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Prevention of Skin Cancer pp 195–209Cite as

Skin cancer induction by UV radiation: molecular UV targets and quantitative risk models

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Part of the book series: Cancer Prevention — Cancer Causes ((CPCC,volume 3))

Abstract

Cancer research is making great strides in the fundamental understanding of how a normal cell can turn malignant, i.e., proliferate and spread uncontrollably. The relevant changes (carcinogenic “events”) that lead to cancer can be detected or even quantified in terms of frequency of occurrence. In animal experiments on UV-induced skin cancers, the relation between such early carcinogenic events and wavelength, exposure and lapse of time can be studied in great detail. Epidemiology revealed the importance of solar (UV) exposure in the etiology of human skin cancer (see Chapters 5, 6) and early carcinogenic events can, in principle, also be detected in humans. Quantitative risk models can be refined and improved by integrating these experimental and epidemiological data. Such refined and detailed quantitative models are, however, in their infancy.

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Author information

Authors and Affiliations

  1. Dermatology, Leiden University Medical Center, Leiden, The Netherlands

    Frank R. de Gruijl Ph.D.

  2. Lab. For Radiation Research, National Institute for Public Health and Environment, Bilthoven, The Netherlands

    Harry Slaper Ph.D.

Authors
  1. Frank R. de Gruijl Ph.D.
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  2. Harry Slaper Ph.D.
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Editor information

Editors and Affiliations

  1. Centre for Behavioural Research in Cancer, The Cancer Council Victoria, Melbourne, Victoria, Australia

    David Hill Ph.D.

  2. National Cancer Control Initiative, Melbourne, Victoria, Australia

    J. Mark Elwood M.D., D.Sc.

  3. Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia

    Dallas R. English Ph.D.

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© 2004 Springer Science+Business Media Dordrecht

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de Gruijl, F.R., Slaper, H. (2004). Skin cancer induction by UV radiation: molecular UV targets and quantitative risk models. In: Hill, D., Elwood, J.M., English, D.R. (eds) Prevention of Skin Cancer. Cancer Prevention — Cancer Causes, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0511-0_11

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  • DOI: https://doi.org/10.1007/978-94-017-0511-0_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6346-5

  • Online ISBN: 978-94-017-0511-0

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