Abstract
Terminalia alata (Combretaceae) is a medicinal plant employed in our indigenous system of medicine [1] known to yield tomentosic acid [2]. An ethanolic extract of the roots of T. alata showed HIV-1RT inhibitory activity. An initial solvent-solvent partition of the crude extract distributed antimicrobial activity in the benzene fraction. The present communication deals with the isolation and characterization of two new compounds designated as 2α, 19a-dihydroxy-olean-112-en-28-methylester-3β-O-rutinoside (1) and 8-C-methyl-5,7,2’,4’-tetra-O-methyl flavanone (2) along with the known substances friedelin, ß-amyrin, methyloleanolate, lupeol and leucoanthocyanidin from the roots of this plant. The compound 1 is unique in having a 19ahydroxytriterpene monocarboxylic ester of the f3-amyrin group. In a preliminary investigation, compound 1 displayed good antimicrobial activity against Escherichia coli, Vibrio cholorae, Aspergillus fumigatus, Candida albicans, Rizopus oryzae and Crysosporium pannical.
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Srivastava, S.K., Srivastava, S.D., Chouksey, B.K. (2000). A Triterpenoidal Saponin and Other New Constituents from Terminalia Alata . In: Oleszek, W., Marston, A. (eds) Saponins in Food, Feedstuffs and Medicinal Plants. Proceedings of the Phythochemical Society of Europe, vol 45. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9339-7_11
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DOI: https://doi.org/10.1007/978-94-015-9339-7_11
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