Abstract
Understanding the processes by which cells liberate free arachidonic acid (AA) from phospholipids is important because this is the first step in the production of the eicosanoids, which mediate a diverse set of biological events including many inflammatory responses related to diseases. It is generally accepted that the glucocorticoid steroids exert their anti-inflammatory properties, at least in part, by blocking the cell’s ability to liberate AA from membrane phospholipids. It now seems certain that the 85-kDa group IV phospholipase A2, also known as cytosolic phospholipase A2 (cPLA2), is directly involved in liberating AA from cellular phospholipids for the biosynthesis of eicosanoids, and thus it is important to understand how this enzyme is regulated in mammalian cells.
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Gelb, M.H., Hefner, Y., Börsch-Haubold, A.G., Watson, S.P. (2001). Regulation of Cytosolic Phospholipase A2 by Phosphorylation. In: Samuelsson, B., Paoletti, R., Folco, G.C., Granström, E., Nicosia, S. (eds) Advances in Prostaglandin and Leukotriene Research. Medical Science Symposia Series, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9721-0_16
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DOI: https://doi.org/10.1007/978-94-015-9721-0_16
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