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Clinical relevance

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Clinical Nephrotoxins

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Abstract

Acute renal failure may follow an exposure to a number of nephrotoxins, depending on the dose of drug administered and also on a wide variety of predisposing factors.

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References

  1. Rasmussen HH, Ibels LS. Acute renal failure: multivariant analysis of causes and risk factors. Am J Med 1982; 73: 211–8.

    Article  PubMed  CAS  Google Scholar 

  2. Hou SH, Bushunsky DA, Wish BB, Cohen JJ, Harrington JT. Hospital-acquired renal insufficiency: a prospective study. Am J Med 1983; 74: 243–8.

    Article  PubMed  CAS  Google Scholar 

  3. Kleinknecht D, Landais P, Goldfarb B. Les insuffisances rénales aiguës associées à des médicaments ou à des produits de contraste iodés. Résultats d’une enquête coopérative multicentrique de la Société de Néphrologie. Néphrologie 1986; 7: 41–6.

    PubMed  CAS  Google Scholar 

  4. Kaufman J, Dhakal M, Patel B, Hamburger R. Community-acquired acute renal failure. Am J Kidney Dis 1991; 17: 191–8.

    PubMed  CAS  Google Scholar 

  5. Bennett WM, Porter GA. Overview of clinical nephrotoxicity. In: Hook JB, Goldstein RS, editors. Toxicology of the kidney. New York: Raven Press, 1993: 61–97.

    Google Scholar 

  6. Frankel MC, Weinstein AM, Stenzel KH. Prognostic patterns in acute renal failure: the New York Hospital, 1981–1982. Clin Exp Dialysis Apheresis 1983; 7: 145–7.

    CAS  Google Scholar 

  7. Beard K, Perera DR, Jick H. Drug induced parenchymal renal disease in outpatients. J Clin Pharmacol 1988; 28: 431–5.

    Article  PubMed  CAS  Google Scholar 

  8. Davidman M, Olsen P, Kohen J, Leither T, Kjellstrand C. Iatrogenic renal disease. Arch Intern Med 1991; 151: 1809–12.

    Article  PubMed  CAS  Google Scholar 

  9. Pru C, Ebben J, Kjellstrand C. Chronic renal failure after acute tubular necrosis. Kidney Int 1982; 21: 176.

    Google Scholar 

  10. Fleury D, Vanhille P, Pallot JL, Kleinknecht D. Drug induced acute renal failure: a preventable disease linked to drug misuse. Kidney Int 1990; 38: 1238.

    Google Scholar 

  11. Wing AJ, Broyer M, Brunner FP, Brynger H, Challah S, Donckerwolcke RA, Gretz N, Jacobs C, Kramer P, Seiwood NH. Combined report on regular dialysis and transplantation in Europe XIII. Acute (reversible) renal failure. Proc Eur Dial Transpl Assoc 1983; 20: 64–71.

    Google Scholar 

  12. Kleinknecht D. Diseases of the kidney caused by nonsteroidal anti-inflammatory drugs. In: Stewart JH, editor. Oxford: Oxford University Press, 1993: 160–73.

    Google Scholar 

  13. Bridoux F, Hazzan M, Pallot JL, Fleury D, Lemaitre V, Kleinknecht D, Vanhille Ph. Acute renal failure after the use of angiotensin-converting enzyme inhibitors in patients without renal artery stenosis. Nephrol Dial Transplant 1992; 7: 100–4.

    PubMed  CAS  Google Scholar 

  14. Kleinknecht D, Landais P, Goldfarb B. Pathophysiology and clinical aspects of drug-induced tubular necrosis in man. Contrib Nephrol 1987; 55: 145–58.

    PubMed  CAS  Google Scholar 

  15. Richet G, Sraer JD, Kourilsky O. La ponction-biopsie rénale dans l’insuffisance rénale aiguë. Ann Méd Interne 1978; 129: 335–7.

    Google Scholar 

  16. Linton AL, Clark W, Driedger AA, Turnbull DJ, Lindsay RM. Acute interstitial nephritis due to drugs. Review of the literature with a report of nine cases. Ann Intern Med 1980; 93: 735–41.

    Article  PubMed  CAS  Google Scholar 

  17. Buysen JGM, Houthoff HJ, Krediet RT, Arisz L. Acute interstitial nephritis: a clinical and morphological study in 27 patients. Nephrol Dial Transplant 1990; 5: 94–9.

    Article  PubMed  CAS  Google Scholar 

  18. Grunfeld JP, Kleinknecht D, Droz D. Acute interstitial nephritis. In: Schrier RW, Gottschalk CW, editors. Diseases of the Kidney. Boston: Little Brown, 1993: 1331–53.

    Google Scholar 

  19. Lieberthal W, Levinsky NG. Acute clinical renal failure. In: Seldin W, Giebisch G, editors. The kidney: physiology and pathophysiology. New York: Raven Press, 1992: 3181–225.

    Google Scholar 

  20. Henrich WL. Nephrotoxicity of nonsteroidal anti-inflammatory agents. In: Schrier RW, Gottschalk CW, editors. Diseases of the kidney. Boston: Little Brown, 1993: 1203–17.

    Google Scholar 

  21. Nicholls AJ, Shortland JR, Brown CB. Mefenamic acid nephropathy — a spectrum of renal lesions. Proc Eur Dial Transpl Assoc 1985; 22: 991–6.

    Google Scholar 

  22. Corwin HL, Bonventre JV. Renal insufficiency associated with nonsteroidal anti-inflammatory agents. Am J Kidney Dis 1984; 4: 147–52.

    PubMed  CAS  Google Scholar 

  23. Kleinknecht D, Landais P, Goldfarb B. Analgesic and nonsteroidal anti-inflammatory drug-associated acute renal failure: a prospective study. Clin Nephrol 1986; 25: 275–81.

    PubMed  CAS  Google Scholar 

  24. Makdassi R, Andrejak M, Westeel PF, Schmit JL, Renaud H, Houhou S, Fournier A. Aetiology and prognosis of iatrogenic renal failure on the basis of a 6-year experience. Nephrol Dial Transplant 1990; 5: 660–1.

    Google Scholar 

  25. Boiskin M, Marcussen N, Kjellstrand C. ACE inhibitors are now the second most common cause of acute, iatrogenic renal failure. J Am Soc Nephrol 1992; 3: 720.

    Google Scholar 

  26. Schusterman N, Strom BL, Murray TG, Morrison G, West SL, Maislin G. Risk factors and outcome of hospital-acquired acute renal failure. Am J Med 1987; 83: 65–71.

    Article  Google Scholar 

  27. Aviv A, John E, Bernstein J, Goldsmith DI, Spitzer A. Lead intoxication during development. Its late effects on renal function and blood pressure. Kidney Int 1980; 17: 430–43.

    Article  PubMed  CAS  Google Scholar 

  28. Parker RA, Bennett WM, Porter GA. Animal models in the study of aminoglycoside nephrotoxicity. In: Whelton A, Neu HC, editors. The aminoglycosides: microbiology, clinical use and toxicology. New York and Basel: Marcel Dekker Inc, 1982; 235–68.

    Google Scholar 

  29. Swann RC, Merrill JP. The clinical course of acute renal failure. Medicine 1953; 32: 215–92.

    Article  PubMed  CAS  Google Scholar 

  30. USRDS 1993 Annual Data Report. U.S. Renal Data System, NIH, NIDDK. 1993; Bethesda, MD.

    Google Scholar 

  31. Combined report on regular dialysis and transplantation in Europe, XIX, 1988. Nephrol Dial Transplant 1989; 4 (suppl 4): 5–29.

    Google Scholar 

  32. Porter GA, Bennett WM, Gilbert DN. Unraveling aminoglycoside nephrotoxicity using animal models. J Clin Pharmacol 1983; 23: 445–52.

    PubMed  CAS  Google Scholar 

  33. Steenland NK, Thun MJ, Ferguson CW, Port FK. Occupational and other exposures associated with male end-stage renal disease: a case/control study. Am J Pub Health 1990; 80: 153–9.

    Article  CAS  Google Scholar 

  34. Sandler DP, Smith JC. Chronic renal disease risk associated with employment in industries with potential solvent exposure. In: Bach PH, Gregg NJ, Wiks MF, Delacruz L, editors. Nephrotoxicity mechanisms, early diagnosis, and therapeutic management. New York, Basel, Hong Kong: Marcel Dekker Inc, 1991: 261–6.

    Google Scholar 

  35. Landrigan PJ, Goyer RA, Clarkson TW, Sandler DP, Smith JH, Thun MJ, Wedeen RP. The work-relatedness of renal disease. Arch Environ Health 1984; 39: 225–30.

    Article  PubMed  CAS  Google Scholar 

  36. Staessen J, Yeoman WB, Fletcher AE, Markowe HLJ, Marmot MG, Rose G, Semmence A, Shipley MJ, Bulpitt CJ. Blood lead concentration, renal function and blood pressure in London civil servants. Brit J Ind Med 1990; 47: 442–7.

    CAS  Google Scholar 

  37. Gregg NJ, Elseviers MM, De Broe ME, Bach PH. Epidemiology and mechanistic basis of analgesic nephropathy. Toxicol Lett 1989; 46: 141–51.

    Article  PubMed  CAS  Google Scholar 

  38. Sandler DP. Epidemiology in the assessment of nephrotoxicity. In: Bach PH, Lock EA, editors. Nephrotoxicity in the experimental and clinical situation. Dordrecht, Boston, Lancaster: Martinus Nijhoff, 1987: 847–83.

    Chapter  Google Scholar 

  39. Iesato K, Wakastin M, Wakastin Y. Renal tubular dysfunction in Minimata disease. Ann Intern Med 1977; 86: 731–3.

    Article  PubMed  CAS  Google Scholar 

  40. Staessen JA, Lauwerys RR, Buchet JP, Bulpitt CJ, Rondia D, Vanrenterghem Y, Amery A, Cadmibel Study Group. Impairment of renal function with increasing blood lead concentrations in the general population. N Engl J Med 1992; 327: 151–6.

    Article  PubMed  CAS  Google Scholar 

  41. Bennett WM, Elzinga LW, Porter GA. Tubulointerstitial disease and toxic nephropathy. In: Brenner BM, Rector FC Jr, editors. The kidney. Philadelphia, London, Toronto, Montreal, Sydney, Tokyo: WB Saunders, 1991: 1430–96.

    Google Scholar 

  42. Moore RD, Smith CR, Lipsky JJ, Mellitus ED, Lietman PS. Risk factors for nephrotoxicity in patients treated with aminoglycosides. Ann Intern Med 1984; 100: 352–73.

    Article  PubMed  CAS  Google Scholar 

  43. Porter GA. Risk factors for toxic nephropathies. Toxicol Lett 1989; 46: 269–79.

    Article  PubMed  CAS  Google Scholar 

  44. Cremer W, Bock KD. Symptoms and causes of chronic hypokalemic nephropathy in man. Clin Nephrol 1977; 7: 112–23.

    PubMed  CAS  Google Scholar 

  45. Wedeen RP. Poison in the pot: the legacy of lead. Carbondale: So Illinois Univ Press, 1984.

    Google Scholar 

  46. Mudge GH. Analgesic nephropathy: renal drug distribution and metabolism. In: Porter GA, editor. Nephrotoxic mechanisms of drugs and environmental toxins. New York, London: Plenum Med Bk Co, 1982: 209–25.

    Chapter  Google Scholar 

  47. Chester AC, Rakowski TI, Argy WP, Giacalone A, Schreiner GE. Hemodialysis in the eighth and ninth decade of life. Arch Intern Med 1979; 139: 1001–5.

    Article  PubMed  CAS  Google Scholar 

  48. Marcias-Nunez JE, Cameron JS. Renal function and disease in the elderly. London, Boston, Durban, Singapore, Sydney, Toronto, Wellington: Butterworth, 1987: 503.

    Google Scholar 

  49. Mudge GH. Nephrotoxicity of urographic radiocontrast drugs. Kidney Int 1980; 18: 540–52.

    Article  PubMed  CAS  Google Scholar 

  50. De Jong PE, Statius van Eps LW. Sickle cell nephropathy: new insights into its pathophysiology. Kidney Int 1985; 27: 711–9.

    Article  PubMed  CAS  Google Scholar 

  51. Allen M, Lawson L, Eckman JR, Delaney V, Bourke E. Effects of nonsteroidal anti-inflammatory drugs on renal function in sickle cell anemia. Kidney Int 1988; 34: 500–6.

    Article  Google Scholar 

  52. Porter GA. Contrast associated nephropathy. Am J Cardiol 1989; 64: 22E–6E.

    Article  Google Scholar 

  53. Rao TK, Nicastri AD, Friedman EA. Natural history of heroin-associated nephropathy. N Engl J Med 1974; 290: 19–25.

    Article  PubMed  CAS  Google Scholar 

  54. Dubrow A, Mittman N, Ghali V, Flamenbaum W. The changing spectrum of heroin associated nephropathy. Am J Kidney Dis 1985; 5: 36–43.

    PubMed  CAS  Google Scholar 

  55. Cunningham EE, Zielezny MA, Venuto RC. Heroinassociated nephropathy — a nationwide problem. JAMA 1983; 250: 2935–8.

    Article  PubMed  CAS  Google Scholar 

  56. Warner E. Cocaine abuse. Ann Intern Med 1993; 119: 226–35.

    Article  PubMed  CAS  Google Scholar 

  57. Citron BP, Halpern M, McCarron M, Lundberg GD, McCormick R, Pincus IJ, Tatter D, Haverback BJ. Necrotizing angitis associated with drug abuse. N Engl J Med 1970; 283: 1003–7.

    Article  PubMed  CAS  Google Scholar 

  58. Porter GA. Antimicrobial nephrotoxicity. In: Massry SG, Glassock JR, editors. Textbook of nephrology. Baltimore, MD: Williams & Wilkins, 1989: 812–8.

    Google Scholar 

  59. Swartz RD, Rubin JE, Leeming BW, Silva P. Renal failure following major angiography. Am J Med 1978; 65: 31–7.

    Article  PubMed  CAS  Google Scholar 

  60. Cochran ST, Wong WS, Roe DJ. Predicting angiog-raphic-induced acute renal impairment: clinical risk model. Am J Radiol 1983; 141: 1027–33.

    CAS  Google Scholar 

  61. Cigarroa RG, Lange RA, Williams RH, Hillis LD. Dosing of contrast material to prevent contrast nephropathy in patients with renal disease. Am J Med 1989; 86: 649–52.

    Article  PubMed  CAS  Google Scholar 

  62. Leehey DJ, Braun DA, Tholl LS, Chung CA, Gross JA, Lentino JR. Can pharmacokinetic dosing decrease nephrotoxicity associated with aminoglycoside therapy? J Am Soc Nephrol 1993; 4: 81–90.

    PubMed  CAS  Google Scholar 

  63. Swann SK, Bennett WM. Nephrotoxic acute renal failure. In: Lazarus JM, Brenner BM, editors. Acute renal failure. New York: Churchill Livingston, 1993: 357–92.

    Google Scholar 

  64. Levenson DJ, Simmons CE, Brenner BM. Arachidonic acid metabolism, prostaglandins and the kidney. Am J Med 1982; 72: 354–74.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Dieter Kleinknecht
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  2. George A. Porter
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Editor information

Editors and Affiliations

  1. Division of Nephrology and Hypertension, University of Antwerp, Belgium

    M. E. De Broe  & G. A. Verpooten  & 

  2. Department of Medicine, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    G. A. Porter

  3. Division of Nephrology, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    W. M. Bennett

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© 1998 Springer Science+Business Media Dordrecht

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Kleinknecht, D., Porter, G.A. (1998). Clinical relevance. In: De Broe, M.E., Porter, G.A., Bennett, W.M., Verpooten, G.A. (eds) Clinical Nephrotoxins. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9088-4_1

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  • DOI: https://doi.org/10.1007/978-94-015-9088-4_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-015-9090-7

  • Online ISBN: 978-94-015-9088-4

  • eBook Packages: Springer Book Archive

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