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Differential Patterns of T Cell Chemokine Receptor Expression in Human Th1- and Th2-Associated Diseases

  • Chapter
Inflammation

Abstract

The interaction between chemokines and their receptors is an important step in the control of leukocyte migration into sites of inflammation. Chemokines also mediate a variety of effects independent of chemotaxis, including induction and enhancement of Thl- and Th2-associated cytokine responses. Recent studies have shown that human Th1 and Th2 clones, activated under polarizing conditions with polyclonal stimuli in vitro, display distinct patterns of chemokine receptor expression: Thl clones preferentially express CCR5 and CXCR3, while many Th2 clones express CCR4, CCR8 and, to a lesser extent, CCR3. These differential patterns of chemokine receptor expression suggest a mechanism for selective induction of migration and activation of Thl- and Th2-type cells during inflammation and, perhaps, normal immune homoeostasis. Studies have begun to examine T cell chemokine receptor expression in vivo to determine the relevance of these in vitro observations to human Th1- and Th2-associated diseases. In this review, we critically examine recent reports of T cell chemokine receptor expression in human autoimmune disorders (multiple sclerosis and rheumatoid arthritis) and atopic disorders (allergic rhinitis and asthma) which are believed to arise from inappropriate Thl- and Th2-dominated responses, respectively.

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Abbreviations

CCR:

CC chemokine receptor

CXCR:

CXC chemokine receptor

CSF:

cerebrospinal fluid

IFN:

interferon

IL:

interleukin

IP:

10 interferon-γ-induced protein of 10 kDa

TAC:

interferon induced T cell α chemoattractant

MCP:

monocyte chemotactic protein

MDC:

monocyte derived chemokine

Mig:

monokine induced by interferon γ

MIP:

macrophage inflammatory protein

MS:

multiple sclerosis

RA:

rheumatoid arthritis

RANTES:

regulated upon activation normal T cell expressed and secreted

SLC:

secondary lymphoid tissue chemokine

TARC:

thymus and activation—regulated chemokine

Th:

T helper.

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Authors and Affiliations

  1. Department of Immunology, University of Manitoba, Winnipeg, Canada

    J. Darren Campbell & Kent T. Hayglass

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  1. J. Darren Campbell
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  2. Kent T. Hayglass
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Editors and Affiliations

  1. Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

    Andrzej Górski , Hubert Krotkiewski  & Michał Zimecki ,  & 

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Campbell, J.D., Hayglass, K.T. (2001). Differential Patterns of T Cell Chemokine Receptor Expression in Human Th1- and Th2-Associated Diseases. In: Górski, A., Krotkiewski, H., Zimecki, M. (eds) Inflammation. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9702-9_3

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  • DOI: https://doi.org/10.1007/978-94-015-9702-9_3

  • Publisher Name: Springer, Dordrecht

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