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Excitation-Contraction Coupling in Cardiac Muscle

  • Chapter
Molecular Control Mechanisms in Striated Muscle Contraction

Part of the book series: Advances in Muscle Research ((ADMR,volume 1))

Abstract

Excitation-contraction coupling concerns the processes linking electrical excitation of the surface membrane to contraction. As shown in Fig. 1 A, the action potential produces a systolic increase of calcium that then activates contraction. This chapter will focus on the control of calcium and will largely ignore the contractile protein mechanisms that follow the increase of Ca. These events are described in detail in other chapters. Equally, on grounds of space, we will largely ignore the whole field of pharmacological modulation of e-c coupling. The reader is directed to the following books for recent summaries of the broad field of cardiac electrophysiology and contraction (Bers, 2001;Zipes & Jalife, 2000;Sperelakis et al., 2001). An overview of cellular Ca handling is shown in Fig. 1A.

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Authors and Affiliations

  1. Unit of Cardiac Physiology, The University of Manchester, 1.524 Stopford Building Oxford Road, Manchester, M13 9PT, UK

    A. W. Trafford & D. A. Eisner

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  1. A. W. Trafford
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  2. D. A. Eisner
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Editors and Affiliations

  1. University of Illinois at Chicago, Chicago, Illinois, USA

    R. John Solaro

  2. University of Wisconsin Medical School, Madison, Wisconsin, USA

    Richard L. Moss

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© 2002 Springer Science+Business Media Dordrecht

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Trafford, A.W., Eisner, D.A. (2002). Excitation-Contraction Coupling in Cardiac Muscle. In: Solaro, R.J., Moss, R.L. (eds) Molecular Control Mechanisms in Striated Muscle Contraction. Advances in Muscle Research, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9926-9_2

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  • DOI: https://doi.org/10.1007/978-94-015-9926-9_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6069-3

  • Online ISBN: 978-94-015-9926-9

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