Abstract
Sulphur containing secondary compounds of plant origin are known to have therapeutic utility. Innumerable clinical aspects of these compounds are reported. These range from anticancer, anti-HIV, antifungal to several other effects. Some sulphur metabolites have shown very promising results. Compounds like organosulphur found in family Alliaceae have cardiovascular and antineoplastic effects. Sulphur containing organoselenium compounds are reported to have antineoplastic effect. Sulphated polysaccharides showed anti-HIV activity. Sulphoraphane and glucosinolates have potent anticancer activity.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anthony A (1997) Drugs of Natural Origin: Economic and Policy Aspect of Discovery, Development and Marketing. The Pharmaceutical Press, New York
Ariga T, Oshiba S and Tamada T (1981) Platelet aggregation inhibitor in garlic. Lancet 1: 150–151
Augusti KT (1977) Hypocholesterolemic effect of garlic, Allium sativum L. Indian JExp Biol 15: 489–490
Beecher CWW (1994) Cancer prevention properties of varieties of Brassica oleracea. Am J Clin Nutr 59: 11166–11705
Berthold HK, Sudhop T and Von Bergmann K (1998) Effect of garlic oil preparation on serum lipoproteins and cholestrol metabolism. A randomized controlled trial. JAMA 279: 1900–1902
Beuchat LR (1994) Antimicrobial properties of spices and their essential oils, Natural Antimicrobial System and Food Prevention, pp 167–169, CAB International, Wallingford
Bhattacharya R (2000) Antidotes to cyanide poisoning: Present Status. Indian JPharmacology 32: 94–101
Bird SM, Uden PC, Tyson JF, Block E and Denoyer ER (1998) High performance liquid chromatography of selenoamino acids and organoselenium compounds speciation by inductively coupled plasma mass spectrometry. J Chromatography 12: 785–788
Block E (1988) The organosulphur and organoselenium components of garlic and onions. In: Weyne RB (ed) Phytochemical, pp 129–141. Technomic Publisher Lancaster, Pennysylvania
Block E, Ahmad S, Catalfamo JL, Jain MK and Apitz-Castro R (1986) Antithrombotic organosulphur compounds from garlic. Structural mechanistic and synthetic studies. JAm Chem Soc 108: 7045–7055
Bordia A, Verma SK and Srivastava KC (1998) Effect of garlic (Allium sativum) on blood lipid, blood sugar, fibrinogen, fibrinolytic activity in patients with coronary artery disease. Prostagland Leukotr essen Fatty Acids 58: 257–263
Boullin DJ (1981) Garlic as a platelet inhibitor. Lancet 1: 776–777
Caporaso N, Smith SM and Eng RHK (1982) Antifungal activity in human urine and serum after ingestion of garlic. Antimicrob Agents Chemother 23: 700–702
Cavallito CJ, Bailey JH and Buck JS (1945) The antibacterial priniple ofAllium sativum. III. Its precursor and essential oil of garlic. JAm Chem Soc 67: 1032–1033
De Wit JC, Noterman S, Gorin N and Kampelmacher EH (1979) Effect of garlic oil or onion oil on toxin production by Clostridium botulinum in meat slurry. J Food Protect 42: 222–224
Douglas A (2000) Pharmacognosy in 21’ centuary. JPharmacy Pharmacology 53: 135–148
Freeman GG and Whenham RJ (1975) A survey of volatile components of some Allium species in terms of S-alk (en)yl-L-cysteine sulphoxides present as flavour procursor. JSci FoodAgric. 26: 1989–1888
Gao X, Dinkova AT and Talalay P (2001) Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes and mouse leukemia cells against oxidative danage. Indirect antioxidant effects of sulphoraphane. Proc Natl Acad Sci USA 98: 15221–15226
Gross HB, Dalebout T, Gmbh CD and Abel S (2000) Functional detection of chemopreventive glucosinolates in Arabidopsis thaliana. Plant Sci 159: 265–272
Henkel T, Brunne RM, Muller H and Reichel F (1999) Statistical investigation into the structural complementarity of natural products and synthetic compounds. Angew Chem Int 38: 643–647
Hoen T, Rooseboom M, Bijsterbosch MK, van Berkel TJ, Vermeulen NP and Commandeur JN (2002) Induction of glutathione-S-transferease mRNA level by chemopreventive selenocysteine-Se conjugate. Biochem Pharmacol 63: 1843–1849
Hu X, Benson PJ, Srivastava SK, Xia H, Bleicher RJ and Zaren HA (1997) Induction of glutathione-Stransferase as a bioassay for the evaluation of potency of inhibitors of benzophyrene-induced cancer in a murine model. Int J Cancer 73: 897–901
Ip C, Lisk DJ and Stoewsand GS (1992) Mammary cancer prevention by regular garlic and selenium-enriched garlic. Nutr Cancer 17: 279–286
Kameoka H, Demizu Y, Iwase Y and Miyazawa M (1978) Structure of cyclic sulphur compounds from Allium genus. Tennen Yuki Kagobutsu Toronkai Koen Yoshihu 21: 199–205
Kitty C (1988) A complete guide to maintaining health and treating illness with plants. Leopard Book, London
Koch HP and Lawson LD (1996) Garlic. The science and therapeutic application of Allium Sativum L. and related species. 2nd Ed PP 329, Williams and Wilkins, Baltimore
Kornilaeva GA, Makarova TV, Ganzazade AI (1995) Sulphated chitosan derivatives as HIV-infection inhibitors. Immunology 1: 13–16
Komilaeva GA, Mescheryakova DV, Ganzazade AI (1996) The V3 loop and C-terminus of gp I20 HIV-1 are the target of the anti-viral action of sulphated polysaccharides. Abstract of 4`“ International Confernce of AIDS, cancer, and human retrovirus, pp 74, Petersburg, Russia
Ledezma E, Desousa L, Jorquera A, Sanchez J, Lander A, Rodriguez E, Jain MK and Apitz-Castro R (1996) Efficiency of ajoene an organosulphur derived from garlic in the short-term therapy of Tinia pedis. Mycoses 39: 393–395
Lednicer D and Snader KM (1998) Sulfated polysaccharides. In: Wagner H. (ed) Economic Medicinal Plant Research, Vol. 5, pp 13–16, 217–218. Academy Press,Harcourt Bracl Jovanovich Publishers, London.
Lu J, Pei H and Ip C (1996) Effect of an aqueous extract of selenium enriched garlic on in vitro markers and in vivo efficacy in cancer prevention. Carcinogenesis 9: 1903–1907
Musk SR, Smith TK and Johnson IT (1995) On the cytotoxicity and genotoxicity of allyl and phenethyl isothiocyanate and their parent glucosinolates sinigrin and gluconasturtiin. Mutat Res 348: 19–23
Nagan F, Chang S and Tabba H (1988) Isolation, purification and partial characterization of an active anti-HIV compund from the Chinese medicinal herb Viole yedoensio. Antiviral Res 10: 107–116
Neushul (1990) Antiviral carbohydrate from marine red algae. Hydrobiologia 204/205: 99–104 Rich GE (1982) Garlic an antibiotic. Med JAust l: 60
Richmond VL (1986) sulphur cycle of ocean plants. JNutr 116 54–59
Ross IA (1998) Medicinal plants of the world. Chemical constituents, traditional and modem medicinal uses. Album sativum. Humana Press. Totowa, NJ
Seo YR, Sweeney C and Smith ML (2002) Selenomethione induction of DNA repair response in human fibroblast. Oncogene 21: 3663–3669
Shapiro, Fahay JW, Wade KL, Stephenson KK and Talalay P (2001) Chemoprotechtive glucosinolates and isothiocyantes of Broccoli sprouts: Metablosim and extraction in Humans. Cancer Epidemiol Biomarkers Prevention 10: 501–508
Smith TK, Lund EK and Johnson IT (1998) Inhibition of dimethyl hydrazine-induced aberrant crypt foci and induction of apoptosis in rat colon following oral administration of glucosinolate sinigrin. Carcinogenesis 19: 267–273
Spare CG and Virtanen AI (1964) Occurrence of free selenium-containing amino acids in onion (Allium cepa). Acta Chem Scand 18: 280–282
Stoewsand GS (1995) Bioactive organosulphur phytochemicals in Brassica oleraceae vegetables. Mutat Res 348: 19–23
Suzuki T, Sugii M, Kakimoto T and Tsuboi N (1961) Isolation of S-allyl-L-cysteine from garlic. Chem Pharm 9: 251–252
Takada N, Matsuda T and Otoshi T (1994) Enhancement by organosulphur compounds from garlic and onions of diethyl nitrosamine-induced glutathione S-transferase positive foci in rat liver. Cancer Res 54: 2895–2899
Wagner H (ed) (1998) Economic medicinal Plant Resaerch. Academy Press Harcort Brace Jovanovich Publishers.
Wargovich MJ, Woods C, hollis DM, Zander ME (2001) Herbals: Cancer prevention and health. J Nutr 131(11 suppl): 21–22
Zhang Y, Talalay P, Cho CG and Posner GH (1993) Food and Cancer Prevention: Chemical and Biological Aspects. In: Waldron KW, Johnson IT and Fenwick (eds) pp 429. Royal Society of Chemistry, Cambridge
Zhang Y, Thomas WK, Cheon GC, Gary HP and Talalay P (1994) Anticarcinogenic activities of sulforaphane and structurally related synthetic norbomyl isothiocyanates. Proc Natl Acad Sci USA 91: 3147–3150
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Haq, K., Ali, M. (2003). Biologically Active Sulphur Compounds of Plant Origin. In: Abrol, Y.P., Ahmad, A. (eds) Sulphur in Plants. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0289-8_21
Download citation
DOI: https://doi.org/10.1007/978-94-017-0289-8_21
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-6276-5
Online ISBN: 978-94-017-0289-8
eBook Packages: Springer Book Archive