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News on immunologically active plant polysaccharides

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Bioactive Carbohydrate Polymers

Part of the book series: Proceedings of the Phythochemical Society of Europe ((PPSE,volume 44))

Abstract

The medicinal use of plant polysaccharides as immunostimulatory, antitumoral or antiinflammatory agents has been hampered by the lack of bioavailability studies, by the scarce information available on the mechanism of action as well as the lack of studies on structure activity relationships in this class of compounds. Investigations of the possible mechanisms of action behind the noted inflammatory activity of polysaccharides have revealed that, beside influence on the complement cascade, endocrinal functions and cytokine induction, the effect on chemotaxis of leucocytes has to be considered as one important factor. In order to clarify the mechanism in pharmacological and clinical trials binding and resorption studies are needed. As a prerequisite for such studies we have developed methods for radio-, fluorescent- and gold labelling of polysaccharides. We also present the most recent results on production of polyclonal or monoclonal antibodies against polysaccharides, which can be used for the detection and quantification of polysaccharides in biological material and fluids.

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Authors and Affiliations

  1. Institute of Pharmacy, Pharmaceutical Biology, University of Munich, Karlstr. 29, D-80333, Muenchen, Germany

    H. Wagner & S. Kraus

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  1. H. Wagner
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  2. S. Kraus
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  1. School of Pharmacy, University of Oslo, Oslo, Norway

    Berit S. Paulsen

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Wagner, H., Kraus, S. (2000). News on immunologically active plant polysaccharides. In: Paulsen, B.S. (eds) Bioactive Carbohydrate Polymers. Proceedings of the Phythochemical Society of Europe, vol 44. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9572-8_1

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  • DOI: https://doi.org/10.1007/978-94-015-9572-8_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5379-4

  • Online ISBN: 978-94-015-9572-8

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