Abstract
A hydrophilic material absorbs water vapour from its surroundings. If this material forms an airborne particle with a density larger than unit density the particle increases in size and decreases in density due to the water uptake. The larger the relative humidity rh in the air surrounding the particle the larger becomes the particle. It grows in size with increasing rh. If the particle is a droplet at zero rh and composed — for instance — of sulphuric acid or ethanol the particle grows monotonously with increasing rh. In case of a crystalline material the particle grows only above a certain value of rh, the deliquescence point. At this rh the crystalline particle becomes a droplet.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anselm, A. Untersuchungen zum Verhalten hygroskopischer Aerosolteilchen im Atemtrakt des Menschen. Ph. D. Thesis, University of Frankfurt am Main, 1989.
Berglund, R. N. and B. Y. H. Liu. Generation of Monodisperse Aerosol Standards. Env. Sci. Techn. 7: 147–152, 1973.
Cotes J. E. Lung Function Assessment and Application in Medicine. Blackwell Scientific Publications, Oxford 1979.
Ciba-Geigy. Wissenschaftliche Tabellen Geigy. Teilband Hämatologie und Humangenetik. Ciba-Geigy Limited, Basle, CH, 1979.
Ferron, G. A., B. Haider, and W. G. Kreyling. Inhalation of salt aerosol particles — I. Estimation of the temperature and relative humidity of the air in the human upper airways. J. Aerosol Sci. 19: 343–363, 1988a.
Ferron, G. A., W. G. Kreyling, and B. Haider. Inhalation of salt aerosol particles — II. Growth and deposition in the human respiratory tract. J. Aerosol Sci. 19: 611–631, 1988b.
Gebhart, J., J. Hey der, C. Roth, and W. Stahlhofen. Optical Size Spectrometry Below and Above the Wavelength of Light. Fine Particles (editor: B.Y.H. Liu), Academic Press, New York: 794–815, 1976.
Gebhart, J., G. Heigwer, J. Heyder, C. Roth, and W. Stahlhofen. The Use of Light Scattering Photometry in Aerosol Medicine. J. Aerosol Med. 1: 89–112, 1988.
Heyder, J. Charting Human Thoracic Airways by Aerosols. Clin. Phys. Physiol. Meas. 4: 29–37, 1983.
Palmes, E.D., C. Wang, M. Goldring, and B. Altshuler. Effect of Depth of Inhalation on Aerosol Persistance during Breathholding. J. Appl. Physiol. 34: 356–362, 1973.
Rosenthal, F. S. Aerosol Recovery following Breathholding derived from Distribution of Chord Lengths in Pulmonary Tissue. J. Aerosol Sci. 20: 267–277, 1989.
Seemann, S., B. Busch, G. A. Ferron, A. Silberg, and J. Heyder. Measurements of the Hygroscopicity of Pharmaceutical Aerosols in situ. J. Aerosol Sci. 26: S537–538, 1995.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Heyder, J., Gebhart, J., Roth, C., Ferron, G.A. (2003). Transport and Deposition of Hydrophilic Drug Particles in the Lungs — Experiment and Theory —. In: Gradoń, L., Marijnissen, J. (eds) Optimization of Aerosol Drug Delivery. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0267-6_8
Download citation
DOI: https://doi.org/10.1007/978-94-017-0267-6_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-6436-3
Online ISBN: 978-94-017-0267-6
eBook Packages: Springer Book Archive