Abstract
The most prevalent side effect of statins are muscle pains occurring in presence but also in absence [1] of elevated creatine phosphokinase (CK). In one patient statin-induced muscular pains improved significantly after vitamin E [2]. Thereafter, examining another patient we found for the first time a pronounced increase in 8-epi-PGF2α, disappearing after withdrawal of the respective statin. Earlier it has been reported that rhabdomyolysis is associated with an increase in isoprostane (IP) formation [3]. Therefore, we assessed the IP 8-epi-PGF2α in plasma, serum, and urine after extraction and purification using a specific immunoassay.
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Sinzinger, H., Lupattelli, G., Chehne, F. (2001). Increased Isoprostane 8-epi-PGF2A in Statin-Induced Myopathy. In: Samuelsson, B., Paoletti, R., Folco, G.C., Granström, E., Nicosia, S. (eds) Advances in Prostaglandin and Leukotriene Research. Medical Science Symposia Series, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9721-0_38
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DOI: https://doi.org/10.1007/978-94-015-9721-0_38
Publisher Name: Springer, Dordrecht
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