Abstract
The cysteinyl-leukotrienes (cysLTs), LTC4, LTD4, and LTE4 are potent lipid mediators implicated mainly in acute bronchoconstriction and chronic airway inflammation in asthma [1]. Blood eosinophils from asthmatic patients synthesize increased amounts of cys-LTs. Cys-LTs, in turn, have in vitro chemoattractant activity for human eosinophils. LTD4-induced eosinophil infiltration of the airway could be blocked by the cysLT antagonist MK-571 [2].
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Rola-Pleszczynski, M., Thivierge, M., Stankova, J. (2001). Upregulation of Cysteinyl-Leukotriene 1 Receptor Expression by Interleukin-5 in Human Leukocytes. In: Samuelsson, B., Paoletti, R., Folco, G.C., Granström, E., Nicosia, S. (eds) Advances in Prostaglandin and Leukotriene Research. Medical Science Symposia Series, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9721-0_21
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DOI: https://doi.org/10.1007/978-94-015-9721-0_21
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