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Radiobiological Effects of Highly Charged Ions

Their relevance for tumor therapy and radioprotection in space

  • Chapter
The Physics of Multiply and Highly Charged Ions

Abstract

The radiobiological effects of highly-charged-ion beams are of interest for tumortherapy and for radioprotection in space. In tumor therapy, high-energy protons and carbon ions exhibit an inverse dose profile, i.e. an increase of energy deposition with penetration depth. This allows a greater tumor dose for protons and carbon ions than for photons. In addition, for the heavier carbon ions, this increase in dose is potentiated by a greater relative biological efficiency (RBE). On the other hand, the greater RBE of particles is the concern of space-radioprotection because the radiation burden of the cosmic galactic radiation consists of heavy charged particles from protons to iron ions. In this chapter, the physical and biological basis of particle radiotherapy and its present status will be presented. For space radioprotection, the particle spectrum will be given and the risk of cancer induction and long-term genetic mutation will be discussed. In contrast to the cell inactivation problem for tumor therapy, where physics-based models have been developed, the genetic changes are more complex in their mechanisms and only rough estimations can be given for the time being.

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Authors and Affiliations

  1. Biophysik, Gesellschaft fur Schwerionenforschung, Planckstr. 1, 64291, Darmstadt, Germany

    G. Kraft

  2. Technische Universitat Darmstadt, Germany

    G. Kraft

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  1. G. Kraft
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Editors and Affiliations

  1. Department of Physics, The Queen’s University, Belfast, Northern Ireland

    Fred J. Currell

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Kraft, G. (2003). Radiobiological Effects of Highly Charged Ions. In: Currell, F.J. (eds) The Physics of Multiply and Highly Charged Ions. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0542-4_5

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  • DOI: https://doi.org/10.1007/978-94-017-0542-4_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6402-8

  • Online ISBN: 978-94-017-0542-4

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