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Localization and Translocation of Enzymes Involved in Leukotriene Biosynthesis

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Advances in Prostaglandin and Leukotriene Research

Part of the book series: Medical Science Symposia Series ((MSSS,volume 16))

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Abstract

Leukotrienes (LT) are potent proinflammatory mediators which are thought be released immediately upon extracellular stimulation. Responding to stimulation, arachidonic acid (AA) is released from phospholipids by the action of phospholipases (cPLA2, sPLA2, etc.). Once liberated form the phospholipid, AA is further metabolized to LTA4 by 5-lipoxygenase (5-LO). LTA4 hydrolase (LTA4H) catalyzes the transformation of LTA4 to LTB4, and LTC4 synthase adds glutathione to LTA4 and produces LTC4, which is subsequently transformed to LTD4 and LTE4 by gamma-GTP and dipeptidase, respectively and sequentially [1].

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References

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Authors
  1. Yoshiyuki Ide
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  2. Hiromi Hanaka
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  3. Tetsuya Hirabayashi
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  4. Takao Shimizu
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  5. Takashi Izumi
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Editor information

Editors and Affiliations

  1. Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institute, S-171 77, Stockholm, Sweden

    Bengt Samuelsson

  2. Department of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti , Giancarlo C. Folco  & S. Nicosia ,  & 

  3. Center for Cardiopulmonary Pharmacology, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    Giancarlo C. Folco

  4. Karolinska Hospital, Stockholm, Sweden

    E. Granström

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© 2001 Springer Science+Business Media Dordrecht

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Ide, Y., Hanaka, H., Hirabayashi, T., Shimizu, T., Izumi, T. (2001). Localization and Translocation of Enzymes Involved in Leukotriene Biosynthesis. In: Samuelsson, B., Paoletti, R., Folco, G.C., Granström, E., Nicosia, S. (eds) Advances in Prostaglandin and Leukotriene Research. Medical Science Symposia Series, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9721-0_7

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  • DOI: https://doi.org/10.1007/978-94-015-9721-0_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5881-2

  • Online ISBN: 978-94-015-9721-0

  • eBook Packages: Springer Book Archive

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