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Fedoroff’s Translation of Mcclintock: The Uses of Chemistry in the Reorganization of Genetics

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Part of the book series: Boston Studies in the Philosophy and History of Science ((BSPS,volume 222))

Abstract

Discussions of reduction in the philosophy of science have had little to say about the role played by modes of representation in scientific discourse. Once we admit that modes of representation are conceptually essential, and not merely decorative, features of scientific thought and discourse, the question of what happens to modes of representation when scientific fields are brought into a novel alignment (involving various partial integrations and subordinations) becomes compelling. The case discussed in this essay presupposes the “reduction” of biology to chemistry that produced molecular biology, and studies in particular the effect of translating problems that arose in genetics into the idiom of molecular biology, that is, a specific “reduction” of genetics to molecular biology. I try to show that this novel alignment of fields is accompanied by an important shift in modes of representation, and that the latter play a central role in the clarification and solution of the engendering problems.

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References

  • Bhushan, N., and S. Rosenfeld, eds. Of Minds and Molecules: New Philosophical Perspectives on Chemistry. New York & Oxford: Oxford University Press, 2000.

    Google Scholar 

  • Carnap, Rudolf. The Logical Structure of the World: Pseudoproblems in Philosophy. Berkeley: University of California Press, 1937/1967.

    Google Scholar 

  • Darden, Lindley, and Nancy Maull. “Interfield Theories.” Philosophy of Science 44 (1977): 43–64. Emerson, R.A. “The Frequency of Somatic Mutation in Variegated Pericarp in Maize.” Genetics 14 (1929): 488–511.

    Google Scholar 

  • Fedoroff, Nina. “Structure of Deletion Derivatives of a Recombinant Plasmid Containing the Transposable Element Tn9 in the Spacer Sequence of Xenopus laevis 5S DNA.” Cold Spring Harbor Symposium on Quant. Biology 43 (1979): 1287–92.

    Article  Google Scholar 

  • Controlling Elements in Maize.“ In Mobile Genetic Elements,edited by James Shapiro, 1–63.

    Google Scholar 

  • Orlando, FI. and London: Academic Press, Inc., 1983.

    Google Scholar 

  • Transposable Genetic Elements in Maize.“ Scientific American 250 (1984): 84–98.

    Google Scholar 

  • Marcus Rhoades and Transposition.“ Genetics 150 (1998): 957–61.

    Google Scholar 

  • Fedoroff, N., and D. Botstein, eds. The Dynamic Genome: Barbara Mcclintock’s Ideas in the Century of Genetics. Cold Spring Harbor Laboratory Press, 1992.

    Google Scholar 

  • Fedoroff, N., and D. D. Brown. “The Nucleotide Sequence of the Repeating Unit in the Oocyte 5S Ribosomal DNA of Xenopus laevis.” Cold Spring Harbor Symposium on Quant. Biology 42 (1977): 1195–200.

    Article  Google Scholar 

  • Fedoroff, N. “The Nucleotide Sequence of Oocyte 5S DNA in Xenopus laevis. I. The AT-Rich Spacer.”Cell 13 (1978): 701–15.

    Google Scholar 

  • Fedoroff, N., J. Mauvais, and D. Chaleff. “Molecular Studies on Mutations at the Shrunken Locus in Maize Caused by the Controlling Element Ds.” Journal of Molecular and Applied Genetics 2 (1983): 11–29.

    Google Scholar 

  • Fedoroff, N., R. Polhman, and J. Messing. “The Nucleotide Sequence of the Maize Controlling Element Activator.” Cell37 (1984): 635–43.

    Google Scholar 

  • Fedoroff, N., M. Schlappi, and R. Raina. “Epigenetic Regulation of the Maize Spm Transposon.” Bioessays 17 (1994): 291–97.

    Google Scholar 

  • Fedoroff, N., S. Wessler, and M. Shure. “Isolation of the Transposable Maize Controlling Elements Ac and Ds.” Cell35 (Nov. 1983): 235–42.

    Google Scholar 

  • Grosholz, Emily, and Roald Hoffmann. “How Symbolic and Iconic Languages Bridge the Two Worlds of the Chemist: A Case Study from Contemporary Bioorganic Chemistry.” In Of Minds and Molecules: New Philosophical Perspectives on Chemistry, edited by N. Bhushan and S. Rosenfeld. New York & Oxford: Oxford University Press, 2000.

    Google Scholar 

  • Hempel, Carl, and P. Oppenheim. “Studies in the Logic of Explanation.” Philosophy of Science 15 (1948): 491–99.

    Google Scholar 

  • Keims, Carla. “Seeing Patterns: Models, Visual Evidence and Pictorial Communication in the Work of Barbara McClintock.” Journal of the History of Biology 32 (1999): 163–96.

    Article  Google Scholar 

  • Keller, L. Levels of Selection in Evolution. Princeton: Princeton University Press, 1999.

    Google Scholar 

  • Maxam, A. M., and W. Gilbert. “A New Method for Sequencing DNA.” Proceedings of the National Academy of Sciences USA 74 (1977): 560–64.

    Article  Google Scholar 

  • McClintock, Barbara. “Maize Genetics.” Carnegie Institution of Washington Year Book 45 (1946): 176–86.

    Google Scholar 

  • McClintock, Barbara. “Cytogenetic Studies of Maize and Neurospora.” Carnegie Institution of Washington Year Book 46 (1947): 146–52.

    Google Scholar 

  • McClintock, Barbara “Mutable Loci in Maize.” Carnegie Institution of Washington Year Book 47 (1948): 155–69.

    Google Scholar 

  • McClintock, Barbara “The Origin and Behavior of Mutable Loci in Maize.” Proceedings of the National Academy of Sciences USA 36 (1950): 344–55.

    Google Scholar 

  • McClintock, Barbara. “Induction of Instability at Selected Loci in Maize.” Genetics 38 (1953): 579–99.

    Google Scholar 

  • McClintock, Barbara. “The Control of Gene Action in Maize.” Brookhaven Symposium on Biology 18 (1965): 162–84.

    Google Scholar 

  • McClintock, Barbara. The Discovery and Characteri_ation of Transposable Elements: The Collected Papers ofBarbara McClintock. New York: Garland Publishers, 1987.

    Google Scholar 

  • Nagel, Ernest. The Structure of Science. New York: Harcourt, Brace & World, 1961.

    Google Scholar 

  • Nickles, Thomas. “Two Concepts of Inter-Theoretic Reduction.” Journal of Philosophy 70 (1973): 181–201.

    Article  Google Scholar 

  • Rhoades, Marcus. “Effect of the Dt Gene on the Mutability of the al Allele in Maize.” Genetics 23 (1938): 377–97.

    Google Scholar 

  • Rohrlich, Fritz. “Pluralistic Ontology and Theory Reduction in the Physical Sciences.” British Journal for the Philosophy of Science 39 (1988): 295–312.

    Article  Google Scholar 

  • Sanger, F., and A. R. Coulson. “A Rapid Method for Determining Sequences in DNA by Primed

    Google Scholar 

  • Synthesis with DNA Polymerase.“ Journal of Molecular Biology 94 (1975): 441–48.

    Google Scholar 

  • Sarkar, Sahotra. “Models of Reduction and Categories of Reductionism.” Synthese 91 (1992): 167–94. Scerri, Eric. “The Electronic Configuration Model, Quantum Mechanics, and Reduction.” BritishJournal for the Philosophy of Science 42 (1991): 309–25. •

    Google Scholar 

  • Schaffner, Kenneth. “Approaches to Reduction.” Philosophy of Science 34 (1967): 137–47. Shapiro, James, ed. Mobile Genetic Elements. Orlando, Fl. and London: Academic Press, Inc, 1983.

    Google Scholar 

  • Shaw, R., D. Byers, and E. Darmo. “Sponteneous Mutational Effects on Reproductive Traits of Arabidopsis thaliana.” Genetics 155 (2000): 369–78.

    Google Scholar 

  • Sklar, L. “Types of Inter-Theoretic Reductions.” British Journal for the Philosophy of Science 18 (1967): 109–24.

    Article  Google Scholar 

  • Watson, James. Molecular Biology of the Gene. New York and Amsterdam: W. A. Benjamin, Inc., 1965.

    Google Scholar 

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© 2001 Springer Science+Business Media Dordrecht

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Grosholz, E. (2001). Fedoroff’s Translation of Mcclintock: The Uses of Chemistry in the Reorganization of Genetics. In: Klein, U. (eds) Tools and Modes of Representation in the Laboratory Sciences. Boston Studies in the Philosophy and History of Science, vol 222. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9737-1_12

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  • DOI: https://doi.org/10.1007/978-94-015-9737-1_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5859-1

  • Online ISBN: 978-94-015-9737-1

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