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Transport and Deposition of Hydrophilic Drug Particles in the Lungs — Experiment and Theory —

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Book cover Optimization of Aerosol Drug Delivery

Abstract

A hydrophilic material absorbs water vapour from its surroundings. If this material forms an airborne particle with a density larger than unit density the particle increases in size and decreases in density due to the water uptake. The larger the relative humidity rh in the air surrounding the particle the larger becomes the particle. It grows in size with increasing rh. If the particle is a droplet at zero rh and composed — for instance — of sulphuric acid or ethanol the particle grows monotonously with increasing rh. In case of a crystalline material the particle grows only above a certain value of rh, the deliquescence point. At this rh the crystalline particle becomes a droplet.

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© 2003 Springer Science+Business Media Dordrecht

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Heyder, J., Gebhart, J., Roth, C., Ferron, G.A. (2003). Transport and Deposition of Hydrophilic Drug Particles in the Lungs — Experiment and Theory —. In: Gradoń, L., Marijnissen, J. (eds) Optimization of Aerosol Drug Delivery. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0267-6_8

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  • DOI: https://doi.org/10.1007/978-94-017-0267-6_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6436-3

  • Online ISBN: 978-94-017-0267-6

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