Abstract
The vertebrate heart results from complex morphological interactions between different cardiac sub-compartments, including right and left atrial and ventricular chambers. Cardiac sub-domains originate in early heart development: cardiomyocytes differentiate in an anterior-posterior gradient in the anterior lateral mesoderm prior to the formation of a transiently linear heart tube. Studies in the chick have shown that the cardiac tube contains future sub-regions of the heart arranged in series along the anterior-posterior axis [1]. Subsequently the heart tube undergoes a process of rightward looping, and the caudal inflow region is displaced dorsally and anteriorally, resulting in an embryonic heart composed of a series of sub-compartments or segments: inflow tract (IFT), embryonic atrium, atrioventricular canal (AVC), embryonic left and right ventricles and outflow tract (OFT). Subsequent growth, septation, and remodelling of these distinct cardiac segments result in the development of separate right and left atrial and ventricular chambers with independent inlets and outlets. Morphological remodelling between different cardiac sub-domains is often perturbed in congenital heart defects in man.
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© 1999 Springer Science+Business Media Dordrecht
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Kelly, R.G., Zammit, P.S., Franco, D., Moorman, A.F.M., Buckingham, M.E. (1999). Regionalization of Transcriptional Potential in the Myocardium: ‘Cardiosensor’ Transgenic Mice. In: Doevendans, P.A., Reneman, R.S., van Bilsen, M. (eds) Cardiovascular Specific Gene Expression. Developments in Cardiovascular Medicine, vol 214. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9321-2_7
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DOI: https://doi.org/10.1007/978-94-015-9321-2_7
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