Molecular Models and the Articulation of Structural Constraints in Chemistry

  • Eric Francoeur
Part of the Boston Studies in the Philosophy and History of Science book series (BSPS, volume 222)


Since the development of structural theory and stereochemistry in the mid to late 19th century, to understand a molecular compound, to account for its physical and chemical properties, has been very much a matter of knowing and understanding its structure. The notion of molecules as discrete three-dimensional structures, a theoretical construct developed through and mobilized in the process of accounting for the properties of matter, has proven over time to be, by all accounts, a heuristically powerful formal gloss.


Molecular Model Steric Hindrance Polypeptide Chain Rockefeller Foundation Fibrous Protein 
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  1. Arndt, U. W. “Charles William Bunn.” Biographical Memoirs of the Fellows of the Royal Society 37 (1991): 69–83.Google Scholar
  2. Astbury, W. T. Letter to Messrs Soupham Wood, Ltd., 12/04/1940. W. T. Astbury Papers, Brotherton Library, University of Leeds.Google Scholar
  3. Astbury, W. T. “Proteins.” Chemistry and Industry 60 (1941): 491–497.Google Scholar
  4. Bailey, M. J., K. Schulten, and Johnson J. E. “The Use of Solid Physical Models for the Study of Macromolecular Assembly.” Current Opinion in Structural Biology 8, no. 2 (1998): 202–208.CrossRefGoogle Scholar
  5. Barry, Andrew. “On Interactivity: Consumers, Citizens and Culture.” In The Politics of Display: Museums, Science, Culture, edited by Sharon Macdonald, 98–117. London: Routledge, 1998.Google Scholar
  6. Becker, Bernard. “The Application of Molecular Models to Proteins and Other Structural Problems.” Senior Thesis, Princeton, 1941.Google Scholar
  7. Bernal, J. D. “The Pattern of Linus Pauling’s Work in Relation to Molecular Biology.” In Structural Chemistry and Molecular Biology, edited by Alexander Rich and Norman Davidson. San Francisco: W. H. Freeman, 1968.Google Scholar
  8. Bragg, Lawrence W. “First Stages in the X-Ray Analysis of Proteins.” Reports on Progress in Physics 28 (1965): 1–14.CrossRefGoogle Scholar
  9. Bragg, Lawrence W., John C. Kendrew, and Max F. Perutz. “Polypeptide Chain Configurations in Crystalline Proteins.” Proceedings of the Royal Society of London 203A (1950): 321–57.CrossRefGoogle Scholar
  10. Branson, Herman. Letter to Dr Mrs Goertzel, 24/05/1984. Communicated to author by H. Branson.Google Scholar
  11. Brooks, Jr., F. P., M. Ouh-Young, J. J. Batter, and P. J. Kilpatrick. “Project Grope: Haptic Displays for Scientific Visualization.” Computer Graphics 24, no. 4 (1990): 165–170.CrossRefGoogle Scholar
  12. California Institute of Technology. “Division of Chemistry and Chemical Engineering: Progress Report to the Rockefeller Foundation on the Development of Chemistry-Biology Program.” Rockefeller Foundation Archives, Collection RF, Record Group 1.2, Series 2050, Box 4, Folder 24, 1947.Google Scholar
  13. California Institute of Technology, News Bureau. Press Release: Proteins, 09/04/1951. Rockefeller Foundation Archives, Collection RF, Record Group 1.2, Series 205D, Box 4, Folder 27.Google Scholar
  14. Corey, Robert B., and Linus Pauling. “Molecular Models of Amino Acids, Peptides, and Proteins.” The Review of Scientific Instruments 24 (1953): 621–627.CrossRefGoogle Scholar
  15. Crick, Francis. “Is Alpha-Keratin a Coiled Coil?” Nature 170 (1952): 882–883.CrossRefGoogle Scholar
  16. Crick, Francis. What Mad Pursuit: A Personal View of Scientific Discovery. New York: Basic Books, 1988.Google Scholar
  17. Crowfoot, D., C. W. Bunn, B. W. Rogers-Low, and A. Turner-Jones. “The X-Ray Crystallographic Investigation of the Structure of Penicillin.” in The Chemistry of Penicillin, edited by Hans T. Clarke, John R. Johnson and Sir Robert Robinson, 310–67. Princeton: Princeton University Press, 1949.Google Scholar
  18. de Chadarevian, Soraya, and Nick Hopwood, eds. Displaying the Third Dimension: Models in the Sciences, Technology and Medicine. Stanford: Stanford University Press, forthcoming. Dowling, Deborah. “Experimenting on Theories.” Science in Context 12, no. 2 (1999): 261–273.Google Scholar
  19. Ferguson, Eugene S. Engineering and the Mind’s Eye. Cambridge: The MIT Press, 1992. Ferguson, Eugene S, Eugene S. Engineering and the Mind’s Eye. Cambridge: The MIT Press, 1992. Ferguson, Eugene S. “The Mind’s Eye: Nonverbal Thought in Technology.” Science 197 (1977): 827–836.CrossRefGoogle Scholar
  20. Francoeur, Eric. “Beyond Dematerialization and Inscription: Does the Materiality of Molecular ModelsGoogle Scholar
  21. Really Matter?“ Hyle 6, no. I (2000): available from—ed01/Hyle /Hyle6/hyle6_1.htm.Google Scholar
  22. Francoeur, Eric. “The Forgotten Tool: A Socio-Historical Analysis of the Development and Use of Mechanical Molecular Models in Chemistry and Allied Disciplines.” Ph.D. thesis, McGill, 1998.Google Scholar
  23. Francoeur, Eric. “The Forgotten Tool: The Design and Use of Molecular Models.” Social Studies of Science 27, no. 1 (1997): 7–40.CrossRefGoogle Scholar
  24. Francoeur, Eric, and Jerome Segal. “From Physical to Virtual Models: Macromolecular Structures and the Origins of Interactive Molecular Graphics.” In Displaying the Third Dimension: Models in the Sciences, Technology and Medicine.,edited by Soraya de Chadarevian and Nick Hopwood. Stanford: Stanford University Press, forthcoming.Google Scholar
  25. Goertzel, Ted, and Ben Goertzel. Linus Pauling: A Life in Science and Politics. New York: Basic Books, 1995.Google Scholar
  26. Hager, Thomas. Force of Nature: The Life of Linus Pauling. New York: Simon Schuster, 1995.Google Scholar
  27. Herman, Zelek S. “The Twenty-Five Most Cited Publications of Linus Pauling.” In The Roots of Molecular Medicine, edited by Linus Pauling and Richard Huemer. New York: W. H. Freeman, 1986.Google Scholar
  28. Hoffmann, Roald, and Pierre Laszlo. “Representation in Chemistry.” Diogenes, no. 147 (1989): 23–51.CrossRefGoogle Scholar
  29. Hopwood, Nick. —Giving Body’ to Embryos: Modeling, Mechanism and the Microtome in Late Nineteenth-Century Anatomy.“ Isis 90 (1999): 462–496.Google Scholar
  30. Huggins, Maurice L. “The Structure of Fibrous Proteins.” Chemical Reviews 32 (1943): 195–218.CrossRefGoogle Scholar
  31. Kay, Lily E. The Molecular Vision of Life: Caltech, the Rockefeller Foundation, and the Rise of the New Biology, Monographs on the History and Philosophy of Biology. New York: Oxford Univ. Press, 1993.Google Scholar
  32. Koltun, Walter L. “Precision Space-Filling Atomic Models.” Biopolymers 3 (1965): 665–79.CrossRefGoogle Scholar
  33. Laszlo, Pierre. La parole des choses ou le language de la chimie. Paris: Hermann, 1993.Google Scholar
  34. Latour, Bruno. “Drawing Things Together.” In Representation in Scientific Practice, edited by Michael Lynch and Steve Woolgar, 19–68. Cambridge, Mass.: The MIT Press, 1990.Google Scholar
  35. Latour, Bruno. Pandora’s Hope: Essays on the Reality of Science Studies. Cambridge, Mass.: Harvard Univ. Press, 1999.Google Scholar
  36. Low, Barbara. Letter to Linus Pauling, 05/23/1952. Ava Helen and Linus Pauling Papers, Oregon State University Library.Google Scholar
  37. Low, Barbara. “The Structure and Configuration of Amino Acids, Peptides and Proteins.” in The Proteins, edited by Hans Neurath and Kenneth Bailey, 235–392. New York: Academic Press, 1953.Google Scholar
  38. Low, Barbara. “X-Ray Crystallographic Measurements in the Penicillin Series.” D. Phil., Somerville College, 1948.Google Scholar
  39. Low, Barbara, and R. S. Baybutt. “The rt—Helix — A Hydrogen Bonded Configuration of the Polypeptide Chain.” Journal of the American Chemical Society 74 (1952): 5806–5807.CrossRefGoogle Scholar
  40. Low, Barbara, and J. M. Waldram. “Parallel Light Device for `Trial and Error’ Fourier Analysis.” Journal of Scientific Instruments and of Physics in Industry 26, no. 9 (1949): 311.CrossRefGoogle Scholar
  41. Lynch, Michael. “The Production of Scientific Images: Vision and Re-Vision in the History, Philosophy, and Sociology of Science.” Communication and Cognition 31, no. 2/3 (1998): 213–228.Google Scholar
  42. Mack (Jr.), Edward. “A Scaled Model of a Proposed Protein Structure.” Ohio Journal of Science 41 (1941): 183–189.Google Scholar
  43. Mack (Jr.), Edward. “The Spacing of Non-Polar Molecules in Crystal Lattices. The Atomic Domain of Hydrogen. A New Feature of Structure of the Benzene Ring.” Journal of the American Chemical Society 54 (1932): 2141–2165.Google Scholar
  44. Magat, Michel. “Über die Wirkungsradien gebundener Atome und den Orthoeffekt beim Dipolmoment.” Zeitung für Physikalische Chemie B 16 (1932): 1–18.Google Scholar
  45. Meyer, Edgar, and Norma Field Funkhouser. “A Brief History of Networking in the U. S.” Journal of Chemical Information and Computer Sciences 38, no. 6 (I998): 951–955.Google Scholar
  46. Mirsky, A. E., and L. Pauling. “On the Structure of Native, Denaturated, and Coagulated Proteins.” Proceedings of the National Academy of Science 22 (1936): 439–447.CrossRefGoogle Scholar
  47. Neurath, Hans. “Intramolecular Folding of Polypeptide Chains in Relation to Protein Structures.” Journal of Physical Chemistry 44 (1940): 296–305.CrossRefGoogle Scholar
  48. Olby, Robert. The Path to the Double Helix. New York: Dover, 1994.Google Scholar
  49. Ouh-Young, M., D. V. Beard, and J. Frederick P. Brooks. Brooks. “Force Display Performs Better Than Visual Display in a Simple 6d Docking Task.” Paper presented at the IEEE International Conference on Robotics and Automation, Scottsdale, AZ 1989.Google Scholar
  50. Ouh-Young, M., M. Pique, J. Hughes, N. Srinivasan, and F. P. Brooks, Jr. “Using a Manipulator for Force Display in Molecular Docking.” Paper presented at the IEEE International Conference on Robotics and Automation, Philadelphia, PA 1988.Google Scholar
  51. Pauling, Linus. Letter to Barbara W. Low, 07/21/1952. Ava Helen and Linus Pauling Papers, Oregon State University.Google Scholar
  52. Pauling, Linus. “Modern Structural Chemistry.” Science 123, no. 3190 (1956): 255–258.CrossRefGoogle Scholar
  53. Pauling, Linus. The Nature of the Chemical Bond. Ithaca, NY: Cornell University Press, 1939.Google Scholar
  54. Pauling, Linus, and Robert B. Corey. “Configurations of Polypeptide Chains with Favored Orientations around Single Bonds: Two New Pleated Sheets.” Proceedings of the National Academy of Sciences 37 (1951): 72–79.Google Scholar
  55. Pauling, Linus, Robert B. Corey, and H. R. Branson. “The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain.” Proceedings of the National Academy of Sciences 37 (1951): 205–211.CrossRefGoogle Scholar
  56. Perutz, Max. Letter to Sir Harold (Mrc), 04/06/1953. Public Record Office (United Kingdom), file PRO FD 1 /426.Google Scholar
  57. Pickering, Andrew. The Mangle of Practice: Time, Agency Science. Chicago: University of Chicago Press, 1995.Google Scholar
  58. Platt, John R. “The Need for Better Macromolecular Models.” Science 131 (1960): 1309–1310.CrossRefGoogle Scholar
  59. Ramsay, O. Bertrand. “Molecular Models in the Early Development of Stereochemistry.” In Van’t Hoff–Le Bel Centennial, edited by O. Bertrand Ramsay, 74–96. Washington, DC: American Chemical Society, 1975.CrossRefGoogle Scholar
  60. Ramsay, O. Bertrand. “Molecules in Three Dimensions (I).” Chemistry 47, no. 1 (1974a): 6–9.Google Scholar
  61. Ramsay, O. Bertrand. “Molecules in Three Dimensions (II).” Chemistry 47, no. 2 (1974b): 6–11.Google Scholar
  62. Ramsay, O. Bertrand. Stereochemistry. London: Heyden, 1981.Google Scholar
  63. Rheinberger, Hans-Jörg. “Representation(s).” Studies in the History and Philosophy of Science 25, no. 4 (1994): 647–654.Google Scholar
  64. Rheinberger, Hans-Jörg. Toward a History of Epistemic Things. Stanford: Stanford University Press, 1997.Google Scholar
  65. Richards, F. M. “Whatever Happened to the Fun? An Autobiographical Investigation.” Annual Review of Biophysics and Biomolecular Structure 26 (1997): 1–25.CrossRefGoogle Scholar
  66. Richards, Frederic M. “The Matching of Physical Models to Three-Dimensional Electron-Density Maps: A Simple Optical Device.” Journal of Molecular Biology 37 (1968): 2–25.Google Scholar
  67. Richardson, Jane S., et al. “Looking at Proteins: Representations, Folding, Packing, and Design.” Biophysical Journal 63 (1992): 1186–1209.CrossRefGoogle Scholar
  68. Smith, Laurence D., Lisa A. Best, D. Alan Stubbs, John Johnston, and Andrea Archibald Bastiani. “Scientific Graphs and the Hierarchy of the Sciences: A Latourian Survey of Inscriptions Practices.” Social Studies of Science 30, no. I (2000): 73–94.Google Scholar
  69. Soojung-Kim Pang, Alex. “Visual Representation and Post-Constructivist History of Science.” Historical Studies in the Physical and Biological Sciences 28, 1 (1997): 139–171.Google Scholar
  70. Stuart, Herbert A. “Über neue Molekülmodelle.” Zeitschrift für Physikalische Chemie 27B (1934): 350–358.Google Scholar
  71. Svitil, Kathy A. “A Touch of Science.” Discover, June 1998.Google Scholar
  72. Taylor, Hugh S. “Large Molecules through Atomic Spectacles.” Proceedings of the American Philosophical Society 85 (1941): 1–12.Google Scholar
  73. Topper, David. “Towards an Epistemology of Scientific Illustrations.” In Picturing Knowledge, edited by Brian S. Baigne, 215–49. Toronto: University of Toronto Press, 1996.Google Scholar
  74. Walton, Anne. Molecular and Crystal Structure Models. Chichester, Hants: Ellis Horwood, 1978. Watson, James. The Double Helix. New York: Atheneum, 1968.Google Scholar
  75. Wrinch, D. M. “The Pattern of Proteins.” Nature 137 (1936): 411–412.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Eric Francoeur
    • 1
  1. 1.Max Planck Institute for the History of ScienceBerlinGermany

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