Skip to main content
SpringerLink
Log in

Cell Differentiation and Secondary Metabolite Production

  • Chapter
Morphogenesis in Plant Tissue Cultures

  • 423 Accesses

Abstract

Cell or cytodifferentiation marks the structural and physiological development of cells sequestering from mitotic cycles and acquiring specific functions within a plant. This process is sometimes also referred to as cell maturation. Cytodifferentiation has been the subject of general botany for generations, but recently seems to fade from textbooks (cf. Esau, 1965, Salisbury and Ross 1985, Strasburger et al., 1991, Eschrich, 1995), since it has triggered little experimentation to analyze its nature. Rather, a modern molecular approach is needed to substantiate the significance of cytodifferentiation or maturation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amann M, Wanner G & Zenk MH (1986) Intracellular compartmentation of two enzymes of berberine biosynthesis in plant cell cultures. Planta 167: 310–320.

    CAS  Google Scholar 

  • Arroo RRJ, Develi A, Meijers H, van de Westerlo E, Kemp AK, Croes AF & Wullems GJ (1995) Effect of exogenous auxin on root morphology and secondary metabolism in Tagetes patula hairy root cultures. Physiol. Plant. 93: 233–240.

    CAS  Google Scholar 

  • Barz W & Mackenbrock U (1994) Constitutive and elicitation-induced metabolism of isoflavones and pterocarpans in chickpea (Cicer arietinum) cell suspension cultures. Plant Cell Tissue Organ Cult. 38: 199–211.

    CAS  Google Scholar 

  • Berglund T & Ohlsson BA (1992) Effects of ethylene and aminoethoxyvinylglycine on cardenolide accumulation in tissue cultures of Digitalis lanata. J. Plant Physiol. 140: 395–398

    CAS  Google Scholar 

  • Berlin J, Ruegenhagen C, Greidziak N, Kuzovkina IN, Witte L & Wray V (1993) Biosynthesis of serotonin and ß-carboline alkaloids in hairy root cultures of Peganum harmala. Phytochemistry. 33: 593–597.

    CAS  Google Scholar 

  • Berlin J, Ruegenhagen C, Kuzovkina IN, Fecker LF & Sasse F (1994) Are tissue cultures of Peganum hannala a useful model system for studying how to manipulate the formation of secondary metabolites. Plant Cell Tissue Organ Cult. 38: 289–298.

    CAS  Google Scholar 

  • Bohimann J & Eilert U (1994) Elicitor-induced secondary metabolism in Ruta graveolens L. Plant Cell Tissue Organ Cult. 38: 189–198.

    Google Scholar 

  • Brodelius P, Deus B, Mosbach K & Zenk MH (1979) Immobilized plant cells for the production and transformation of natural products. FEBS Lett. 103: 93–97.

    CAS  PubMed  Google Scholar 

  • Brodelius P (1983) Plant cell cultures. In: Mattiasson B(ed.), Immobilized Cells and Organelles. (pp. 27–55) CRC Press, Boca Raton.

    Google Scholar 

  • Brown GD (1994) Secondary metabolism in tissue cultures of Artemisia annua. J. Nat. Prod. 57: 975–977.

    CAS  Google Scholar 

  • Calvo MC, Sanchez-Gras MC (1993) Accumulation of monoterpenes in shoot-proliferation cultures of Lavandula latifolia. Plant Sci. 91: 207–212.

    Google Scholar 

  • Campbell B & Ellis BE (1992) Fungal elicitor-mediated responses in pine cell cultures: cell wall bound phenolics. Phytochemistry. 31: 737–742.

    CAS  Google Scholar 

  • Chavadej S, Brisson N, McNeil JN & DeLuca V (1994) Redirection of tryptophan leads to production of low indole glucosinolate canola. Proc. Natl. Acad. Sci. USA 91: 2166–2170.

    CAS  PubMed  Google Scholar 

  • Chilton, MD, Tepfer DA, Petit A, David C, Casse-Delbart F & Tempe J (1982) Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells. Nature 295: 432–434.

    CAS  Google Scholar 

  • Cho GH, Kim DI, Pedersen H & Chin CK (1988): Ethephon enhancement of secondary metabolite synthesis in plant cell cultures. Biotech. Prog: 4, 184–188.

    CAS  Google Scholar 

  • Ciau-Uitz R, Miranda-Ham ML, Coello-Coello J, Chi B, Pacheco LM & Loyola-Vargas VM (1994) Indole alkaloid production by transformed and non-transformed root cultures of Catharanthus roseus. In vitro Cell Dev. Biol. 30P: 84–88.

    CAS  Google Scholar 

  • Constabel F & Nassif-Makki H (1971) Betalainbildung in Beta Calluskulturen. Ber. Dtsch. Bot. Ges. 67: 201–206.

    Google Scholar 

  • Constabel F & Tyler RT (1994) Cell culture for the production of secondary metabolites. In: Vasil IK & Thorpe TA (eds), Plant Cell and Tissue Culture (pp. 271–292), Kluwer Dordrecht.

    Google Scholar 

  • Constabel F & Vasil IK (eds) (1988) Cell Culture and Somatic Cell Genetics of Plants, Vol. 5: Phytochemicals in Plant Cell Cultures. Academic Press, New York.

    Google Scholar 

  • Constabel F (1963) Ãœber die Gerbstoffe in Gewebekulturen von Juniperus communis L. Planta Med. 11: 417–421.

    CAS  Google Scholar 

  • Constabel F (1968) Dedifferenzierung von Gerbstoffzellen. Planta Med. 16: 241–247.

    Google Scholar 

  • Constabel F (1968) Gerbstoffproduction der Calluskulturen von Juniperus communis L. Planta 79: 58–64

    CAS  Google Scholar 

  • Constabel F (1969) Ãœber die Entwicklung von Gerbstoffzellen in Calluskulturen von Juniperus communis L. Planta Med. 17: 101–115.

    CAS  PubMed  Google Scholar 

  • Constabel F (1988) Principles underlying the use of plant cell fermentation for secondary metabolite production. Biochem. Cell Biol. 66: 658–664

    CAS  Google Scholar 

  • Constabel F, Rambold S, Chatson KB, Kurz WGW & Kutney JP (1981) Alkaloid production in Catharanthus roseus (L.) Don. VI. Variation in alkaloid spectra of ce111ines derived from one single leaf. Plant Cell Rep. 1: 3–5.

    CAS  Google Scholar 

  • Constabel F, Shyluk JP & Gamborg OL (1971) The effect of hormones on anthocyanin accumulation in cell cultures of Haploprappus gracilis. Planta 96: 306–316.

    CAS  Google Scholar 

  • Constabel CP & Towers GHN (1988) Thiarubrine accumulation in hairy root cultures of Chaenactis douglasii. J. Plant Physiol. 133: 67–72.

    CAS  Google Scholar 

  • Dtiarlingue A, Mamdough AM, Malfatti P, Soulie MC & Bompeix G (1995) Evidence for rishitin biosynthesis in tomato cultures. Phytochemistry. 39: 69–70.

    Google Scholar 

  • delle Monache G , de Rosa MC, Scurria R, Vitali A, Cuteri A, Monacelli B, Pasqua G & Botta B (1995) Comparison between metabolite production in cell culture and in whole plant of Maclura pomifera. Phytochemistry. 39: 575–580

    Google Scholar 

  • DeLuca V, Balsevich J, Tyler RT & Kurz WGW (1987) Characterization of a novel N-methyltransferase from Catharanthus roseus plants. Plant Cell Rep. 6: 458–461.

    CAS  Google Scholar 

  • DeLuca V, Brisson N, Balsevich J & Kurz WGW (1989) Regulation of vindoline biosynthesis in Catharanthus roseus Molecular cloning of the first and last steps in biosynthesis. In: Kurz WGW (ed.) Primary and Secondary Metabolism of Plant Cell Cultures. (pp. 154–161). Springer, Berlin.

    Google Scholar 

  • Deus-Neumann B & Zenk MH (1984) A highly selective alkaloid uptake system in vacuoles of higher plants. Planta 162: 250–260.

    CAS  Google Scholar 

  • Doerk-Schmitz K, Witte L & Alfermann AW (1994) Tropane alkaloid patterns in plants and hairy roots of Hyoscyamus albus. Phytochemistry. 35: 107–110.

    CAS  Google Scholar 

  • Draeger B, Funck B, Höler A, Mrachatz G, Nahrstedt A, Portsteffen A, Schaal A & Schmidt R (1994) Calystegines a new group of tropane alkaloids in Solanaceae. Plant Cell Tissue Organ Cult. 38: 235–240.

    CAS  Google Scholar 

  • Durzan DJ & Ventimiglia F (1994) Free taxanes and the release of bound compounds having taxane antibody reactivity by xylanase in female, haploid-derived cell suspension cultures of Taxus brevifolia. In vitro Cell. Dev. Bio. 30P: 219–227.

    CAS  Google Scholar 

  • Eberhardt TL, Bernards MA, He LF, Davin, LB, Wooten JB & Lewis NG (1993) Lignification in cell suspension cultures of Pinus taeda J. Biol. Chem. 268: 21088–21096.

    CAS  PubMed  Google Scholar 

  • Eilert U (1987) Elicitation: Methodology and aspects of application. In: Constabel F & Vasil IK (eds) Cell Culture and Somatic Cell Genetics of Plants, Vol. 4. (pp. 153–196) Academic Press, New York.

    Google Scholar 

  • Eilert U (1989) Elicitor induction of secondary metabolism in dedifferentiated and differentiated in vitro systems of Ruta graveolens In: Kurz WGW (ed.), Primary and Secondary Metabolism of Plant Cell Cultures (pp. 219–228), Springer, Berlin.

    Google Scholar 

  • Eilert U, Constabel F & Kurz WGW (1986) Elicitor-stimulation of monoterpene indole alkaloid formation in suspension cultures of Catharanthus roseus J. Plant Physiol. 126: 11–22.

    CAS  Google Scholar 

  • Eilert U, Kurz WGW & Constabel F (1985) Stimulation of sanguinarine accumulation in Papaver somniferum cell cultures by fungal elicitors. J. Plant Physiol. 119: 65–76.

    CAS  Google Scholar 

  • Endress R (1994) Plant Cell Biotechnology. Springer, Berlin.

    Google Scholar 

  • Esau K (1965) Plant Anatomy. John Wiley, New York.

    Google Scholar 

  • Eschrich W (1995) Funktionelle Pflanzenanatomie. Springer, Berlin.

    Google Scholar 

  • Facchini PJ & DeLuca V (1994) Differential and tissue specific expression of a gene family for tyrosine/DOPA decarboxylase in opium poppy. J. Biol. Chem. 269: 26684–26690.

    CAS  PubMed  Google Scholar 

  • Facchini PJ & DeLuca V (1995) Phloem-specific expression of tyrosinlDOPA decarboxylase genes and the biosynthesis of isoquinoline alkaloids in opium poppy. Plant Cell 7:

    Google Scholar 

  • Fett-Neto AG, Melanson SJ, Sakata K & DiCosmo F (1993) Improved growth and taxol yield in developing callus of Taxus cuspidata by medium composition modification. Bio/Technology 11: 731–734.

    CAS  PubMed  Google Scholar 

  • Flores HE & Filner P (1985) Hairy roots of Solanaceae as a source of alkaloids. Plant Physiol. 77: 12s.

    Google Scholar 

  • Flores HE, Yao-Rem D, Cuello-Cuello JL, Maldonado-Mendoza IE & Loyola-Vargas VM (1993) Green roots: photosynthesis and photoautotrophy in an underground plant organ. Plant Physiol. 101: 363–371.

    CAS  PubMed  Google Scholar 

  • Fontanel A & Tabata M (1987) Production of secondary metabolites by plant tissue and cell cultures, present aspects and prospects. Nestle Research News 1986/87, Nestec Ltd.,Vevey, Switzerland, pp. 47–54.

    Google Scholar 

  • Fujita Y, Hara Y, Suga C & Morimoto T (1981) Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon II: A new medium for the production of shikonin derivatives. Plant Cell Rep. 1: 61–63.

    CAS  Google Scholar 

  • Fukuda H & Komamine A (1980): Establishment of an experimental system for the study of tracheary element differentiation from single cells isolated from the mesophyll of Zinnia elegans Plant Physiol. 65: 57–60.

    CAS  PubMed  Google Scholar 

  • Fukuda H & Komamine A (1982) Lignin synthesis and its related enzymes as markers of tracheary-element differentiation in single cells isolated from the mesophyll of Zinnia elegans Planta 155: 423–430.

    CAS  Google Scholar 

  • Fulzele D, Heble MR & Rao PS (1995) Production of terpenoids from Artemisia annua L. plantlet cultures in a bioreactor. J. Biotechn. 40: 139–143.

    CAS  Google Scholar 

  • Gamborg OL & Phillips GC (eds) (1995) Fundamental Methods of Plant Cell, Tissue, and Organ Culture and Laboratory Operations. Springer, New York.

    Google Scholar 

  • Gamborg OL, Miller RA & Ojima (1968) Nutrient requirements of suspension cultures of soybean root cells. Exptl. Cell Res. 50: 151–158.

    CAS  PubMed  Google Scholar 

  • Gautheret RJ (1959) La Culture des Tissues Végétaux. Techniques et Rélization. Masson, Paris.

    Google Scholar 

  • Gertlowski C & Petersen M(1993) Influence of the carbon source on growth and rosmarinic acid production in suspension cultures of Coleus blumei Plant Cell Tissue Organ Cult. 34: 183–190.

    CAS  Google Scholar 

  • Girod PA & Zryd JP (1991) Secondary metabolism in cultured red beet (Beta vulgaris L.) cells: differential regulation of betaxanthin and betacyanin biosynthesis. Plant Cell Tissue Organ Cult. 25: 1–12.

    CAS  Google Scholar 

  • Goddijn OJM, de Kam RJ, Zanetti A, Schilperoort RA & Hoge JHC (1992) Auxin rapidly down-regulates transcription of the tryptophan decarboxylase gene from Catharanthus roseus. Plant Mol. Biol. 18: 1113–1120.

    CAS  PubMed  Google Scholar 

  • Gontier E, Sangwan BS & Barbotin JN (1994) Effects of calcium, alginate, and calcium alginate immobilization on growth and tropane alkaloid levels of a stable suspension cell line of Datura innoxia Mill. Plant Cell Rep. 13: 533–536.

    CAS  Google Scholar 

  • Green KD, Thomas NH & Callow JA (1992): Product enhancement and recovery from transformed root cultures of Nicotiana glauca Biotechnol. Bioeng. 39: 195–202.

    CAS  Google Scholar 

  • Gränicher F, Christen P & Kapetanidis I (1995) Production of Valepotriates by hairy root cultures of Centranthus ruber DC. Plant Cell Rep. 14: 294–298.

    Google Scholar 

  • Gränicher F, Christen P, Kamalaprija P & Burger U (1995) An iridoid diester from Valeriana officinalis var. sambucifolia hairy roots. Phytochemistry. 38: 103–105.

    Google Scholar 

  • Guo ZJ & Ohta Y (1993) A synergistic effect of glutathione-depletion and elicitation on the production of 6-methoxymellein in carrot cells. Plant Cell Rep. 12: 617–620.

    CAS  Google Scholar 

  • Guo ZJ & Ohta Y (1994) Effect of ethylene biosynthesis on the accumulation of 6-methoxymellein induced by elicitors in carrot cells. J. Plant Physiol. 144: 700–704.

    CAS  Google Scholar 

  • Haagendoorn NJN, Zethof JLM, van Hunnik E & van der Plas LHW (1991) Regulation of anthocyanin and lignin synthesis in Petunia hybrida cell suspensions. Plant Cell Tissue Organ Cult. 27: 141–147.

    Google Scholar 

  • Haberlandt G (1914) Physiological Plant Anatomy, MacMillan, London.

    Google Scholar 

  • Hahlbrock K & Scheel D (1989) Physiology and molecular biology of phenylpropanoid metabolism. Annu. Rev. Plant Physiol. Plant Mol. Biol. 40: 347–369.

    CAS  Google Scholar 

  • Hamill JD, Parr AJ, Robins RJ & Rhodes MJC (1986) Secondary product formation by cultures of Beta vulgaris and Nicotiana rustica transformed with Agrobacterium rhizogenes Plant Cell Rep. 5: 111–114.

    CAS  Google Scholar 

  • Hamill JD, Robins RJ, Parr AJ, Evans DM, Furze JM & Rhodes MJC (1990) Overexpressing a yeast ornithine decarboxylase gene in transgenic roots of Nicotiana rustica can lead to enhanced nicotine accumulation. Plant Mol. Biol. 15: 27–38.

    CAS  PubMed  Google Scholar 

  • Hara M, Kitamura T, Fukui H & Tabata M (1993) Induction of berberine biosynthesis by cytokinins in Thalictrum minus cell suspension cultures. Plant Cell Rep. 12: 70–73.

    CAS  Google Scholar 

  • Hara M, Morio H, Yazaki K, Tanaka S & Tabata M (1995) Separation and characterization of cytokinin-inducible (S)-tetrahydroberberine oxidases controlling berberine biosynthesis in Thalictrum minus cell cultures. Phytochemistry. 38: 89–95.

    CAS  Google Scholar 

  • Hashimoto T & Yamada Y (1994) Alkaloid biogenesis: Molecular aspects. Annu Rev. Plant Physiol. Plant Mol. Biol. 45: 257–285.

    CAS  Google Scholar 

  • Hayashi T, Gotoh K, Ohnishi K, Okamura K & Asamizu T (1995) 6-methoxy-2-benzoxazolinone in Scoparia dukis and its production by cultured tissues. Phytochemis try. 37: 1611–1614.

    Google Scholar 

  • Hirano H & Komamine A (1994) Correlation of betacyanin synthesis with cell division in cell suspension cultures of Phytolacca americana. Physiol. Plant. 90: 239–245.

    CAS  Google Scholar 

  • Hirose M, Yamakawa T, Kodama T & Komamine A (1990) Accumulation of betacyanin in Phytolacca americana cells and of anthocyanin in Vitis sp. cells in relation to cell division in suspension cultures. Plant Cell Physiol. 31: 267–271.

    CAS  Google Scholar 

  • Hirotani M, Zhou Y, Rui H & Furuya T (1994) Cycloartane triterpene glycosides from the hairy root cultures of Astragalus membranaceus. Phytochemistry. 37: 1403–1407.

    CAS  PubMed  Google Scholar 

  • Holden PR & Yoeman MM (1994) Variation in the growth and biosynthetic activity of cloned cell cultures of Capsicum frutescens and their response to an exogenously supplied elicitor. Plant Cell Tissue Organ Cul. 38, 31–37.

    CAS  Google Scholar 

  • Hook I (1994) Secondary metabolites in hairy root cultures of Leontopodium alpinum Cass. Edelweiss. Plant Cell Tissue Organ Cult. 38: 321–326.

    CAS  Google Scholar 

  • Hoshino T, Chida M, Yamaura T, Yoshizawa Y & Mizutani J (1994) Phytoalexin induction in green pepper cell cultures treated with arachidonic acid. Phytochemistry. 36: 1417–1419.

    CAS  Google Scholar 

  • Hosokawa K & Fukunaga Y (1996) Production of essential oils by flowers of Hyacinthus orientalis L. regenerated in vitro. Plant Cell Rep. In press.

    Google Scholar 

  • Häusler E, Petersen M & Alfermann AW (1993): Isolation of protoplasts and vacuoles from cell suspension cultures of Coleus blumei Benth. Plant Cell Rep. 12: 510–512.

    Google Scholar 

  • Ikemeyer D & Barz W(1989) Comparison of secondary product accumulation in photoautotrophic, photomixotrophic and heterotrophic Nicotiana tabacum cell suspension cultures. Plant Cell Rep. 8: 479–482.

    CAS  Google Scholar 

  • Ikenaga T, Oyama T & Muranaka T (1995) Growth and steroidal saponin production in hairy root cultures of Solanum aculeatissimum. Plant Cell Rep. 14: 413–417.

    CAS  Google Scholar 

  • Ikuta A, Kamiya K, Satake T & Saiki Y (1995) Triterpenoids from callus cultures of Paeonia species. Phytochemistry. 38: 1203–1207.

    CAS  Google Scholar 

  • Ionkova I, Witte L & Alfennann AW (1994) Spectrum of tropane alkaloids in transformed roots of Datura innoxia and Hyoscyamus x gyoerfyi cultivated in vitro. Planta Med. 60: 382–383.

    CAS  PubMed  Google Scholar 

  • Ishiguro K, Nakajima M, Fukumoto H & Isoi K (1995) Co-occurrence of prenylated xanthones and their cyclization products in cell suspension cultures of Hypericum patulum. Phytochemistry. 38: 867–869.

    CAS  Google Scholar 

  • Ishimaru K, Arakawa H, Yamanaka M & Shimomura K (1994) Polyacetylenes in Lobelia sessilifolia hairy roots. Phytochemistry. 35: 365–369.

    CAS  Google Scholar 

  • Jaziri M, Shimomura K, Yoshimatsu K, Fauconnier ML, Marlier M & Homes J (1995) Establishment of normal and transformed root cultures of Artemisia annua L. for artemisinin production. J. Plant Physiol. 145: 175–177.

    CAS  Google Scholar 

  • Jung KH, Kwak SS, Choi CY & Liu JR (1996) An interchangeable system of hairy root and cell suspension cultures in Catharanthus roseus for indole alkaloid production. Plant Cell Rep. 14, in press.

    Google Scholar 

  • Jung KH, Kwak SS, Choi CY & Liu JR (1994) Development of a two-stage culture process by optimization of inorganic salts for improving catharanthine production in hairy root cultures of Catharanthus roseus. J. Ferm. Bioeng. 77: 57–61.

    CAS  Google Scholar 

  • Kanegae T, Kayija H, Amano Y, Hashimoto T & Yamada Y (1994) Species-dependent expression of the hyoscyamine 6ß -hydroxylase gene in the pericycle. Plant Physiol. 105: 483–490.

    CAS  PubMed  Google Scholar 

  • Kim SW, Jung KH, Kwak SS & Liu JR (1994) Relationship between cell morphology and indole alkaloid production in cell suspension cultures of Catharanthus roseus. Plant Cell Rep. 14: 23–26.

    CAS  Google Scholar 

  • Knöss W (1994) Furanic labdane diterpenes in differentiated and undifferentiated cultures of Marrubium vulgare and Leonurus cardiaca. Plant Physiol. Biochem. 32: 785–789.

    Google Scholar 

  • Knöss W (1995) Establishment of callus, cell suspension and shoot cultures of Leonurus cardiaca L. and diterpene analysis. Plant Cell Rep. 14: 790–793.

    Google Scholar 

  • Kreis W, Heinz H, Sutor R & Reinhard E (1993) Cellular organization of cardenolide biotransformation in Digitalis grrrndiflora Mill. Planta 191: 246–251.

    CAS  Google Scholar 

  • Krombholz R, Mersinger R, Kreis W & Reinhard E (1992) Production of forskolin by axenic Coleus forskohlii roots cultivated in shake flasks and 20–1 glass jar bioreactors. Planta Med. 58: 328–333.

    CAS  PubMed  Google Scholar 

  • Kurz WGW & Constabel F (1998) Production of secondary metabolites. In: Altman A (ed.) Agricultural Biotechnologies. Marcel Dekker Inc., New York.

    Google Scholar 

  • Kutchan TM, Ayabe S, Krueger RJ, Coscia EM & Coscia CJ (1983) Cytodifferentiation and alkaloid accumulation in cultured cells of Papaver bracteatum. Plant Cell Rep. 2: 281–284.

    CAS  Google Scholar 

  • Lindsey K & Yoeman MM (1983) The relationship between growth rate, differentiation and alkaloid accumulation in cell cultures. J. Exp. Bot. 34: 1055–1065.

    CAS  Google Scholar 

  • Loyola -Vargas VM & Miranda-Ham ML (1996) Root culture as a source of secondary metabolites of economic importance. Rec. Adv. Phytochem.(in press).

    Google Scholar 

  • Luckner M, Nover L & Boehm H (1977) Secondary Metabolism and Cell Differentiation. Springer Verlag, Berlin-Heidelberg.

    Google Scholar 

  • Ma W, Park GL, Gomez GA, Nieder MH, Adams TL, Sahai OP, Smith RJ, Stahlhut RW, Hylands PJ, Bitsch F & Shackleton C (1994a) New bioactive taxoids from cell cultures of Taxus baccata. J. Nat. Prod. 57: 116–122.

    CAS  PubMed  Google Scholar 

  • Ma WW, Stahlhut RW, Adams TL, Park GL, Evans WA, Blumenthal SG, Gomez GA, Nieder MH & Hylands PJ (1994b) Yunnanxane and its homologous esters from cell cultures of Taxus chinensis var. mairei. J. Nat. Prod. 57: 1320–1324.

    CAS  PubMed  Google Scholar 

  • Mahady MG & Beecher CWW (1994): Quercetin-induced benzophenanthridine alkaloid production in suspension cell cultures of Sanguinaria canadensis. Planta Med. 60: 553–557.

    CAS  PubMed  Google Scholar 

  • Maldonado-Mendoza IE & Loyola-Vargas VM (1995) Establishment and characterization of photosynthetic hairy root cultures of Datura stramonium. Plant Cell Tissue Organ Cult. 40: 197–208.

    CAS  Google Scholar 

  • Maldonado-Mendoza IE, Ayora-Talavera TR & Loyola-Vargas VM (1992: Tropane alkaloid production in Datura stramonium root cultures. In vitro Cell Dev. Biol. 28P: 67–72.

    CAS  Google Scholar 

  • McCaskill D, Gershenzon J & Croteau R (1992) Morphology and monoterpene biosynthetic capabilities of secretory cell clusters isolated from glandular trichomes of peppermint (Mentha piperita L.) Planta 187: 445–454.

    CAS  Google Scholar 

  • McClellan D, Kott L, Beversdorf W & Ellis BE (1993) Glucosinolate metabolism in zygotic and microspore-derived embryos of Brassica napus L. J. Plant Physiol. 141: 153–159.

    CAS  Google Scholar 

  • Mersinger R, Domauer H & Reinhard E (1988) Formation of forskolin by suspension cultures of Coleus forskohlti. Planta Med. 54: 200–204.

    CAS  PubMed  Google Scholar 

  • Meyer HJ & van Staden J (1995) The in vitro production of an anthocyanin from callus cultures of Oxalis linearis. Plant Cell Tissue Organ Cult. 40: 55–58.

    CAS  Google Scholar 

  • Mita G, Gerardi C, Miceli A, Bollini R & DeLeo P (1994) Pigment production from in vitro cultures of Alkanna tinctoria Tausch. Plant Cell Rep. 13: 406–410.

    CAS  Google Scholar 

  • Miura Y, Hirata K, Kurano N, Miyamoto K & Uchida K (1988) Formation of vinblastine in multiple shoot cultures of Catharanthus roseus. Planta Med. 54: 18–20.

    CAS  PubMed  Google Scholar 

  • Mizukasi, S, Tanabe Y, Noguchi M & Tamaki E (1973) Changes in the activities of ornithine decarboxylase, putrescine N-methyltransferase and N-methyl-putrescine oxidase in tobacco roots in relation to nicotine biosynthesis. Plant Cell Physiol. 14: 103–110.

    Google Scholar 

  • Moreno PRH, van der Heijden R & Verpoorte R (1993) Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus. Plant Cell Rep. 12: 702–705.

    CAS  Google Scholar 

  • Mothes K (1972) Pflanze und Tier, ein Vergleich auf der Ebene des Sekundaerstoffwechsels. terr. Abh. Akad. Wiss. Wien, Sonderh. zu SB. Abt. I, Vol. 181.

    Google Scholar 

  • Mukherjee S, Ghosh B & Jha S (1996) Forskolin synthesis in cultures of Coleus forskohlii Briq. transformed withAgrobacterium tumefaciens. Plant Cell Rep. 15 (in press).

    Google Scholar 

  • Mlurashige T & Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant. 15: 473–479.

    Google Scholar 

  • Nakagawa K, Konagai A, Fukui H & Tabata M (1984) Release and crystallization of berberine in a liquid medium of Thalictrum minus cell suspension cultures. Plant Cell Rep. 3: 254–257.

    CAS  Google Scholar 

  • Nessler CL & von der Haar RA (1990) Cloning and expression analysis of DNA sequences for the major latex protein of opium poppy. Planta 180: 487–491.

    CAS  Google Scholar 

  • Nessler CL (1994) Sequence analysis of two new members of the major latex protein gene family supports the triploid-hybrid origin of the opium poppy. Gene 139: 207–209.

    CAS  PubMed  Google Scholar 

  • Ozeki Y & Komamine A (1994) Effects of growth regulation on the induction of anthocyanin synthesis in carrot suspension cultures. Plant Cell Physiol. 27: 1361–1368.

    Google Scholar 

  • Paech K (1950) Biochemie und Physiologie der sekundaeren Pflanzenstoffe. Springer, Berlin.

    Google Scholar 

  • Paiva NL, Oommen A, Harrison MJ & Dixon RA (1994) Regulation of isoflavonoid metabolism in alfalfa. Plant Cell Tissue Organ Cult. 38: 213–220.

    CAS  Google Scholar 

  • Park HH, Hakamatsuka T, Sankawa U & Ebizuka Y (1995) Rapid metabolism of isoflavonoids in elicitor-treated cell suspension cultures of Pueraria lobata. Phytochem istry. 38: 373–380.

    CAS  Google Scholar 

  • Pasqua G, Monacelli B, Cuteri A, Botta B, Vitali A, delle Monache G (1991) Cell suspension cultures of Maclura pomifera: Optimization of growth and metabolite production. J. Plant Physiol. 139: 249–251.

    CAS  Google Scholar 

  • Petersen M & Alfermann AW (1993) Plant cell cultures. In: Rehm HJ & Reed G (eds) Biotechnology 2nd ed. (pp. 577–614) Verlag Chemie, Weinheim.

    Google Scholar 

  • Piatti T, Boller T & Brodelius PE (1991) Induction of ethylene biosynthesis is correlated with but not required for induction of alkaloid accumulation in elicitor-treated Eschscholtzia cells. Phytochemistry. 30: 2151–2154.

    CAS  Google Scholar 

  • Razzaque A & Ellis BE (1977) Rosmarinic acid production in Coleus cell cultures. Planta 137: 287–291.

    CAS  Google Scholar 

  • Reichling J, Becker H, Martin R & Burkhardt G (1985) Comparative studies on the production and accumulation of essential oil in the whole plant and in the cell culture of Pimpinella anisum L. Z. Naturforsch. 40c: 465–468.

    CAS  Google Scholar 

  • Reichling J, Martin R & Thron U (1988) Production and accumulation of phenylpropanoids in tissue and organ cultures of Pimpinella anisum L. Z. Naturforsch. 43c: 42–46.

    Google Scholar 

  • Reinert, J (1958) Untersuchungen über die Morphogenese an Gewebekulturen. Ber. Dtsch. Bot. Ges. 71: 15.

    Google Scholar 

  • Rho D, Chauret N, Laberge N & Archambault J (1992) Growth characteristics of Sanguinaria canadensis L. cell suspensions and immobilized cultures for production of benzophenanthridine alkaloids. Appl. Microbiol. Biotechnol. 36: 611–617.

    CAS  PubMed  Google Scholar 

  • Rhodes MJC, Parr AJ, Guilietti A & Aird ELH (1994) Influence of exogenous hormones on the growth and secondary metabolite formation in transformed root cultures. Plant Cell Ti s sue Organ Cult. 38: 143–151.

    CAS  Google Scholar 

  • Roewer I, Cloutier N, Nessler CL & DeLuca V (1992) Transient induction of tryptophan decarboxylase (TDC) and strictosidine synthase (SS) genes in cell suspension cultures of Catharanthus roseus. Plant Cell Rep. 11: 86–89.

    CAS  Google Scholar 

  • Rubluo A, Flores A, Jiminez M & Brunner I (1994) Piqueria trinervia Cav.: In vitro culture and the production of piquerol. In: Bajaj YPS (ed.) Biotechnology in Agriculture and Forestry. Medicinal and Aromatic Plants. Vol. 8. Springer, Berlin.

    Google Scholar 

  • Rudat A & Ehwald R (1994) Induction of betacyanin formation in Chenopodium album cell cultures by co-cultivation with duckweed Wolfia arrhiza. Plant Cell Rep. 13: 291–294.

    CAS  Google Scholar 

  • Rush MD, Kutchan TM & Coscia CJ (1985) Correlation of tne appearance of morphinan alkaloids and laticifer cells in germinating Papaver bracteatum seedlings. Plant Cell Rep. 4: 237–240.

    CAS  Google Scholar 

  • Salem KMSA & Charlwood BV (1995) Accumulation of essential oils by Agrobacterium tumefaciens-transfonned shoot cultures of Pimpinella anisum. Plant Cell Tissue Organ Cult. 40: 209–215.

    CAS  Google Scholar 

  • Salisbury FB & Ross CW (1985) Plant Physiology. Wadsworth Publ. Comp.,Belmont/CA

    Google Scholar 

  • Sanyal MAD, Bannerjee D & Datta PC (1981) In vitro hormone induced chemical and histological differentiation in stem callus of neem Azadirachta indica A. Juss. Indian J. Exptl. Biol. 13: 84–85.

    Google Scholar 

  • Sato F, Takeshita N, Fujiwara H, Katagiri Y, Huan LP & Yamada Y (1994) Characterization of Coptis japonica cells with different alkaloid productivities. Plant Cell Tissue Organ Cult. 38: 249–256.

    CAS  Google Scholar 

  • Sato H, Tanaka S & Tabata M (1993a) Kinetics of alkaloid uptake by cultured cells of Coptis japonica. Phytochemistry. 34: 697–701.

    CAS  Google Scholar 

  • Sato K, Yamazaki T, Okuyama E, Yoshihira K & Shimomura K (1991) Anthraquinon production by transformed root cultures of Rubia tinctorum. Influence of phytohormones and sucrose concentration. Phytochemistry. 30: 1507–1509.

    CAS  Google Scholar 

  • Sato Y, Sugiyama M, Gorecki RJ, Fukuda H & Komamine A (1993b) Interrelationship between lignin deposition and the activities of peroxidase isoenzymes in differentiating tracheary elements of Zinnia. Planta 189: 584–589.

    CAS  Google Scholar 

  • Sauerwein M, Ishimaru K & Shimomura K (1991 a) Indole alkaloids in hairy roots of Amsonia elliptica. Phytochemistry. 30: 1153–1155.

    CAS  Google Scholar 

  • Sauerwein M, Yamazaki T & Shimomura K (1991 b) Hernandulcin in hairy root cultures of Lippia dulcis. Plant Cell Rep. 9: 579–581.

    CAS  Google Scholar 

  • Schuchmann R & Wellmann E (1983) Somatic embryogenesis in tissue cultures of Papaver somniferum and Papaver orientale and its relationship to alkaloid and lipid metabolism. Plant Cell Rep. 2: 88–91.

    CAS  Google Scholar 

  • Schulthess B & Baumann TW (1995) Stimulation of caffeine biosynthesis in suspensioncultured coffee cells and the in situ existence of 7-methylxanthosine. Phytochemistry. 38: 1381–1386.

    CAS  Google Scholar 

  • Seitz HU & Gaertnmer DE (1994) Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea L. Plant Cell Tissue Organ Cult. 38: 337–344.

    CAS  Google Scholar 

  • Shimomura K, Sudo H, Saga H & Kamada H (1991) Shikonin production and secretion by hairy root cultures of Lithospermum erythrorhizon. Plant Cell Rep. 10: 282–285.

    CAS  Google Scholar 

  • Smith, JI, Smart NJ, Kurz WGW & Misawa M (1987) Stimulation of indole alkaloid production in cell suspension cultures of Catharanthus roseus by abscisic acid. Planta Med. 53: 470–474.

    CAS  PubMed  Google Scholar 

  • Smolko DD & SW Peretti (1994) Stimulation of berberine secretion and growth in cell cultures of Thalictrum minus. Plant Cell Rep. 14: 131–136.

    CAS  Google Scholar 

  • Sommer S, Severin K, Camara B & Heide L (1995) Intracellular localization of geranylpyrophosphate synthase from cell cultures of Lithospermum erythrorhizon. Phytochemistry 38: 623–627.

    CAS  Google Scholar 

  • Song KS, Tomoda M, Shimizu N, Sankawa U & Ebizuka Y (1995) Mannan glycopeptide elicits p-coumaroylamino acids in Ephedra distachya cultures. Phytochemistry. 38: 95–102.

    CAS  Google Scholar 

  • Songstad DD, Giles KL, Park J, Novakovski D, Epp D, Friesen L & Roewer I (1989) Effect of ethylene on sanguinarine production from Papaver somniferum cell cultures. Plant Cell Rep. 8: 463–466.

    CAS  Google Scholar 

  • Spencer A, Hamill JD & Rhodes MJC (1993) In vitro biosynthesis of monoterpenes by Agrobacterium transformed shoot cultures of two Mentha species. Phytochemistry. 32: 9111–919.

    Google Scholar 

  • Stano J, Nemec P, Weissova K, Kovacs P, Kakoniova D & Liskova D (1995) Decarboxylation of L-tyrosine and L-DOPA by immobilized cells of Papaver somniferum. Phytochemistry. 38: 859–860.

    CAS  Google Scholar 

  • Steward FC, Mapes MO & Mears K (1958) Growth and organized development of cultured cells. II. Organization in cultures grown from freely suspended cells. Am. J. Bot. 45: 705–708.

    Google Scholar 

  • Strasburger E, Noll F, Schenck H & Schimper AFW (1991) Lehrbuch der Botanik für Hochschulen, 33rd edition by Sitte P, Ziegler H, Ehrendorfer F & Bresinsky A., Gustav Fischer Verlag, Stuttgart.

    Google Scholar 

  • Strauss A, Spengel SM & Schaffner W (1995) Saponins from root cultures of Phytolacca acinosa. Phyto chemi stry. 38: 861–865.

    CAS  Google Scholar 

  • Stuhlemmer U, Kreis W, Eisenbeiss M & Reinhard E (1993) Cardiac glycosides in partly submerged shoots of Digitalis lanata. Planta Med. 59, 539–544.

    CAS  PubMed  Google Scholar 

  • Subroto MA & Doran P (1994) Production of steroidal alkaloids by hairy roots of Solanum aviculare and the effect of gibberellic acid. Plant Cell Tissue Organ Cult. 38: 93–102.

    CAS  Google Scholar 

  • Sugimoto Y, Yoshida A, Uchida S, Inanaga S & Yamada Y (1994) Dauricine production in cultured roots of Menispermum dauricum. Phytochemistry. 36: 679–683.

    CAS  Google Scholar 

  • Suri SS & Ramawat KG (1995) In vitro hormonal regulation of laticifer differentiation in Calotropis procera. Ann Bot. 75: 477–480.

    CAS  Google Scholar 

  • Suvarnalatha G, Rajendran L, Ravishankar GA & Venkatamaran LV (1994) Elicitation of anthocyanin production in cell cultures of carrot (Daucus carota L.) by using elicitors and abiotic stress. Biotech. Lett. 16: 1275–1280.

    CAS  Google Scholar 

  • Suzuki K, Amino S, Takeuchi Y & Komamine A (1990) Differences in the composition of the cell walls of two morphologically different lines in suspension-cultured Catharanthus roseus cells. Plant Cell Physiol. 31: 7–14.

    CAS  Google Scholar 

  • Swain T (1977) Secondary compounds as protective agents. Annu. Rev. Plant Physiol. 28: 479–501.

    CAS  Google Scholar 

  • Swanson SM, Mahady GB & Beecher CWW (1992) Stevioside biosynthesis by callus, root, shoot and rooted-shoot cultures in vitro. Plant Cell Tissue Organ Cult. 28: 151–157.

    CAS  Google Scholar 

  • Tada H, Shimomura K & Ishimaru K (1995) Polyacetylenes in Platycodon grandiflorum hairy root and campanulaceous plants. J. Plant Physiol. 145: 7–10.

    CAS  Google Scholar 

  • Tam WHJ, Kurz WGW & Constabel F (1980) Codeine from cell suspension cultures of Papaver somniferum. Phytochemistry. 19: 486–487.

    CAS  Google Scholar 

  • Tanaka N, Takao M & Matsumoto T (1995) Vincamine production in multiple shoot culture derived from hairy roots of Vinca minor. Plant Cell Tissue Organ Cult. 41: 61–64.

    CAS  Google Scholar 

  • Tulecke WR & Nickell LG (1959) Production of large amounts of plant tissue by submerged culture. Science 130: 863–864.

    CAS  PubMed  Google Scholar 

  • Ushiyama K, Oda H, Miyamoto Y & Furuya T (1986) Large scale tissue culture of Panax ginseng root. Proc. 6th Congr. IAPTC, Minneapolis. Abstr. p. 252.

    Google Scholar 

  • Vazquez-Flota F, Moreno-Valenzuela O, Marinda-Ham ML, Coello-Coello J & Loyola Vargas VM (1994) Catharanthine and ajmalicine synthesis in Catharanthus roseus hairy root cultures. Plant Cell Tissue Organ Cult. 38: 273–279.

    CAS  Google Scholar 

  • Verpoorte R, van der Heijden R, Schripsema J, Hoge JHC & ten Hoopen HJG (1993) Plant cell biotechnology for the production of alkaloids: present status and prospects. J. Nat. Prod. 56: 186–207.

    CAS  Google Scholar 

  • Westcott RJ, Cheetham PSJ & Barraclough AJ (1994) Use of organized viable Vanilla plant aerial roots for the production of natural vanillin. Phytochemistry. 35: 135–138.

    CAS  Google Scholar 

  • Wetter, LR & Constabel F (1982) Plant Tissue Culture Methods, 2nd ed., National Research Council of Canada, Saskatoon.

    Google Scholar 

  • White PR (1934) Potentially unlimited growth of excised tomato root tips in a liquid medium. Plant Physiol. 9: 585–600.

    CAS  PubMed  Google Scholar 

  • Wibberley MS, Lenton JR & Neill SJ (1994) Sesquiterpenoid phytoalexins produced by hairy roots of Nicotiana tabacum. Phytochemistry. 37: 349–351.

    CAS  Google Scholar 

  • Wickremesinhe ERM & Arteca RN (1994) Taxus cell suspension cultures: optimizing growth and production of taxol. J. Plant Physiol. 144: 183–188.

    CAS  Google Scholar 

  • Williams RD, Chauret N, Bedard C & Archambault J (1992) Effect of polymeric adsorbents on the production of sanguinarine by Papaver somniferum cell cultures. Biotech Bioeng. 40: 971–977.

    CAS  Google Scholar 

  • Wink M (1994) The cell culture medium — a functional extracellular compartment of suspension-cultured cells. Plant Cell Tissue Organ Cult. 38: 307–319.

    CAS  Google Scholar 

  • Wolters B & Eilert U (1983) Elicitoren — Ausloeser der Akkumulation von Pflanzenstoffen. Ihre Anwendung zur Produktionssteigerung in Zellkulturen. Dtsch. Apotheker Ztg 123: 659–667.

    CAS  Google Scholar 

  • Yamamoto H, Suzuki M, Suga Y, Fukui H & Tabata M (1987) Participation of an active transport system in berberine-secreting cultured cells of Thalictrum minus. Plant Cell Rep. 6: 356–359.

    CAS  Google Scholar 

  • Yoshikawa T & Furuya T (1985) Morphinan alkaloid production by tissues differentiated from cultured cells of Papaver somniferum. Planta Med. 110–113.

    Google Scholar 

  • Yoshimatsu K & Shimomura K (1992) Transformation of opium poppy (Papaver somn ferum L.) with Agrobacterium rhizogenes MAFF 03–01724. Plant Cell Rep. 11: 132–136.

    CAS  Google Scholar 

  • Yukimune Y, Tabata H, Hara Y & Yamada Y (1994b) Scopolamine yield in cultured roots of Duboisia myoporoides improved by a novel two-stage culture method. Biosci. Biotechnol. Biochem. 58: 1820–1823.

    CAS  Google Scholar 

  • Yukimune Y, Tabata H, Hara Y & Yamada Y (1994a) Increase of scopolamine production by high density culture of Duboisia myoporoides roots. Biosci. Biotechnol. Biochem. 58: 1447–1450.

    CAS  Google Scholar 

  • Yukumine YH, Yamagata YH & Yamada Y (1994) Effects of oxygen on nicotine and tropane alkaloid production in cultured roots of Duboisia myoporoides. Biosci. Biotechnol. Biochem. 58: 1824–1827.

    Google Scholar 

  • Zenk MII, El-Shagi H, Arens H, Stoeckigt J, Weiler EW & Deus B (1977) Formation of indole alkaloids serpentine and ajmalicine in cell suspension cultures of Catharanthus roseus. In: Barz W, et al. (eds) Plant Tissue Culture and its Bio/Technological Application. (pp. 27–43) Springer, Berlin

    Google Scholar 

  • Zhou Y, Hirotani M, Rui H & Furuya T (1995) Two triglycosidic tciterpene astragalosides from hairy root cultures of Astragalus membranaceus. Phytochemistry. 38: 1407–1410.

    CAS  Google Scholar 

  • Zinunermann A & K Hahlbrock (1975) Light-induced changes of enzyme activities in parsley cell suspension cultures. Purification and some properties of phenylalanine ammonialyase. Arch. Biochem. Biophys. 166: 54–62.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Courtenay, BC, Canada, RR6, Site 662, C95, V9N 8H9

    F. Constabel

  2. 514 Copland Crescent, Saskatoon, SK, Canada, S7H 2Z5

    W. G. W. Kurz

Authors
  1. F. Constabel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. G. W. Kurz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Woong-Young Soh Sant S. Bhojwani

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Constabel, F., Kurz, W.G.W. (1999). Cell Differentiation and Secondary Metabolite Production. In: Soh, WY., Bhojwani, S.S. (eds) Morphogenesis in Plant Tissue Cultures. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9253-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-94-015-9253-6_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5206-3

  • Online ISBN: 978-94-015-9253-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation