Skip to main content
SpringerLink
Log in

Immunologically-mediated toxin-induced renal diseases

  • Chapter
Clinical Nephrotoxins

Abstract

Many chemicals including drugs and pollutants may induce in humans immunologically-mediated nephropathies [1–4]. Some examples are given in Table 1. The diagnosis is evoked when the disease occurs for non toxic amounts of the chemical and when only a small percentage of individuals, is affected due to both genetic (genes encoding for enzymes involved in the metabolism of the chemical or genes encoding for MHC class II molecules have been implicated) and environmental factors. The most often, priming is required and disease does not appear at the first contact. The disease improves when the chemical is withdrawn. Extrarenal manifestations such as fever, rash, hypereosinophilia and a rise in serum IgE concentration may be observed. Renal biopsies are of interest since they allow to determine the structure affected (glomeruli and tubules) and if mononuclear cells infiltrate the kidney and/or if immunoglobulins are deposited.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fillastre JP, Druet P, Mery JP Proteinuria associated with drugs and substances of abuse. In: Cameron JS, Glassock RJ, editors. The nephrotic syndrome. New York: Marcel Dekker, 1988: 697–744.

    Google Scholar 

  2. Bigazzi PE. Autoimmunity induced by chemicals. Clin Toxicol 1988; 26: 125–56.

    Article  CAS  Google Scholar 

  3. Kammüller ME, Bloksma N, Seinen W. Autoimmunity and toxicology. Immune disregulation induced by drugs and chemicals. In: Kammüller ME, Bloksma N, Seinen W, editors. Autoimmunity and Toxicology. Amsterdam: Elsevier 1989: 3–35.

    Google Scholar 

  4. Druet P, Jacquot C, Baran D, Kleinknecht D, Fillastre JP, Mery JP. Immunologically mediated nephritis induced by toxin and drugs. In: Bach Ph, Lock EA, editors. Nephrotoxicity in the experimental and clinical situation. Amsterdam: Martinus Nijhoff 1987: 727–70.

    Chapter  Google Scholar 

  5. Lin RH, Mamula MJ, Hardin JA, Janeway CA Jr. Induction of autoreactive B cells allows priming of autoreactive T cells. J Exp Med 1991; 173: 1433–9.

    Article  PubMed  CAS  Google Scholar 

  6. Merino R, Fossati L, Izui S. The lupus-prone BXSB strain: the Yaa gene model of systemic lupus erythematosus. Springer Semin Immunopathol 1992; 14: 141–57.

    Article  PubMed  CAS  Google Scholar 

  7. Kappler JW, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987; 49: 273–80.

    Article  PubMed  CAS  Google Scholar 

  8. Gill RG, Haskins KH. Molecular mechanisms underlying diabetes and other autoimmune diseases. Immunol Today 1993; 14: 49–51.

    Article  PubMed  CAS  Google Scholar 

  9. Nossal GJV. Immunologic tolerance: collaboration between antigens and lymphokines. Science 1989; 245: 147–53.

    Article  PubMed  CAS  Google Scholar 

  10. Jenkins MK. The role of division in the induction of clonal anergy. Immunol Today 1992; 13: 69–73.

    Article  PubMed  CAS  Google Scholar 

  11. Jones LA, Chin LT, Longo DL, Kruisbeek AM. Peripheral clonal elimination of functional T cells. Science 1990; 250: 1726–9.

    Article  PubMed  CAS  Google Scholar 

  12. Lo D, Freedman J, Hesse S, Brinster RL, Sherman L. Peripheral tolerance in transgenic mice: tolerance to class II MHC and non-MHC transgene antigens. Immunol Rev 1991; 122: 87–102.

    Article  PubMed  CAS  Google Scholar 

  13. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clones I. Definition according to profiles of lymphokines activities and secreted proteins. J Immunol 1986; 136: 2348–57.

    PubMed  CAS  Google Scholar 

  14. Mosmann TR, Coffman RL. Heterogeneity of cytokine suppression patterns and functions of helper T cells. Adv Immunol 1989; 46: 111–47.

    Article  PubMed  CAS  Google Scholar 

  15. Depner TA. Nephrotic syndrome secondary to lithium therapy. Nephron 1982; 30: 286–9.

    Article  PubMed  CAS  Google Scholar 

  16. Appel GB, Kunis CL. Acute tubulointerstitial. In: Cotran RS, Brenner BM, Stein JH, editors. Tubulointerstitial nephropathies. New York: Churchill Livingstone, 1983: 151–185 (Contemporary Issues in Nephrology, vol. 10).

    Google Scholar 

  17. Shaloub RJ. Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet 1974; 2: 556–9.

    Article  Google Scholar 

  18. Koyama A, Fujizaki M, Igarashi M, Narita M. A glomerular permeability factor produced by human T cell hybridomas. Kidney Int 1991; 40: 453–60.

    Article  PubMed  CAS  Google Scholar 

  19. Cho BS, Lee CE, Pyun KH. Elevation of interleukin (IL-4) activities and mRNA expression in childhood minimal change nephrotic syndrome. J Am Soc Nephrol 1991; 2: 591.

    Google Scholar 

  20. Oite T, Shimizu S, Kagami S, Morioka T. Hapten specific cellular immune response producing glomerular injury. Clin Exp Immunol 1989; 76: 463–8.

    PubMed  CAS  Google Scholar 

  21. Wooley PH, Griffin J, Panayi GS, Batchelor JR, Welsh KI, Gibson TJ. HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. N Engl J Med 1980; 303: 300–2.

    Article  PubMed  CAS  Google Scholar 

  22. Ntoso KA, Tomaszewski JE, Jimenez SA, Neilson EG. Penicillamine-induced rapidly progressive glomerulonephritis with progressive systemic sclerosis: successful treatment of two patients and a review of the litterature. Am J Kidney Dis 1986; 8: 159–63.

    PubMed  CAS  Google Scholar 

  23. Emery P, Panayi GS, Huston G, Welsh KL, Mitschell SC, Shah RR, Idle JR, Smith RL, Waring RH. D-penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation status and HLA-DR3. J Rheumatol 1984; 11: 626–32.

    PubMed  CAS  Google Scholar 

  24. Quigg RJ, Cybulsky AV, Salant DJ. Effect of nephritogenic antibody on complement regulation in cultured rat glomerular epithelial cells. J Immunol 1991; 147: 838–45.

    PubMed  CAS  Google Scholar 

  25. Kawachi H, Orisaka M, Matsui K, Iwanaga T, Toyabe S, Oite T, Shimuzu F. Epitope-specific induction of mesangial lesions with proteinuria by a MoAb against mesangial cell surface antigen. Clin Exp Immunol 1992; 88: 399–404.

    Article  PubMed  CAS  Google Scholar 

  26. Aten J, Veninga A, Bruijn JA, Prins FA, de Heer E, Weening JJ. Antigenic specificities of glomerular-bound autoantibodies in membranous glomerulopathy induced by mercuric chloride. Clin Immunol Immunopathol 1992; 63: 89–102.

    Article  PubMed  CAS  Google Scholar 

  27. Mendrick DL, Rennke HG. I. Induction of proteinuria in the rat by a monoclonal antibody against SGP-115/107. Kidney Int 1988; 33: 818–30.

    Article  PubMed  CAS  Google Scholar 

  28. Montinaro V, Hevey K, Aventaggio L, Fadden K, Esparza A, Chen A, Finbloom DS, Rifai A. Extrarenal cytokines modulate the glomerular response to IgA immune complexes. Kidney Int 1992; 42: 341–53.

    Article  PubMed  CAS  Google Scholar 

  29. Joh K, Aizawa S, Yamaguchi Y, Inomata I, Shibazaki T, Sakai O, Hamaguchi K. Drug-induced hypersensitivity nephritis: lymphocyte stimulation testing and renal biopsy in 10 cases. Am J Nephrol 1990; 10: 222–30.

    Article  PubMed  CAS  Google Scholar 

  30. Kleinknecht D, Vanhille P, Morel-Maroger L, Kanfer A, Lemaitre V, Mery JP, Laederich L, Callard P. Acute interstitial nephritis due to drug hypersensitivity. An up-to-date review with a report of 19 cases. In: Grünfeld JP, Maxwell MH, editors. Advances in Nephrology. Chicago: Year Book Medical Publishers 1983; 12: 277–308.

    Google Scholar 

  31. Ooi BS, Jao W, First MR, Mancilla R, Pollak VE. Acute interstitial nephritis. A clinical and pathologic study based on renal biopsies. Am J Med 1975; 59: 614–29.

    Article  PubMed  CAS  Google Scholar 

  32. Kleinknecht D, Landais P, Goldfarb B. Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: a prospective collaborative study. Clin Nephrol 1986; 25: 275–81.

    PubMed  CAS  Google Scholar 

  33. McCluskey RT, Bhan AK. Immunologic mechanisms in drug-induced acute interstitial nephritis. In: Porter GA, editor. Nephrotoxic mechanisms of drugs and environmental toxins. New York: Plenum Medical, 1982: 393–402.

    Chapter  Google Scholar 

  34. Linton AL, Clark WL, Driedger AA, Turnbull DI, Lindsay RM. Acute interstitial nephritis due to drugs. Review of litterature with a report of 9 cases. Ann Intern Med 1980; 93: 735–41.

    Article  PubMed  CAS  Google Scholar 

  35. Border WA, Lehman DH, Egan JD, Sass HJ, Glade JE, Wilson CB. Anti-tubular basement membrane antibodies in methicillin associated interstitial nephritis. N Engl J Med 1974; 291: 381–4.

    Article  PubMed  CAS  Google Scholar 

  36. Lehman DH, Wilson CB, Dixon FJ. Extraglomerular immunoglobulin deposits in human nephritis. Am J Med 1975; 58: 765–86.

    Article  PubMed  CAS  Google Scholar 

  37. Mayaud C, Kourilsky O, Kanfer A, Sraer JD. Interstitial nephritis after methicillin. N Engl J Med 1975; 292: 1132–5.

    PubMed  CAS  Google Scholar 

  38. Ditlove J, Weichmann P, Bernstein M. Methicillin nephritis. Medicine 1977; 56: 483–91.

    Article  PubMed  CAS  Google Scholar 

  39. Colvin RB, Burton NE, Hyslop NE. Penicillin associated interstitial nephritis. Ann Intern Med 1974; 81: 403–5.

    Article  Google Scholar 

  40. Girard JP. Common antigenic determinants of penicillin G, ampicillin and the cephalotins demonstrated in man. Int Arch Allergy Appl Immunol 1968; 33: 428–38.

    Article  PubMed  CAS  Google Scholar 

  41. Churg J, Cotran RS, Sinniah RS. Tubulointerstitial nephritis induced by immediate (IgE type) hypersensitivity. In: Churg J, Cotran RS, Sinniah RS, editors. Renal disease: classification and atlas of tubulointerstitial disease. Tokyo: Igakushoin, 1985: 82–92.

    Google Scholar 

  42. Abt AB, Gordon JA. Drug-induced interstitial nephritis: coexistence with glomerular disease. Arch Intern Med 1985; 145: 1063–7.

    Article  PubMed  CAS  Google Scholar 

  43. Rennke HG, Klein PS, Mendrick DL. Cell-mediated immunity (CMI) in hapten-induced interstitial nephritis and glomerular crescent formation in the rat. Kidney Int 1990; 37: 428.

    Google Scholar 

  44. Joh K, Shibasaki T, Azuma T, Kabayashi A, Miyahara T, Aizawa S, Watanabe N. Experimental drug-induced allergic nephritis mediated by antihapten antibody. Int Arch Allergy Appl Immunol 1989; 88: 337–44.

    Article  PubMed  CAS  Google Scholar 

  45. Prouvost-Danon A, Abadie A, Sapin C, Bazin H, Druet P. Induction of IgE synthesis and potentiation of anti-ovalbumin IgE response by HgCl2 in the rat. J Immunol 1981; 126: 699–702.

    PubMed  CAS  Google Scholar 

  46. Hirsh F, Couderc J, Sapin C, Fournie G, Druet P. Polyclonal effect of HgCl2 in the rat, its possible role in an experimental autoimmune disease. Eur J Immunol 1982; 12: 620–5.

    Article  Google Scholar 

  47. Pelletier L, Pasquier R, Guettier C, Vial MC, Mandet C, Nochy D, Bazin H, Druet P. HgCl2 induces T and B cells to proliferate and differentiate in Brown-Norway rats. Clin Exp Immunol 1988; 71: 336–42.

    PubMed  CAS  Google Scholar 

  48. Bellon B, Capron M, Druet E, Verroust P, Vial MC, Sapin C, Girard JF, Foidart JM, Mahieu P, Druet P. Mercuric chloride-induced autoimmunity in Brown Norway rats: sequential search for anti-basement membrane antibodies. Eur J Clin Invest 1982; 12: 127–33.

    Article  PubMed  CAS  Google Scholar 

  49. Pusey CD, Bowman C, Morgan A, Weetman AP, Hartley B, Lockwood CM. Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the Brown Norway rat. Clin Exp Med 1990; 81: 76–82.

    CAS  Google Scholar 

  50. Aten J, Bosman CB, Rozing J, Stijnen T, Hoedemaeker PJ, Weening JJ. Mercuric chloride-induced autoimmunity in the Brown Norway rat. Cellular kinetics and major histocompatibility complex antigen expression. Am J Pathol 1988; 133: 127–38.

    PubMed  CAS  Google Scholar 

  51. Sapin C, Druet E, Druet P. Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride. Clin Exp Immunol 1977; 28: 173–8.

    PubMed  CAS  Google Scholar 

  52. Druet P, Druet E, Potdevin F, Sapin C. Immune type glomerulonephritis induced by HgCl2 in the Brown Norway rat. Ann Immunol (Inst Pasteur) 1978; 129C: 777–92.

    Google Scholar 

  53. Druet E, Sapin C, Günther E, Feingold N, Druet P. Mercuric chloride induced anti-glomerular basement membrane antibodies in rat. Genetic control. Eur J Immunol 1977; 7: 348–51.

    Article  PubMed  CAS  Google Scholar 

  54. Aten J, Veninga A, de Heer E, Rozing J, Nieuwenhuis P, Hoedemaeker PJ, Weening JJ. Susceptibility to the induction of either autoimmunity or immunosuppression by mercuric chloride is related to the MHC class II haplotype. Eur J Immunol 1991; 21: 611–6.

    Article  PubMed  CAS  Google Scholar 

  55. Guéry JC, Druet E, Glotz D, Hirsch F, Mandet C, de Heer E, Druet P. Specificity and cross-reactive idiotypes of anti-glomerular basement membrane antibodies in HgCl2-induced autoimmune glomerulonephritis. Eur J Immunol 1990; 20: 93–100.

    Article  PubMed  Google Scholar 

  56. Robinson CJG, Abraham AA, Balazs T. Induction of antinuclear antibodies by mercuric chloride. Clin Exp Immunol 1984; 58: 300–6.

    PubMed  CAS  Google Scholar 

  57. Robinson CJG, Balazs T, Egorov IK. Mercuric chloride-, gold sodium thiomalate-, and D-penicillamine-induced anti-nuclear antibodies in mice. Toxicol Appl Pharmacol 1986; 86: 159–69.

    Article  PubMed  CAS  Google Scholar 

  58. Pietsch P, Vohr HW, Degitz K, Gleichmann E. Immuno-pathological signs inducible by mercury compounds. II. HgCl2 and gold sodium thiomalate enhance serum IgE and IgG concentrations in susceptible mouse strains. Int Arch Allergy Appl Immun 1989; 90: 47–53.

    Article  CAS  Google Scholar 

  59. Schmiedeke TMJ, Stöckl FW, Weber R, Sugisaki Y, Batsford SR, Vogt A. Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis. J Exp Med 1989; 169: 1879–94.

    Article  PubMed  CAS  Google Scholar 

  60. Eneström S, Hultman P. Immune-related glomerulonephritis induced by mercuric chloride in mice. Experien-tia 1984; 40: 1234–40.

    Article  Google Scholar 

  61. Hultman P, Eneström S. Mercury-induced antinuclear antibodies in mice: characterization and correlation with renal immune complex deposits. Clin Exp Immunol 1988; 71: 269–74.

    PubMed  CAS  Google Scholar 

  62. Donker AJ, Rocco CV, Vladutiu AO, Brentjens JR, Andres GA. Effects of prolonged administration of D-penicillamine or Captopril in various strains of rats. Brown-Norway rats teated with D-penicillamine develop autoantibodies, circulating immune complexes and disseminated intravascular coagulation. Clin Immunol Immunopathol 1984; 30: 142–55.

    Article  PubMed  CAS  Google Scholar 

  63. Tournade H, Pelletier L, Pasquier R, Vial MC, Mandet C, Druet P. D-penicillamine-induced autoimmunity in Brown-Norway rats: similarities with HgCl2-induced autoimmunity. J Immunol 1990; 144: 2985–91.

    PubMed  CAS  Google Scholar 

  64. Tournade H, Guéry JC, Pasquier R, Nochy D, Hinglais N, Guilbert B, Druet P, Pelletier L. Experimental gold-induced autoimmunity. Nephrol Dial Transplant 1991; 6: 621–30.

    Article  PubMed  CAS  Google Scholar 

  65. Guéry JC, Tournade H, Pelletier L, Druet E, Druet P. Rat anti-glomerular basement membrane antibodies in toxin-induced autoimmunity and in chronic graft-versus-host reaction share recurrent idiotypes. Eur J Immunol 1990; 20: 101–5.

    Article  PubMed  Google Scholar 

  66. Pelletier L, Pasquier R, Rossert J, Vial MC, Mandet C, Druet P. Autoreactive T cells in mercury disease. Ability to induce the autoimmune disease. J Immunol 1988; 140: 750–4.

    PubMed  CAS  Google Scholar 

  67. Pelletier L, Pasquier R, Hirsch F, Sapin C, Druet P. Autoreactive T cells in mercury-induced autoimmune disease: in vitro demonstration. J Immunol 1986; 137: 2548–54.

    PubMed  CAS  Google Scholar 

  68. Rossert J, Pelletier L, Pasquier R, Druet P. Autoreactive T cells in mercury-induced autoimmune disease. Demonstration by limiting dilution analysis. Eur J Immunol 1988; 18: 1761–6.

    Article  PubMed  CAS  Google Scholar 

  69. Castedo M, Pelletier J, Druet P. A role for autoreactive anti-class II T cells in gold salt-triggered B cell polyclonal activation in the Brown-Norway rat. J Am Soc Nephrol 1992; 3: 578.

    Google Scholar 

  70. Richardson B. Effect of an inhibitor of DNA methyla-tion on T cells. II. 5-azacytidine induces self reactivity in antigen-specific T4 + cells. Human Immunol 1986; 17: 456–70.

    Article  CAS  Google Scholar 

  71. Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988; 140: 2197–200.

    PubMed  CAS  Google Scholar 

  72. Dubey C, Bellon B, Hirsch F, Kuhn J, Vial MC, Goldman M, Druet P. Increased expression of class II major histocompatibility complex molecules on B cells in rats susceptible or resistant to HgCl2-induced autoimmunity. Clin Exp Immunol 1991; 86: 118–23.

    Article  PubMed  CAS  Google Scholar 

  73. McCabe M, Lawrence DA. The heavy metal lead exhibits B cell-stimulatory factor by enhancing B cell Ia expression and differentiation. J Immunol 1990; 145: 671–7.

    PubMed  CAS  Google Scholar 

  74. Weening JJ, Hoedemaeker PJ, Bakker WW. Immuno-regulation and anti-nuclear antibodies in mercury-induced glomerulopathy in the rat. Clin Exp Immunol 1981; 45: 64–71.

    PubMed  CAS  Google Scholar 

  75. Ochel M, Vohr HW, Pfeiffer C, Gleichmann E. IL-4 is required for the IgE and IgGl increase and IgGl autoantibody formation in mice treated with mercuric chloride. J Immunol 1991; 146: 3006–11.

    PubMed  CAS  Google Scholar 

  76. Tsutsui H, Terano Y, Sakagami C, Hasegawa I, Mizoguchi Y, Morisawa S. Drug-specific T cells derived from patients with drug-induced allergic hepatitis. J Immunol 1992; 149: 706–16.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Lucette Pelletier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Philippe Druet
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Nephrology and Hypertension, University of Antwerp, Belgium

    M. E. De Broe  & G. A. Verpooten  & 

  2. Department of Medicine, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    G. A. Porter

  3. Division of Nephrology, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    W. M. Bennett

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Pelletier, L., Druet, P. (1998). Immunologically-mediated toxin-induced renal diseases. In: De Broe, M.E., Porter, G.A., Bennett, W.M., Verpooten, G.A. (eds) Clinical Nephrotoxins. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9088-4_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-015-9088-4_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-015-9090-7

  • Online ISBN: 978-94-015-9088-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation