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Restenosis assessed by quantitative angiography. Lessons learned from two european multicenter trials

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Quantitative Coronary Angiography in Clinical Practice

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 145))

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Abstract

Over the past years several large randomized restenosis prevention trials have been carried out in Europe [1, 2]. These well organized and meticulously executed trials yielded an enormous amount of high quality clinical and quantitative angiographic data. This allowed us to perform additional analyses with the purpose of gaining more insight in the enigmatic restenosis process, which is still surrounded by conclusions drawn from retrospective trials with non-standardized angiography protocols, incomplete angiographic follow-up and qualitative analysis of the angiograms. In this chapter the spinoff of the Carport and Mercator trials will be described. The Carport and Mercator trials were the first multicenter European restenosis prevention trials with a standardized angiography protocol and an almost complete quantitative angiographic follow up. In both trials quantitative angiographic and clinical outcome were similar in both the active treatment group and the placebo group, so for the secondary analyses both groups could be pooled. The results of these trials will be discussed in chapter 26. The extensive experience with restenosis and quantitative angiography [3] at the Thoraxcenter allowed us to develop a standardized protocol for the acquisition of the angiographic data which was easily implemented in the day to day practice of 32 catheterization laboratories in Europe. Furthermore the analysis of both baseline and follow-up coronary angiogram was done in a central core laboratory with strict guidelines for the analysts.

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Authors
  1. Benno J. Rensing
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  2. Walter R. M. Hermans
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  3. Patrick W. Serruys
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Editors and Affiliations

  1. Thoraxcenter, Erasmus, University Rotterdam, Rotterdam, The Netherlands

    Patrick W. Serruys , David P. Foley  & Pim J. De Feyter ,  & 

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Rensing, B.J., Hermans, W.R.M., Serruys, P.W. (1994). Restenosis assessed by quantitative angiography. Lessons learned from two european multicenter trials. In: Serruys, P.W., Foley, D.P., De Feyter, P.J. (eds) Quantitative Coronary Angiography in Clinical Practice. Developments in Cardiovascular Medicine, vol 145. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-8358-9_28

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  • DOI: https://doi.org/10.1007/978-94-015-8358-9_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-4295-8

  • Online ISBN: 978-94-015-8358-9

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