Abstract
We have investigated some aspects of the interface between metallic biomedical implants and living tissue. To characterize this interface we have developed an STM coupled with a high resolution reflective optical microscope. The STM is used in connection with other microscopic techniques: TEM, SEM, and Auger spectroscopy. Initial biological measurements show that fibronectin (Fn), a glycoprotein which plays an important role in cell attachment and bacterial promotion, is attached on Ti and V substrates, but is not biologically active on V, a non-biocompatible substance. We present STM images of the Ti oxide layer and of single and multiple Fn molecules shadowed with a conductive layer.
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Emch, R., Clivaz, X., Taylor-Denes, C., Vaudaux, P., Lew, D., Descouts, P. (1990). Study of the Biocompatibility of Surgical Implant Materials at the Atomic and Molecular Level Using Scanning Tunneling Microscopy. In: Behm, R.J., Garcia, N., Rohrer, H. (eds) Scanning Tunneling Microscopy and Related Methods. NATO ASI Series, vol 184. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-7871-4_18
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DOI: https://doi.org/10.1007/978-94-015-7871-4_18
Publisher Name: Springer, Dordrecht
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