Developmental Era The 1990s and beyond

  • Catherine A. Neill
  • Edward B. Clark
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 163)


Observations of the developing cardiovascular system date from antiquity. Aristotle pictured the beating heart in a chicken egg [303]. Leonardo DaVinci’s drawings of the developing embryo foreshadowed the accurate description of the shape changes that accompany the development of an embryo to fetus to living animal [304].


Human Embryo Bicuspid Aortic Valve Cardiac Development DiGeorge Syndrome Alagille Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Additional References

  1. 302.
    Sabin FR. Franklin Paine Mall, the Story of a Mind. Baltimore: Johns Hopkins Press, 1934.Google Scholar
  2. 303.
    Adelmann, HB. Marcello Malpighi and the evolution of embryology. Ithaca NY: Cornell Univ Press 1966; vol 2:729–781, vol 3: 1300–1511.Google Scholar
  3. 304.
    O’Malley CD, Saunders JBdeCM. Leonardo da Vinci on the human body. New York: Henry Schuman, 1952.Google Scholar
  4. 305.
    O’Rahilly R. One hundred years of human embryology. Issues Rev. Teratol. 1988; 4: 8 1128.Google Scholar
  5. 306.
    Mall FP. A plea for an institute of human embryology. JAMA 1913; 60: 1599–1601.CrossRefGoogle Scholar
  6. 307.
    O’Rahilly R, Muller E Developmental stages in human embryos. Baltimore: Carnegie Institution of Washington, Publication 637, 1987.Google Scholar
  7. 308.
    Jaffee, OC. Cardiac development with special reference to congenital heart disease. Dayton, Ohio: University of Dayton Press, 1970.Google Scholar
  8. 309.
    Rosenquist GC, Bergsma D. Morphogenesis and malformation of the cardiovascular system. New York, Alan R. Liss, National Foundation-March of Dimes. Birth Defects: Original Article Series, Vol XIV, No. 7, 1978.Google Scholar
  9. 310.
    Pexieder T. Mechanisms of cardiac morphogenesis and teratogenesis. New York, Raven Press, 1981.Google Scholar
  10. 311.
    VanPraagh R, Takao A. Etiology and morphogenesis of congenital heart disease. Mount Kisco, NY: Futura, 1980.Google Scholar
  11. 312.
    Nora JJ, Takao A. Congenital heart disease: Causes and progress. Mount Kisco, NY: Futura Publishing, 1985.Google Scholar
  12. 313.
    Clark EB, Takao A. Developmental cardiology: Morphogenesis and function. Mount Kisco, NY: Futura Publishing, 1990.Google Scholar
  13. 314.
    Clark EB, Markwald RR, Takao A. Developmental mechanisms of heart disease. Mount Kisco, NY: Futura Publishing, 1994.Google Scholar
  14. 315.
    Anderson RH. Terminology. In: Anderson RH, Macartney FJ, Shinebourne EA, Tynan M, eds. Paediatric Cardiology. Edinburgh: Churchill Livingstone 1987: 65–82.Google Scholar
  15. 316.
    Clark EB. Epidemiology of congenital cardiovascular malformations. In: Emmanouilides GC, Riemenschneider TA, Allen H,Gutgesell HP eds. Heart Disease in Infants, Children and Adolescents, 5th Edition. Baltimore: Williams and Wilkins, 1994.Google Scholar
  16. 317.
    Moller JH. Fifty years of pediatric cardiology and challenges for the future. Circulation 1994; 89: 2479–2483.PubMedCrossRefGoogle Scholar
  17. 318.
    Takao A, Momma K, Kondoh C, Ando M, Shimizu T, Burn J, Matsuoka R. Conotruncal anomaly face syndrome. In: Clark EB, Markwald RR, Takao A eds. Developmental mechanisms of heart disease. Mt. Kisco NY: Futura Publishing 1994.Google Scholar
  18. 319.
    Lammer EJ, Opitz JM. The DiGeorge anomaly as a developmental field defect. Am J Med Genet 1986; 2 (suppl): 113–127.CrossRefGoogle Scholar
  19. 320.
    Burn J. Human models of cardiac defects. In: Clark EB, Markwald RR, Takao A eds. Developmental mechanisms of heart disease. Mt. Kisco NY: Futura Publishing 1994.Google Scholar
  20. 321.
    Ferrans VJ, Rosenquist G, Weinstein C. Cardiac morphogenesis. New York: Elsevier, 1985.Google Scholar
  21. 322.
    Moller JH, Allen HD, Clark EB, Dajani AS, Golden A, Hayman LL, Lauer RM, Marmer EL, McAnulty JH, Oparil S, Strauss AW, Taubert KA, Wagner A. Report of the Task Force on Children and Youth. Circulation 1993; 88: 2479–2486.PubMedCrossRefGoogle Scholar
  22. 323.
    Patterson DF, Pexieder T, Schnarr WR, Navratil T, Alaili R. A single major gene defect underlying cardiac conotruncal malformations interferes with myocardial growth during embryonic development: studies in the CTD line of keeshond dogs. Am J Hum Genet 1993; 52: 388–397.PubMedGoogle Scholar
  23. 324.
    Hansen JT, Sadek JR. Fetal research. Science 1989; 246: 775–779.Google Scholar
  24. 325.
    Taussig HB. Evolutionary origin of cardiac malformations. JACC 1988; 12: 1079–1086.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1995

Authors and Affiliations

  • Catherine A. Neill
    • 1
  • Edward B. Clark
    • 2
  1. 1.Johns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Rochester School of MedicineRochesterUSA

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