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Functional Mapping of the Human Brain

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Developmental Neurocognition: Speech and Face Processing in the First Year of Life

Part of the book series: NATO ASI Series ((ASID,volume 69))

Abstract

A review of current and potential imaging techniques that can be used to map human brain activity is presented. The most advanced method, i.e. positron emission tomography (PET) and repeated cerebral blood flow (CBF) imaging with oxygen-15 labelled water is then further detailed, including recent advances and current unsolved questions in the acquisition and analysis of such data. The major results obtained using this technique in adults in the field of speech and face processing are then discussed. Finally, the feasibility of applying some of these imaging techniques to the study of cognitive functions in infancy is discussed.

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References

  • Belliveau, J.W., Kennedy, D.N., McKinstry, R.C., Buchbinder, B.R., Weiskoff, R.M., Cohen, M.S., Veavea, J.M., Brady, T.J., Rosen, B.R. (1991) ‘Functional mapping of the human visual cortex by magnetic resonance imaging’, Science 254, 716–719.

    Article  Google Scholar 

  • Budinger, T.F. (1980) ‘Physical attributes of single-photon tomography’, J. Nucl. Med. 21, 579–592.

    Google Scholar 

  • Chariot, V., Tzourio, N., Zilbovicius, M., Mazoyer, B.M., Denis, M. (1992) ‘Different mental imagery abilities result in different regional cerebral blood flow activation patterns during cognitive tasks’, Neuropsychologia 30–6, 565–580.

    Article  Google Scholar 

  • Christophe, C., Muller, M.F., Baleriaux, D., Kahn, A., Pardou, A., Perlmutter, N., Szliwowski, H., Segebarth, C. (1990) ‘Mapping of normal brain maturation in infants on phase-sensitive inversion-recovery MR images’, Neuroradiol. 32, 173–178.

    Article  Google Scholar 

  • Chugani, H.T. (1992) ‘Functional Brain Imaging in Pediatrics’, Pediatr. Neurol. 39, 777–799.

    Google Scholar 

  • Chugani, H.T., Phelps, M.E. (1986) ‘Maturational changes in cerebral functions in infants determined by 18FDG positron emission tomography’, Science 231, 840–843.

    Article  Google Scholar 

  • Chugani, H.T., Phelps, M.E., Mazziotta, J.C. (1987) ‘Positron emission tomography study of human brain functional development’, Ann. Neurol. 22, 487–497.

    Article  Google Scholar 

  • Corbetta, M., Miezin, F., Dobmeyer, S., Shulman, G.L., Petersen, S.E. (1990) ‘Attentional modulation of neural processing of shape, color, and velocity in humans’, Science 248, 1556–1559.

    Article  Google Scholar 

  • Corbetta, M., Miezin, F.M., Dobmeyer, S., Shulman, G.L., Petersen, S.E. (1991) ‘Selective and Divided Attention during Visual Discriminations of Shape, Color, and Speed: Functional Anatomy by Positron Emission Tomography’, J. Neurosci. 11/8, 2383–2402.

    Google Scholar 

  • Cormack, A.M. (1963) ‘Representation of a function by its line integrals with some radiological applications’, J. Appl. Phys. 34, 2722–2727.

    Article  Google Scholar 

  • Crease, R.P. (1991) ‘Images of conflict: MEG vs. EEG’, Science 253, 374–375.

    Article  Google Scholar 

  • Drevets, W.C., Videen, T.O., Macleod, A.K., Haller, J.W., Raichle, M.E. (1992) ‘Pet Images of Blood Flow Changes During Anxiety — Correction’, Science 256–5064, 1696.

    Google Scholar 

  • Emery, J.R., Peabody, J.L., Ashwal, S., Assaas, A., Brown, W., Thompson, J. (1992) ‘ Modification of Xenon-Enhanced Computed Tomography for Assessing Regional Cerebral Blood Flow in Newborns’, in Howard Yonas, (ed.), Cerebral Blood Flow Measurement with Stable Xenon-Enhanced Computed Tomography, Raven Press, New York, pp. 46–49.

    Google Scholar 

  • Evans, A.C., Beil, C., Marrett, S., Thompson, C.J., Hakim, A. (1988) ‘Anatomical-functional correlation using an adjustable MRI-based region of interest atlas with positron emission tomography’, J. Cereb. Blood Flow Metab. 8, 513–530.

    Article  Google Scholar 

  • Evans, A.C., Marrett, S., Neehn, P., Collins, L., Worsley, K., Dai, W., Milot, S., Meyer, E., Bub, D. (1992) ‘Anatomical Mapping of Fuinctional Activation in Stereotactic Coordinate Space’, Neuroimage 1, 43–53.

    Article  Google Scholar 

  • Fox, P.T. (1989) ‘Functional Brain Mapping with Positron Emission Tomography’, Semin. Neurol. 9/4, 323–329.

    Article  Google Scholar 

  • Fox, P.T., Mintun, M.A., Raichle, M.E., Miezin, F.M., Allman, J.L., Van Essen, D.C. (1986) ‘Mapping human visual cortex with positron emission tomography’, Nature 323, 806–809.

    Article  Google Scholar 

  • Fox, P.T., Mintun, M.A., Reiman, E.M., Raichle, M.E. (1988) ‘Enhanced detection of focal brain response using intersubject averaging and change-distribution analysis of substracted PET images’, J. Cereb. Blood Flow Metab. 8, 642–653.

    Article  Google Scholar 

  • Fox, P.T., Perlmutter, J.S.A., Raichle, M.E. (1985) ‘A stereotactic method of anatomical localization for positron emission tomography’, J. Comput. Assist. Tomogr. 9, 141–153.

    Article  Google Scholar 

  • Fox, P.T., Raichle, M.E. (1984) ‘Stimulus rate dependence of regional cerebral blood flow in human striate cortex demonstrated by Positron Emission Tomography’, J. Neurophysiol. 51, 1109–1120.

    Google Scholar 

  • Fox, P.T., Raichle, M.E., Tach, W.T. (1985) ‘Functional mapping of the human cerebellum with positron emission tomography’, Proc. Nat. Acad. Sci. USA 82, 7462–7466.

    Article  Google Scholar 

  • Friston, K.J., Frith, C.D., Liddle, P.F., Dolan, R.J., Lammertsma, A.A., Frackowiak, R.S.J. (1990) ‘The relationship between global and local changes in PET scans’, J. Cereb. Blood Flow Metab. 10, 458–466.

    Article  Google Scholar 

  • Friston, K.J., Frith, C.D., Liddle, P.F., Frackowiak, R.SJ. (1991) ‘Comparing functional (PET) images: the assessment of significant changes’, J. Cereb. Blood Flow Metab. 11, 690–699.

    Article  Google Scholar 

  • Frith, C.D., Friston, K.J., Liddle, P.F., Frackowiak, R.SJ. (1991) ‘A PET study of word finding’, Neuropsychologia 29, 1137–1148.

    Article  Google Scholar 

  • Galaburda, A.M., Rosen, G.D., Sherman, G.F. (1990) ‘Individual variability in cortical organization: its relationship to brain laterality and implications to function’, Neuropsychologia 28, 529–546.

    Article  Google Scholar 

  • Geschwind, N., Levitsky, W. (1968) ‘Human brain: Left-Righ Asymmetries in Temporal Speech Region’, Science 161, 186–187.

    Article  Google Scholar 

  • Gevins, A.S., Morgan, N.H., Bressler, S.L., Cutillo, B.A., White, R.M., Illes, J., Greer, D.S., Doyle, J.C., Zeitlin, G.M. (1987) ‘Human neuroelectric patterns predict performance accuracy’, Science 235, 580–585.

    Article  Google Scholar 

  • Gobbel, G.T., Cann, C.E., Fike, J.R. (1991) ‘Measurement of regional cerebral blood flow using ultrafast computed tomography’, Stroke 22, 768–771.

    Article  Google Scholar 

  • Grafton, S.T., Woods, R.P., Mazziotta, J.C., Phelps, M.E. (1991) ‘Somatotopic mapping of the primary motor cortex in humans: activation studies with cerebral blood flow and positron emission tomography’, J. Neurophysiol. 66, 735–743.

    Google Scholar 

  • Hari, R., Lunasmaa, O.V. (1989) ‘Recording and interpretation of cerebral magnetic fields’, Science 244, 432–436.

    Article  Google Scholar 

  • Haxby, J.V., Grady, C.L., Horwitz, B., Ungerleider, L.G., Mishkin, M., Carson, R.E., Herscovitch, P., Schapiro, M.B., Rapoport, S. (1991) ‘Dissociation of object and spatial visual processing pathways in human extrastriate cortex’, Proc. Natl. Acad. Sci. USA 88, 1621–1625.

    Article  Google Scholar 

  • Herscovitch, P., Markham, J., Raichle, M.E. (1983) ‘Brain blood flow measured with intravenous H215Ö. I. Theory and error analysis’, J. Nucl. Med. 24, 782–789.

    Google Scholar 

  • Holder, D.S. (1987) ‘Feasibility of developing a method of imaging neuronal activity in the human brain: a theoretical review’, Med. Biol. Eng. Comput. 25, 2–11.

    Article  Google Scholar 

  • Hounsfield, G.N. (1973) ‘Computerized transverse axial scanning tomography: Part I Description of the system’, Br. J. Radiol. 46, 1016–1022.

    Article  Google Scholar 

  • Joliot, M., Mazoyer, B.M. (1991) ‘3-D segmentation, interpolation and delineation of cortical gyri on MRI data’, IEEE Med. Imag. Conf. Rec.

    Google Scholar 

  • Kanno, I., Iida, H., Miura, S. (1991) ‘Optimal scan time of Oxygen-15-labeled water injection method for measurement of cerebral blood flow’, J. Nucl. Med. 32 1931–1934.

    Google Scholar 

  • Kwong, K.K., Belliveau, J.W., Chesler, D.A., Goldberg, I.E., Weisskoff, R.M., Poncelet, B.P., Kennedy, D.N., Hoppel, B.E., Cohen, M.S., Turner, R., Cheng, H.M., Brady, T.J., Rosen, B.R. (1992) ‘Dynamic Magnetic Resonance Imaging of Human Brain Activity During Primary Sensory Stimulation’, Proc. Natl. Acad. Sci. USA 89–12, 5675–5679.

    Article  Google Scholar 

  • Lauterbur, P.C. (1973) ‘Image formation by induced local interactions: examples employing nuclear magnetic resonance’, Nature 242, 190–191.

    Article  Google Scholar 

  • Lueck, C.J., Zeki, S., Friston, K.J., Deiber, M.P., Cope, P., Cunningham, V.J., Lammertsma, A.A., Kennard, C., Frackowiak, R.S.J. (1989) ‘The colour center in the cerebral cortex of man’, Nature 340, 386–389.

    Article  Google Scholar 

  • Martin, E., Boesch, C., Zuerrer, M., Kikinis, R., Molinari, L., Kaelin, P., Bolthauser, E., Duc, G. (1990) ‘MR imaging of brain maturation in normal and developmentally handicapped children’, J. Comput. Assist. Tomogr. 14, 685–692.

    Article  Google Scholar 

  • Mazoyer, B., Dehaene, S., Tzourio, N., Murayama, N., Cohen, L., Lxévrier, O., Salamon, G., Syrota, A, Mehler, J. (1992) ‘Regional cerebral blood flow changes during story listening’, Soc. Neurosci. Abstr. 18, 933.(Abstr.)

    Google Scholar 

  • Mazoyer, B.M., Trebossen, R., Deutsch, R., Casey, M., Blohm, K. (1991) ‘Physical Characteristics of a New High Spatial Resolution Brain Positron Tomograph’, IEEE Trans. Med. Imag. 10–4, 499–504.

    Article  Google Scholar 

  • Mora, B.N., Carman, G.J., Allman, J.M. (1989) ‘In vivo functional localization of the human visual cortex using positron emission tomography and magnetic resonance imaging’, TINS 12, 282–284.

    Google Scholar 

  • Ogawa, S., Tank, D.W., Menon, R., Eilermann, J.M., Kim, S.G., Merkle, H., Ugurbil, K. (1992) ‘Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging’, Proc. Nat. Acad. Sci. USA 89, 5951–5955.

    Article  Google Scholar 

  • Ono, M., Kubik, S., Abernathey, C.D. (1990) Atlas of Cerebral Sulci, Georg Thieme Verlag, Stuttgart.

    Google Scholar 

  • Pelizzari, C.A., Chen, G.T.Y., Speibring, D.R., Weichselbaum, R.R., Chen, CT. (1989) ‘Accurate three-dimensional registration of CT, PET and/or MRI images of the brain’, J. Comput. Assist. Tomogr. 13, 20–26.

    Article  Google Scholar 

  • Penn, R.D., Trinko, B., Baldwin, L. (1980) ‘Brain maturation followed by computed tomography’, J. Comput. Assist. Tomogr. 4, 614–616.

    Article  Google Scholar 

  • Petersen, S.E., Fox, P.T., Posner, M.I., Mintun, M.A., Raichle, M.E. (1988) ‘Positron emission tomographic studies of the cortical anatomy of single-word processing’, Nature 331, 585–589.

    Article  Google Scholar 

  • Petersen, S.E., Fox, P.T., Snyder, A.Z., Raichle, M.E. (1990) ‘Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli’, Science 249, 1041–1044.

    Article  Google Scholar 

  • Phelps, M.E. (1991) ‘PET: a biological imaging technique’, Neurochem. Res. 16, 929–940.

    Article  Google Scholar 

  • Phelps, M.E., Huang, S.C., Hoffman, E.J., Selin, C., Sokoloff, L., Kuhl, D.E. (1979) ‘Tomographic measurement of local cerebral glucose metabolic rate with (F-18)2-fluoro-2-deoxy-D-glucose: validation of the method’, Ann. Neurol. 6, 371–388.

    Article  Google Scholar 

  • Pietrzyk, U., Herholz, K., Heiss, W.D. (1990) ‘Three-dimensional alignment of functional and morphological tomograms’, J. Comput. Assist. Tomogr. 14, 51–59.

    Article  Google Scholar 

  • Poline, J.B., Mazoyer, B.M. (1991) ‘Towards an individual analysis of brain activation PET studies: optimal filtering of difference images’, J. Cereb. Blood Flow Metab. 11, S564.

    Google Scholar 

  • Posner, M.L., Petersen, S.E., Fox, P.T., Raichle, M.E. (1988) ‘Localization of Cognitive Operations in the Human brain’, Science 240, 1627–1631.

    Article  Google Scholar 

  • Raichle, M.E., Martin, W.R.W., Herscovitch, P., Mintun, M.A., Markham, J. (1984) ‘Brain blood flow measured with intravenous H2150. II. Implementation and validation’, J. Nucl. Med. 24, 790–798.

    Google Scholar 

  • Ribary, U., Ioannides, A.A., Singh, K.D., Hasson, R., Bolton, J.P.R., Lado, F., Mogilner, A., Llinas, R. (1991) ‘Magnetic field tomography (MFT) of coherent thalamo-cortical 40 Hz oscillations in humans’, Proc. Nat. Acad. Sci. USA 88, 11037–11041.

    Article  Google Scholar 

  • Rubinstein, M., Denays, R., Ham, H.R., Piepsz, A., VanPachterbeke, T., Haumont, D., Noel, P. (1989) ‘Functional imaging of brain maturation in humans using iodine-123 iodoamphetamine and SPECF, J. Nucl. Med. 30, 1982–1985.

    Google Scholar 

  • Sergent, J., Ohta, S., Macdonald, B. (1992) ‘Functional neuroanatomy of face and object processing’, Brain 115, 15–36.

    Article  Google Scholar 

  • Squire, L.R., Ojemann, J.G., Miezin, F.M., Petersen, S.E., Videen, T.O., Raichle, M.E. (1992) ‘Activation of the hippocampus in normal humans: A functional anatomical study of memory’, Proc. Nat. Acad. Sci. USA 89, 1837–1841.

    Article  Google Scholar 

  • Stehling, M.K., Turner, R., Mansfield, P. (1991) ‘Echo-planar imaging: magnetic resonance imaging in a fraction of a second’, Science 254, 43–50.

    Article  Google Scholar 

  • Steinmetz, H., Volkmann, J., Jäncke, L., Freund, HJ (1991) ‘Anatomical Left-Right Asymmetry of Language-related Temporal Cortex Is Different in Left-and Right-Handers’, Ann. Neurol. 29, 315–319.

    Article  Google Scholar 

  • Talairach, J., Tournoux, J. (1988) Co-planar Stereotaxic Atlas of the Human Brain, Georg Thieme Verlag, Stuttgart.

    Google Scholar 

  • Tzourio, N., Chiron, G, Raynaud, G, Dulac, O., Mazoyer, B.M., Bourguignon, M., Syrota, A. (1989) ‘Cerebral Maturation During the First 20 Months of Life Studied with the Regional Cerebral Blood Flow Measurements Using SPECT, in H.A.E. Schmidtand, G.L. Buraggi, (eds.), Trends and Possibility in Nuclear Medicine, Schattauer, Stuttgart, pp. 499–502.

    Google Scholar 

  • Tzourio, N., de Schonen, S., Mazoyer, B., Boré, A., Pietrzyk, U., Aujard, Y., Deruelle, G (1992) ‘Regional cerebral blood flow during visual stimuli processing in two-montn-old alert infants’, Soc. Neurosci. Abstr. 18, 1121.(Abstr.)

    Google Scholar 

  • VanderKnaap, M.S., Valk, J. (1990) ‘MR imaging of the various stages of normal myelination during the first year of life’, Neuroradiol. 31, 459–470.

    Article  Google Scholar 

  • Volkow, N.D., Mullani, N., Gould, L.K., Adler, S.A., Gatley, S.J. (1991) ‘Sensitivity measurements of regional brain activation with oxygen-15-water and PET to time of stimulation and period of image reconstruction’, J. Nucl. Med. 32, 58–61.

    Google Scholar 

  • Williams, D.S., Detre, J.A., Leigh, J.S., Koretsky, A.P. (1992) ‘Magnetic resonance imaging of perfusion using spin inversion of arterial water’, Proc. Nat. Acad. Sci. USA 89, 212–216.

    Article  Google Scholar 

  • Williamson, S.J., Kaufman, L. (1981) ‘Biomagnetism’, J. Magn. Magn. Mater. 22, 129–201.

    Article  Google Scholar 

  • Wise, R., Chollet, F., Hadar, U., Friston, K.J., Hoffner, E., Frackowiak, R.S.J. (1991) ‘Distribution of cortical networks involved in word comprehension and word retrieval’, Brain 114, 1803–1817.

    Article  Google Scholar 

  • Zatorre, R.J., Evans, A.C., Meyer, E., Gjedde, A. (1992) ‘Lateralization of Phonetic and Pitch Discrimination in Speech Processing’, Science 256, 846–849.

    Article  Google Scholar 

  • Zeki, S., Watson, J.D.G., Lueck, C.J., Friston, K.J., Kennard, G, Frackowiak, R.S.J. (1991) ‘A Direct Demonstration of Functional Specialization in Human Visual Cortex’, J. Neurosci. 11(3), 641–649.

    Google Scholar 

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Authors and Affiliations

  1. Groupe d’Imagerie Neurofonctionnelle, Service Hospitalier Frédéric Joliot, DRIPP-CEA, 91406, Orsay Cedex, France

    B. M. Mazoyer & N. Tzourio

  2. Hôpital Robert Debré, CHU Bichat, 48 Boulevard Sérurier, 75935, Paris Cedex 19, France

    B. M. Mazoyer & N. Tzourio

Authors
  1. B. M. Mazoyer
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  2. N. Tzourio
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Editor information

Editors and Affiliations

  1. Experimental Psychology Laboratory, E.H.E.S.S. and C.N.R.S., Paris, France

    Bénédicte de Boysson-Bardies

  2. Development and Cognition Unit, Cognitive Neuroscience Laboratory, C.N.R.S., Marseille, France

    Scania de Schonen

  3. Psychology Department, SUNY at Buffalo, Buffalo, New York, USA

    Peter Jusczyk

  4. Department of Linguistics, University of Texas, Austin, Texas, USA

    Peter McNeilage

  5. Cognitive Development Unit, MRC, London, UK

    John Morton

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Mazoyer, B.M., Tzourio, N. (1993). Functional Mapping of the Human Brain. In: de Boysson-Bardies, B., de Schonen, S., Jusczyk, P., McNeilage, P., Morton, J. (eds) Developmental Neurocognition: Speech and Face Processing in the First Year of Life. NATO ASI Series, vol 69. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-8234-6_7

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  • DOI: https://doi.org/10.1007/978-94-015-8234-6_7

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