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Megalin, cubilin and immunoglobulin light chains: receptor-mediated uptake of light chains in kidney proximal tubule

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Monoclonal Gammopathies and the Kidney

Abstract

Megalin and cubilin are two large endocytic membrane receptors expressed in several tissues but with the highest expression in the renal proximal tubule. The two receptors mediate the endocytic uptake of a large number of substances filtered in the renal glomeruli including proteins, vitamins and trace elements bound to their carrier proteins.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark

    H. Birn, M. Leboulleux & E. I. Christensen

  2. Laboratorie d’Immunologie, INSERM U25, Hôpital Necker, Paris, France

    M. Leboulleux & P. Aucouturier

  3. Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

    S. K. Moestrup

  4. Unité de Recherches de Nephrologie Normale et Pathologique, INSERM Unité 489, Hôpital Tenon, France

    P. M. Ronco

Authors
  1. H. Birn
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  2. M. Leboulleux
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  3. S. K. Moestrup
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  4. P. M. Ronco
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  5. P. Aucouturier
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  6. E. I. Christensen
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Editor information

Editors and Affiliations

  1. University Hospital, Poitiers, France

    Guy Touchard

  2. Tenon Hospital, Paris, France

    Pierre Aucouturier  & Pierre Ronco  & 

  3. Necker Hospital, Paris, France

    Olivier Hermine

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© 2003 Springer Science+Business Media Dordrecht

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Birn, H., Leboulleux, M., Moestrup, S.K., Ronco, P.M., Aucouturier, P., Christensen, E.I. (2003). Megalin, cubilin and immunoglobulin light chains: receptor-mediated uptake of light chains in kidney proximal tubule. In: Touchard, G., Aucouturier, P., Hermine, O., Ronco, P. (eds) Monoclonal Gammopathies and the Kidney. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0191-4_4

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  • DOI: https://doi.org/10.1007/978-94-017-0191-4_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6199-7

  • Online ISBN: 978-94-017-0191-4

  • eBook Packages: Springer Book Archive

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