE et al. Results of resection and proposed guidelines for patient selection in instanced of noncolorectal hepatic metastases. Gynec Obstet 1991; 173: 454–460.
Mariette D, Fagniez PL. Hepatic metastasis of non-colorectal cancers. Result of surgical treatment. Rev Prat 1992; 42: 1271–1275.
Chen H, Hardacre JM, Uzar A et al. Isolated liver metastases from neuroendocrine tumors: Does resection prolong survival? JAm Coll Surg 1998; 187: 88–93.
Cozzi PJ, Englund R, Morris D. Cryotherapy treatment of patients with hepatic metastases from neuroendocrine tumors. Cancer 1995; 73: 501–519.
Lang H, Oldhafer KJ, Weimann A et al. Liver transplantation for metastatic neuroendocrine tumors. Ann Surg 1997; 225: 347–354.
LeTreut YP, Delpero JR, Dousset B et al. Result of liver transplantation for metastatic neuroendocrine tumors: a 31-case French multicentric report. Ann Surg 1997; 225: 355–364.
Siperstein AE, Rogers SJ, Hansen PD et al. Laparoscopie thermal ablation of hepatic neuroendocrine tumor metastases. Surgery 1997; 12: 1147–1155.
Frame J, Kelson D, Kemeny N et al. A phase II trial of streptocin and adriamycin in advanced APUD tumor. Am J Clin Oncol 1988; 11: 490–495.
Moertal CG, Kvols D, O’Connell MJ et al. Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin: evidence of major therapeutic activity in the anaplastic variants of this neoplasm. Cancer 1991; 68: 227–232.
Perry LJ, Stuart K, Stokes KR et al. Hepatic arterial chemoembolization for metastatic neuroendocrine tumors. Surgery 1994; 166: 1111–1117.
Ochiai T, Sasako M, Mizuno S et al. Hepatic resection for metastatic tumors from gastric cancer: analysis of prognostic factors. BrJSurg 1991; 78: 797–801.
Holm A, Bradley E, Aldrete JS. Hepatic resection of metastases from colorectal carcinoma: morbidity, mortality and pattern of recurrence. Ann Surg 1989; 209: 428–434.
Ekberg H, Tranberg KG, Andersson T et al. Determinants of survival in liver resection for colorectal secondaries. Br J Surg 1986; 73: 727–731.
Isono T, Miyazaki M, Udagawa I et al. The clinicopathological study of intrahepatic micro-metastases of gastric cancer and colorectal cancer. J JPN Soc Cancer Therapy 1992; 27: 893–898.
Miyazaki M, Itoh H, Nakagawa K et al. Hepatic resection of liver metastases from gastric carcinoma. Am J Gastroenterol 1997; 97: 490–493.
Elias D, Lasser PH, Montruccoli D, et al. Hepatectomy for liver metastases from breast cancer. Eur J Surg Oncol 1995; 21 (5): 510–513.
Elias D, Lasser P, Spielmann M et al. Surgical and chemotherapeutic treatment of hepatic metastases from carcinoma of the breast. Surg Gyncol Obstet 1991; 172: 461–464.
Schneebaum S, Walker M, Young D et al. The regional treatment of liver metastases from breast cancer. J Surg Oncol 1994; 55: 26–32.
Shwartz SI. Hepatic resection for non colorectal non neuroendocrine metastases. World J Surg 1995; 19: 72–75.
Harris J, Morrow M, Norton L. Malignant tumors of the breast. In: DeVita VT Jr, Hellman S, Rosemberg SA, (eds) “Cancer: Principles and Practice of Oncology”. Philadelphia: Lippiconcott-Raven, 1997: 1557–1616.
Fumoleau P. Treatment of patients with liver metastases. Anticancer Drugs 1996; 7: 21–23.
Alexander HR, Kelsen DG, Tepper JC. Cancer of the stomach. In: DeVita VT Jr, Hellman S, Rosemberg SA, (eds.) “Cancer: Principles and Practice of Oncology”. Philadelphia: Lippiconcott-Raven, 1997; 1054–87.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Benevento, A., Boni, L., Dionigi, G., Dionigi, R. (2002). Hepatic Metastases from Non Colorectal Cancer: Which Ones Should be Resected?. In: Farinon, A.M. (eds) Advances in Abdominal Surgery 2002. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0637-7_8
Download citation
DOI: https://doi.org/10.1007/978-94-017-0637-7_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-6135-5
Online ISBN: 978-94-017-0637-7
eBook Packages: Springer Book Archive