Abstract
The development of preventive vaccines has been one of the most significant advances in the treatment of infectious diseases. It is now possible to produce vaccines to prevent many viral, bacterial and parasitic diseases. The effect of vaccine development in Human health is expressed by the erradication of some previously widespread and deadly infection diseases, like smallpox and poliomyelitis [1]. The development of vaccines has had a similar effect on veterinarian medicine, for example in the erradication of foot and mouth disease in regions where it was endemic.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
WHO. (1996) State of the world’s vaccines and immunisation. World Health Organisation, Switzerland.
Warren, H.S., Vogel, F.R. and Chedid, L.A. (1986) Current status of immunological adjuvants. Ann. Rev. Immunol., 4, 369–388.
Coughlin, R.T., Fattom, A., Chu, Ch., White, A.C. and Winston, S. (1995) Adjuvant activity of QS-21 for experimental E. coli 018 polysaccharide vaccines. Vaccine, 13, 17–21.
Unanue, E.R. (1972) The Regulatory Role of Macrophages in Antigenic Stimulation. in: Adv. Immunol. 15. Eds. Dixon, F.J., Kunkel, H.G., Academic Press, New York and London, pp. 95–157.
Morein,B. Helenius, A., Simons, K., Pettersson, R., Kääriäinen, L. and Schirrmacher, V. (1978) Effective subunit vaccines against enveloped animal virus. Nature,276, 715–718.
Gross, P.A., Ennis, F.A., Noble, G.R., Gaerlan, P.F., Davis, W.J. and Denning, C.E. (1980) Influenza vaccine in unprimed children: improved immunogenicity with few reactions following one high dose of split-product vaccine. J.Ped., 97, 56–60.
Jennings, R. Potter, C.W., Massey, P.M.O., Duerden, B.I., Martin, J. and Bevan, A.M. (1981) Responses of volunteers to inactivated Influenza virus vaccines. J Hyg,86 1–16.
Eastwood, L.M., Jennings, R., Milner, R.D.G. and Potter, C.W. (1979) Reactogenicity and immunogenicity of a surface-antigen adsorbed influenza virus vaccine in children. J. Clin. Pathol., 32, 534–537.
Kramp, W.J., Six, H.R., Drake, S. and Kasel, J.A. (1979) Liposomal Enhancement of the Immunogenicity of Adenovirus Type 5 Hexon and Fiber Vaccines. Infect. Immun., 25, 771–773.
Audibert, F., Chedid, L. and Hannoun, C. (1977) Augmentation de la response immunitaire au vaccine grippal par un glycopeptide synthetique adjuvant (N-acetyl-muramyl-L-alanyl-D-iso-glutamine). Comptes rendus hebdoadaires des seances de l’Academie des Sciences, 285, 467–470.
Crawford, C.R., Jennings, R., Bradford, N. and Potter, C.W. (1982) The effect of bacterial peptidoglycans on the immune response of hamsters to influenza virus vaccines. Clin. Exp. Immunol., 48, 739–746.
Allison, A.C. and Byars, N.E. (1992) Immunological adjuvants and their mode of action. In: Vaccines, new approaches to immunological problems. Ed. Ellis E.W., Reed Publishing, USA, pp. 431–449.
Cooper, P.D. (1994) The selective induction of different immune responses by vaccine adjuvants. In: Strategies in Vaccine Design. Ed. Ada, G.L., R.G. Landes Company, Austin, pp. 125–158.
Stewart-Tull, D.E.S. (1994) The Theory and Practical Application of Adjuvants. John Wiley and Sons Ltd., Chichester.
Powell, M.F. and Newman, M.J. (1995) Vaccine Design: The Subunit and Adjuvant Approach. Plenum Publishing Corporation, New York.
Aguado, T., Engers, H., Pang, T. and Pink, R. (1999) Novel adjuvants currently in clinical testing. Vaccine, 17, 2321–2328.
Gupta, R.K., Rost, B.E., Relyveld, E. and Siber, G.R. (1995) Adjuvant properties of aluminum and calcium compounds. In: Vaccine Design: The Subunit and Adjuvant Approach. Eds. Powell, M.F., Newman, M.J., Plenum Publishing Corporation, New York, pp. 229–248.
White, R.G. (1972) Concepts of the mechanism of action of adjuvants. In: Immunogenicity. Ed. Borek, F., Amsterdam, pp. 112–130.
Alonso, M.J., Gupta, R.K., Min, C., Siber, G.R. and Langer, R. (1994) Biodegradable microspheres as controlled-release tetanus toxoid delivery systems. Vaccine, 12, 299–306.
Nowotny, A. (1986) Beneficially active structural entities in endotoxin preparations. In: Immunobiology and Immunopharmacology of Bacterial Endotoxins. Eds. Szentivanyi, A., Friedman, H., Plenum Publishing Corporation, New York, pp. 37.
Abbas, A.K., Lichtman, A.H. and Pober, J.S. (1995) Immunologia Celular y Molecular, Ed. Interamericana McGraw-Hill.
Gupta, R.K. and Siber, G.R. (1995) Adjuvants for human vaccines-current status, problems and future prospects. Vaccine, 13, 1263–1276.
Morein, B., Sundquist, B., Hoglund, S., Dalsgaard, K. and Osterhaus, A. (1984) Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses, Nature, 308, 457–460.
Bomford, R., Stapleton, M., Winsor, S., Beesley, J.E., Jessup, E.A., Price, K.R. and Fenwick, G.R. (1992) Adjuvanticity and ISCOM formation by structurally diverse saponins. Vaccine, 10, 572–577.
Villacres-Eriksson, M., Nikkilä, T., Lövgren, K. and Morein, B. (1993) Intracellular targeting of antigen incorporated in immunostimulating complexes. Villacres-Eriksson, Ph.D. Thesis, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Johansson, M. and Lovgren-Bengtsson, K. (1999) Iscoms with different quillaja saponin component differ in their immunomodulating activities. Vaccine, 17, 2894–2900.
Roddick, J.G., Rijnenberg, A.L. and Weissenberg, M. (1992) Alterations of the permeability of liposome membranes by the solasodine-based glycoalkaloids solasonine and solamargine. Phytochem, 31, 19511954.
Keukens, E.A.J., de Vrije, T., Jansen, L.A.M., de Boer, H, Janssen, M., de Kroon, A.I.P.M., Jongen, W.M.F. and de Kruijff, B. (1996) Glycoalkaloids selectively permeabilise cholesterol containing biomembranes. Biochim. Biophys. Acta, 1279, 243–250.
Moon, C.K., Kang, N.Y., Yun, Y.P., Lee, S.H., Lee, H.A. and Kang, T.L. (1984) Effect of red ginseng crude saponin on plasma lipid levels in rats fed on a diet high in cholesterol and triglyceride. Arch. Pharmacol. Res., 7, 41–45.
Sidhu, G.S. and Oakenfull, D.G. (1986) A mechanism for the hypocholesterolaemic activity of saponins. Br. J. Nutr., 55, 643–649.
Cheeke, P.R. (1996) Biological effects of feed and forage saponins and their impacts on animal production. In: Saponins used in Food and Agriculture. Eds. Waller, G.R. and Yamasaki, K., Plenum Press, New York, pp. 47–56.
Ferreira, F., Vazquez, A., Güntner, C. and Moyna, P. (1997) Inhibition of the passive diffusion of cholic acid by the Ilex paraguariensis St. Hil. saponins. Phytotherapy Res, 11, 79–81.
Oakenfull, D. (1986) Aggregation of saponins and bile acids in aqueous solution, Aust. J. Chem., 39, 1671–1683.
Rajananthanan, P., Allard, G.S., Sheik, N.A. and Morrow, W.J. (1999) Evaluation of novel aggregate structures as adjuvants: composition, toxicity studies and humoral responses. Vaccine, 17, 715–730.
Gosmann, G. and Schenkel, P.E. (1995) Triterpenoid saponins from Ilex paraguariensis. J. Nat. Prod., 58, 438–441.
Pires, V.S., Guillaume, D., Gosmann, G. and Schenkel, P.E. (1997) Saponins from Ilex dumosa, an Ervamate (Ilex paraguariensis) Adulterating Plant. J. Agric. Food Chem., 45, 1027–1031.
Ferreira, F., Vazquez, A., Moyna, P. and Kenne, L. (1994) Foliumin: A new spirosten lactone saponin from Solanum amygdalifolium. Phytochemistry, 36, 1473–1478.
Ferreira, F., Soulé, S., Vazquez, A., Moyna, P. and Kenne, L. (1996) Structural studies of glycosides from Solanum laxum Steud. Phytochemistry, 42, 1409–1416.
Vazquez, A., Ferreira, F., Moyna, P. and Kenne, L. (1999) Further glycosides from S. amygdalifolium. Phytochem. Anal., 10, 1–4.
Dalsgaard, K. (1978) A study of the isolation and characterization of the saponin Quil A. Evaluation of its adjuvant activity, with a special reference to the application in the vaccination of cattle against foot-and-mouth disease. Acta Vet. Scand., 69, 1–40.
Kensil, C.R., Patel, U., Lennick, M. and Marciani, D. (1991) Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J. Immun!., 146, 431–437.
Höglund, S., Dalsgaard, K., Lövgren, K., Sundquist, B., Osterhaus, A. and Morein, B. (1989) ISCOMs and immunostimulation with viral antigens. In: Subcellular Biochemistry, Vol. 15. Ed. Harris, J.R. Plenum Publishing Corporation, New York, pp. 39–68.
Gupta, R.K., Relyveld, E.H., Lindblad, E.B., Bizzini, B., Ben-Efraim, S. and Gupta, C.K. (1993) Adjuvants–a balance between toxicity and adjuvanticity. Vaccine, 11, 293–306.
Takahashi, H., Takeshita, T., Morein, B., Putney, S., German, R.N. and Berzofsky, J.A. (1990) Induction of CD8’ cytotoxic T-cells by immunization with purified HIV-1 envelope protein in ISCOMs. Nature, 344, 873–875.
Yeolekar, L.R. and Banerjee, K. (1996) Preparation and characterization of immunostimulating complexes (ISCOMs) of Japanese encephalitis virus. Vaccine, 14, 1553–1559.
Howard, C.R., Sundquist, B., Allan, J., Brown, S.E., Chen, S.H. and Morein, B. (1987) Preparation and properties of immune-stimulating complexes containing hepatitis B virus surface antigen. J. Gen. Virol., 68, 2281–2289.
Ahlénius, S., Carlsson, U. and Sundquist, B. (1986) Proc 146 Wld. Congr. Dis. Cattle, 1, 1326–1327.
Kersten, G.F., van de Put, A.M., Teerlink, T., Beuvery, E.C. and Grommelin, D.J. (1988) Immunogenicity of liposomes and iscoms containing the major outer membrane protein of Neisseria gonorrhoeae: influence of protein content and liposomal bilayer composition. Infect. Immunol., 56, 16611664.
Sjolander, A., Lövgren, K., Stahl, S., Aslund, L., Hansson, M., Nygren, P.A., Larsson, M., Hagstedt, M., Wahlin, B. and Berzins, K. (1991) High antibody responses in rabbits immunized with influenza virus ISCOMs containing a repeated sequence of the plasmodium falciparum antigen Pfl 55/RESA. Vaccine, 9, 443–450.
Brugmann, M., Drommer, W., Reichl, U. and Boge, A. (1997) Iscom (Immuno Stimulating Complex)-vaccine of equine influenza virus — transmission electron microscopic investigation and literature review. DTW Dtsch. Tierartzl. Wochenschr., 104, 196–202.
Morein, B. (1988) The ISCOM antigen-presenting system. Nature, 332, 287–288.
Allison, A.C. and Byars, N.E. (1990) Adjuvants for a new generation of vaccines. In: New Generation Vaccines. Eds. Woodrow, G.C., Levine, M.M., Marcel Dekker, New York, pp. 129–140.
Sheik, N.A., Rajananthanan, P., Attard, G.S. and Morrow, W.J.W. (1999) Generation of antigen specific CD8’ cytotoxic T cells following immunization with soluble protein formulated with novel glycoside adjuvants. Vaccine, 17, 2974–2982.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Ferreira, F., Llodrá, J. (2000). Glycoside Based Adjuvants. In: Oleszek, W., Marston, A. (eds) Saponins in Food, Feedstuffs and Medicinal Plants. Proceedings of the Phythochemical Society of Europe, vol 45. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9339-7_24
Download citation
DOI: https://doi.org/10.1007/978-94-015-9339-7_24
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-5341-1
Online ISBN: 978-94-015-9339-7
eBook Packages: Springer Book Archive