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Nuclear Import of Arachidonate 5-Lipoxygenase

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Inflammation

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Abstract

Leukotrienes are lipid messenger molecules that are secreted by leukocytes to orchestrate a rapid and prolonged immune response. The enzyme 5-lipoxygenase catalyzes the rate-limiting first two steps in the synthesis of leukotrienes from arachidonic acid. Although it has long been known that 5-lipoxygenase moves from the cytoplasm to a membrane following activation, it has only recently been recognized that the enzyme may shuttle into and out of the nucleus before activation. The regulation of this movement of soluble 5-lipoxygenase between the cytoplasm and the nucleoplasm, as well as its impact on 5-lipoxygenase action, leukotriene synthesis and cell function, is only now being elucidated. This review details the state of our understanding of the nuclear import of 5-lipoxygenase and its potential importance in immunity.

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Abbreviations

AA:

arachidonic acid

FLAP:

5-lipoxygenase activating protein

5-HPETE:

5-hydroperoxyeicosatetraenoic acid

5-HETE:

5-hydroxyeicostatetraenoic acid

5-LO:

5-lipoxygenase

LT:

leukotriene

NIS:

nuclear importsequence

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Authors and Affiliations

  1. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA

    Thomas G. Brock & Annette M. Healy

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  1. Thomas G. Brock
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  2. Annette M. Healy
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Editors and Affiliations

  1. Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

    Andrzej Górski , Hubert Krotkiewski  & Michał Zimecki ,  & 

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© 2001 Springer Science+Business Media Dordrecht

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Brock, T.G., Healy, A.M. (2001). Nuclear Import of Arachidonate 5-Lipoxygenase. In: Górski, A., Krotkiewski, H., Zimecki, M. (eds) Inflammation. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9702-9_7

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  • DOI: https://doi.org/10.1007/978-94-015-9702-9_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5852-2

  • Online ISBN: 978-94-015-9702-9

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